Miguel Ángel Pérez-Nieto

The Australian contribution to the literature on atypical antipsychotic drugs: a bibliometric study

Objective: We performed a bibliometric study on scientific publications on atypical antipsychotic drugs (AADs) from Australia. Methods: Using the EMBASE and MEDLINE databases, we chose those documents produced in Australia between 1993 and 2011, whose title included the descriptors atypic* (atypical*), antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone, lurasidone, perospirone and blonanserin. We applied bibliometric indicators of production as well as dispersion. Results: We identified 438 relevant publications. The most widely studied AADs were clozapine (162 documents), olanzapine (103), risperidone (77) and quetiapine (42). There was a lack of exponential growth in publications over time, indicated by non-fulfilment of Price’s Law (correlation coefficient r=0.9195 after exponential adjustment vs. r=0.9253 after linear adjustment). Publications appeared in 148 different journals, with four of the top nine journals having an impact factor greater than 3; 84 of the articles appeared in the Australian and New Zealand Journal of Psychiatry. Conclusion: Despite Australian publications on AADs appearing in reasonably high impact journals, most were confined to a single Australian psychiatry journal and overall publications did not show exponential growth over the period studied. This might reflect, inter alia, the relative paucity of medication trials being performed in Australia.

Trends in Scientific Literature on Atypical Antipsychotics in South Korea: A Bibliometric Study

Objective We have carried out a bibliometric study on the scientific publications in relation to atypical or second-generation antipsychotic drugs (SGAs) in South Korea. Methods With the EMBASE and MEDLINE databases, we selected those publications made in South Korea whose title included the descriptors atypic* (atypical*) antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone, lurasidone, perospirone and blonanserin. We applied some bibliometric indicators of paper production and dispersion with Prices law and Bradfords law, respectively. We also calculated the participation index (PI) of the different countries, and correlated the bibliometric data with some social and health data from Korea (such as total per capita expenditure on health and gross domestic expenditure on research and development). Results We collected 326 original papers published between 1993 and 2011. Our results state fulfilment of fulfilled Prices law, with scientific production on SGAs showing exponential growth (correlation coefficient r=0.8978, as against an r=0.8149 after linear adjustment). The most widely studied drugs were risperidone (91 papers), aripiprazole (77), olanzapine (53), and clozapine (43). Division into Bradford zones yielded a nucleus occupied by the Progress in Neuro-Psychopharmacology and Biological Psychiatry (36 articles). A total of 86 different journals were published, with 4 of the first 10 used journals having an impact factor being greater than 4. Conclusion The publications on SGAs in South Korea have undergone exponential growth over the studied period, without evidence of reaching a saturation point.

International Scientific Productivity on Second-Generation Antipsychotic Drugs in Taiwan: A Bibliometric Study

Background: This is a bibliometric study on the scientific papers of second generation (atypical) antipsychotic drugs (SGAs) from Taiwan. Methods: With the EMBASE and MEDLINE databases, we chose the published documents from Taiwan with the descriptors of atypical*, antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone and lurasidone. We used bibliometric indicators of production and dispersion, i.e., Prices law on the increased scientific papers, and Bradfords law on dispersion. We also calculated the participation index of the different countries, and correlated those bibliometric data with some social and health data from Taiwan (such as total per capita expenditure on health and overall volume of production in the field of Psychiatry and Neurology). Results: We downloaded 359 SGA-related original documents published from 1993 to 2011:29.53% of them were dealt with clinical efficacy and 40.11% tolerance and safety. Our study results fulfilled Prices law, that scientific SGA papers showed exponential growth (r = 0.9601, as against an r = 0.9305 after linear adjustment). OfSGA publications, the drugs most studied are clozapine (89 papers), risperidone (82), aripiprazole (74), olanzapine (62), and quetiapine (22). Division of the results into Bradford zones yielded a nucleus published exclusively in the Progress in Neuro-Psychopharmacology and Bio logical Psychiatry (56 articles). All papers from Taiwan were published in 90 different journals, and 8 of the first 10 most often published journals for Taiwanese papers have an impact factor being greater than 2. Conclusion: The published SGA papers from Taiwan have been growing exponentially from 1933-2011, without any evidence of reaching a saturation point.

Negative affect in systemic sclerosis

Abstract Negative affect appears frequently in rheumatic diseases, but studies about their importance and prevalence in systemic sclerosis patients are scarce, and the results are inconclusive separately. We conducted a comprehensive search on April 2013 of PubMed, Medline, and PsycINFO databases to identify original research studies published. A total of 48 studies were included in this systematic review. We found negative emotions have very high levels in these patients, compared to both healthy population other chronic rheumatic patients assessed with the same instruments and cutoffs. Depression has been, of the three negative emotions that we approach to in this review, the most widely studied in systemic sclerosis, followed by anxiety. Despite the fact that anger is a common emotion in these diseases is poorly studied. Methodologic issues limited the ability to draw strong conclusions from studies of predictors. Disease-specific symptoms (swollen joints, gastrointestinal and respiratory symptoms and digital ulcers) and factors related to physical appearance were associated with negative emotions. Interdisciplinary care and biopsychosocial approach would have a great benefit in the clinical management of these patients.

Stress induced by the socially evaluated cold-pressor test cause equivalent deficiencies of sensory gating in male subjects with schizophrenia and healthy controls

It is known that patients with schizophrenia show a deficiency in the prepulse inhibition reflex (PPI). These patients display abnormalities in autonomic nervous system and hypothalamic-pituitary-adrenal function and may have an altered sensitivity to stress. To date, no studies have been carried out to determine the effect of acute stