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Dive into the research topics where Miguel Ángel Crovetto is active.

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Featured researches published by Miguel Ángel Crovetto.


European Journal of Radiology | 2010

Anatomo-radiological study of the Superior Semicircular Canal Dehiscence Radiological considerations of Superior and Posterior Semicircular Canals.

Miguel Ángel Crovetto; Jaime Whyte; O.M. Rodriguez; I. Lecumberri; C. Martinez; J. Eléxpuru

INTRODUCTION The main purpose of this study is to determine the radiological incidence of Superior (SSCD) and Posterior Semicircular Canal Dehiscence (PSCD) and to compare radiologic SSCD to the incidence of this condition on cadaver specimen. We have also analysed the relation between the ossification state of the semicircular canals and the degree of mastoid pneumatization and integrity of Tegmen Tympani. MATERIAL AND METHODS Temporal bones have been investigated by means of CT scan on patients and direct observation on cadaver specimen, respectively. RESULTS 604 ears and 160 cadaver temporal bones have been investigated by means of CT scan and direct observation, respectively. 3.6% and 0.3% of the studied ears had SSCD and PSCD, respectively, on CT scan. Only 0.6% of the cadaver specimen ears did have anatomical SSCD. Degree of pneumatization of the mastoid bone is related to the mean thickness of bone overlying the Superior and Posterior Semicircular Canal. Radiological absence of Tegmen Tympani is more frequent in ears that also have radiologic SSCD. CONCLUSION CT scanning gives higher incidence figures of SSCD than anatomical studies, 3.6% vs. 0.6%. We also found a 0.6% incidence of radiological PSCD in the studied ears. There is a direct relation between the degree of ossification of Superior and Posterior Semicircular Canal and certain temporal bone anatomic features: temporal bone pneumatization and absence/presence of Tegmen Tympani or Antri.


Otology & Neurotology | 2012

Influence of aging and menopause in the origin of the superior semicircular canal dehiscence.

Miguel Ángel Crovetto; Jaime Whyte; Olívia Rodriguez; Iñigo Lecumberri; Claudio Martínez; Carmen Fernandez; Rafael Crovetto; Antonio Municio; Kalliopi Vrotsou

Objective Determine if aging and menopause, known to be associated with bone resortion, also are associated with superior semicircular canal dehiscence. Design Observational study. Setting Study conducted in 3 tertiary Spanish hospitals. Patients Nonselected consecutive patients of all ages. Interventions Thin-section multi-detector row computed tomographic scan of the temporal bones. Main Outcome Measure The minimum thickness of the bone covering the roof of the superior semicircular canal (SSC) measured in each temporal bone. The outcome was studied both as a continuous and as a dichotomous variable: thin (<0.6 mm) and normal (≥0.6 mm). Results Five hundred eighty-two ears of 312 patients were included in the study. Fifty-five percent of the sample were women. Patient’s age ranged from 2 to 88 years. A 40-year age difference between ears was associated with a decreased thickness of bone covering the SSC of 0.10 mm, which is 10% of the average thickness of such bone. The thickness of the bone overlying the SSC of subjects younger than 45 years was an average of 1.14 mm (SD, 0.52 mm), whereas that of the subjects older than 45 years was equal to 1.02 mm (SD, 0.45 mm; p = 0.006). The percentage of ears with thin bone coverage of SSC was 7.1% in subjects younger than 45 years and 13.8% in those older than 45 years (p = 0.013). Conclusion Our data support the hypothesis that there is a slight osteopenia of the roof of the superior semicircular canal associated with aging, and this effect seems to be more pronounced in menopausal women.


American Journal of Medical Genetics Part A | 2012

Absence of COCH gene mutations in patients with superior semicircular canal dehiscence

Miguel Ángel Crovetto; Jaime Whyte; Esther Sarasola; Jose Antonio Rodriguez; María J. García-Barcina

Absence of COCH Gene Mutations in Patients With Superior Semicircular Canal Dehiscence Miguel A. Crovetto, JaimeWhyte, Esther Sarasola, Jose A. Rodriguez, and Mar ia J. Garc ia-Barcina* Department of Otolaryngology, Basurto University Hospital (OSAKIDETZA/Servicio Vasco de Salud), University of the Basque Country (UPV/EHU), Bilbao, Spain Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain Department of Genetics, Basurto University Hospital (OSAKIDETZA/Servicio Vasco de Salud), Bilbao, Spain Department of Genetics, Physical Anthropology and Animal Physiology. University of the Basque Country (UPV/EHU), Bilbao, Spain


Medicina Oral Patologia Oral Y Cirugia Bucal | 2015

Efficacy of mandibular advancement device in the treatment of obstructive sleep apnea syndrome: a randomized controlled crossover clinical trial

Joaquín Durán-Cantolla; Rafael Crovetto-Martínez; Mohammad-Hamdan Alkhraisat; Miguel Ángel Crovetto; Antonio Municio; Ramón Kutz; Felipe Aizpuru; Erika Miranda; Eduardo Anitua

Background Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. Material and Methods A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (PD) defined as a splint in the centric occlusion that did not induce a mandibular advancement served as a control. The mandible was advanced to the maximum tolerable distance or to a minimum of 65% of the maximum protrusion. After each sequence of treatment, patients were assessed by questionnaires, conventional polysomnography, and objective measurement of snoring at the patient’s own home. Results Forty two patients participated in the study and 38 completed the study. Patients mean age was 46 ±9 years and the 79% were males. The mean mandibular advancement was 8.6 ±2.8 mm. Patients used the MAD and the PD for 6.4 +2.4 hours and 6.2 +2.0 hours, respectively. Secondary effects (mostly mild) occurred in the 85.7% and the 86.8% of the users of MAD and PD, respectively. The MAD induced a decrease in the apnea-hypopnea index (AHI) from 15.3 +10.2 to 11.9 +15.5. The 50% reduction in the AHI was achieved in the 46.2% and the 18.4% of the patients treated with MAD and PD, respectively. The use of the MAD induced a reduction in the AHI by 3.4 +15.9 while the PD induced an increase by 10.6 +26.1. The subjective evaluation of the roncopathy indicated an improvement by the MAD and an increase in the perceptive quality of sleep. However, the objective evaluation of the roncopathy did not show significant improvements. Conclusions The use of MAD is efficient to reduce the AHI and improve subjectively the roncopathy. MAD could be considered in the treatment of mild-to-moderate OSA and chronic roncopathy. Key words:Obstructive sleep apnea (OSA), mandibular advance device, treatment, efficacy, clinical assay.


Acta otorrinolaringológica española | 2013

Influencia de la existencia de una dehiscencia en un canal semicircular en el espesor óseo de los canales contralaterales

Borja Gracia-Tello; Ana Cisneros; Rafael Crovetto; Claudio Martínez; Olívia Rodriguez; Iñigo Lecumberri; Miguel Ángel Crovetto; Jaime Whyte

OBJECTIVES Our objective was to determine if the existence of dehiscence in the superior or posterior semicircular canal was associated with the thinning of the bone roof in the rest of the vertical canals (superior or posterior). METHODS The thickness of the superior and posterior semicircular canals contralateral to a dehiscence was studied using computerized tomography and compared statistically. RESULTS When a superior semicircular canal had a dehiscence, the contralateral canal showed a significant mean decrease in its thickness of 0.5mm (SD: 0.3 mm). This was not the case if the dehiscence was in the posterior semicircular canal, where the thickness of 2.1 mm remained unchanged (SD: 1.2 mm; P=.49). When a posterior semicircular canal showed dehiscence, no significant thinning was shown in the superior semicircular (1 mm; SD: 0.4) or in the posterior contralateral (1.3 mm; SD: 0.3) canals. CONCLUSION The existence of a dehiscence in the superior semicircular canal is associated with bone thinning in the canal on the opposite side, but not with the posterior semicircular canal. In contrast, if the dehiscence is in the posterior semicircular canal, contralateral and superior canal thickness is not modified.


Otology & Neurotology | 2016

Association Between Tegmen Tympani Status and Superior Semicircular Canal Pattern.

Jaime Whyte; M.T. Tejedor; Jesús Fraile; Ana Cisneros; Rafael Crovetto; L.V. Monteagudo; Ana Whyte; Miguel Ángel Crovetto

Objective: Detecting and quantifying the possible association between tegmen tympani (TT) status and superior semicircular canal (SSC) pattern. Design: Observational study. Setting: Study conducted in three tertiary Spanish hospitals. Patients: Nonselected consecutive patients of all ages (607 temporal bones). Interventions: Thin-section multidetector row computed axial tomography (CAT scan) of the temporal bones. Main Outcome Measure: Thickness of SSC bone coverture adjacent to the middle fossa, and TT status as a dichotomous variable: dehiscence (TTD) or integrity (TTI). Results: The observed SSC patterns were dehiscence (3.79%), papyraceous or thin (11.20%), normal (76.77%), thick (4.94%), and pneumatized (3.29%). The observed TT statuses were TTD (10.87%) and TTI (89.13%). TTD was associated with SSCD and papyraceous patterns, and TTI percentages were higher in normal and thick patterns (&khgr;2 = 11.102; p = 0.001). The TTD probability was estimated as a function of SSC pattern and age by a multivariate binary logistics regression model (&khgr;2 = 45.939; p < 0.001). Conclusion: SSC pattern was significantly associated with TT status. Age influenced this association. The risk for TTD increased by 4.1% per each year of increasing age, did not differ significantly for normal and thick patterns, and increased 12 times and 20 times for papyraceous and SSCD patterns, respectively.


Otology & Neurotology | 2013

Congenital dehiscence in the posterior semicircular canal.

Jaime Whyte; Ana Cisneros; Claudio Martínez; Borja Gracia-Tello; Ana Whyte; Rafael Crovetto; Miguel Ángel Crovetto

Hypothesis Posterior semicircular canal dehiscence (PSCD) may be of congenital origin. Background PSCD is characterized by the lack of bone coverage, which results in its lumen being exposed to the meninges of the posterior cranial fossa or to the gulf of the jugular vein. It has an incidence of 0.2%. Its presence has been associated with several well-defined entities, although a congenital origin has not been proven. Methods We have analyzed, from a macroscopic, microscopic, and radiologic (computed tomography) viewpoint, the right temporal bone of a 32-week-old human fetus that presented a defect in the bone coverage located in the rear. Results The macroscopic study showed a solution of continuity in the posterior semicircular canal, with elliptic morphology and smooth edges. This defect was 3.4 mm long with a width that varied between 0.67 mm in its apical portion and 1.42 in the basal portion. The radiologic study (computed tomography) showed the absence of bone coverage of the posterior semicircular canal, which was open to the intracranial space in the posterior fossa. Its histologic study showed good bone coverage of this canal at the expense of compact bone tissue. However, at the medial end, there is a lack of bone coverage, resulting in the lumen of the canal being open to the intracranial space. The bone edges of the defect did not present any osteoclast activity. Conclusion The lack of bone coverage (dehiscence) of the posterior semicircular canal in a 32-week-old fetus suggests a congenital component of bony dehiscences of this canal. Even so, this single finding does not conclusively prove the congenital component, and the dehiscence is a finding that can be part of and not by itself a syndrome.


Acta otorrinolaringológica española | 2014

Peculiaridades en el desarrollo del canal semicircular superior

Carmen Yus; Ana Cisneros; Jesús Obón; Rafael Crovetto; Jesús Fraile; Miguel Ángel Crovetto; Jaime Whyte

OBJECTIVE Our objective was to study the ontogeny of the superior semicircular canal in order to describe its peculiarities. METHODS We analyzed 76 series of human embryos aged between 32 days (6mm) and newborns. The samples were cut serially and stained using Martins trichrome technique. RESULTS In semicircular canal development there were a number of peculiarities, such as: a defined chronological sequence of osteogenesis with a variable rate of ossification; the fact that each nucleus of ossification was involved in the formation of one of its covers (the upper in the superficial and the lower in the deep); the appearance of transitory dehiscence; and canal closure by means of bone with laminar pattern, with a minimum thickness of 0.1mm. CONCLUSION The peculiarities in canal development could explain the origin of pathological dehiscence in the canal, whether congenital or acquired.


Acta otorrinolaringológica española | 2011

Defecto de cobertura del canal semicircular superior y su implicación clínica

Jaime Whyte Orozco; Claudio Martínez; Ana Cisneros; Jesús Obón; Borja Gracia-Tello; Miguel Ángel Crovetto

INTRODUCTION AND OBJECTIVE The aetiology of the superior semicircular canal dehiscence is currently unknown. Our objective was to analyse and discuss different hypotheses about the origin of this pathology. METHODS In this study performed on 295 temporal bones, one case of partial alteration of the bony roof in the right superior semicircular canal was described from the anatomical and radiological points of view, and compared with the temporal bone on the other side. RESULTS Macroscopically, the superior semicircular canal shows deterioration in the bony roof, which consists exclusively of the inner or endosteal layer that separates the canal from the superior semicircular conduct. The Pöschl plane reconstruction showed a whole bony roof, but its thickness decreased from the canal curvature to the defect (from 0.6 to 0.3mm). CONCLUSION The presence of partial defects in the bony roof of the superior semicircular canal with absence of the external and middle layers, besides its lesser thickness, makes the canal susceptible to suffering a second event. This could produce its fracture and a dehiscence.


Acta otorrinolaringológica española | 2016

Explicación ontogénica para la asociación entre dehiscencia del tegmen tympani y dehiscencia del canal semicircular superior

Jesús José Fraile Rodrigo; Ana Cisneros; Jesús Obón; Carmen Yus; Rafael Crovetto; Miguel Ángel Crovetto; Jaime Whyte

OBJECTIVES To analyze the ontogeny of the superior semicircular canal and tegmen tympani and determine if there are common embryological factors explaining both associated dehiscence. METHODS We analyzed 77 human embryological series aged between 6 weeks and newborn. Preparations were serially cut and stained with Massons trichrome technique. RESULTS The tegmental prolongation of tegmen tympani and superior semicircular canal originate from the same structure, the otic capsule, and have the same type of endochondral ossification; while the extension of the squamous prolongation of tegmen tympani runs from the temporal squama and ossification is directly of intramembranous type. The nuclei of ossification of the superior and external semicircular canals and accessory of tegmen collaborate in the ossification of the tegmental extension and by growth extend to the tegmental prolongation. This fact plus the fact that both structures share a common layer of external periosteum could explain the coexistence of lack of bone coverage in tegmen and superior semicircular canal. CONCLUSION The development of the semicircular canal and tegmen tympani could explain the causes of the association of both dehiscences.

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Jaime Whyte

University of Zaragoza

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Rafael Crovetto

University of the Basque Country

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Ana Whyte

University of Zaragoza

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Jose Antonio Rodriguez

University of the Basque Country

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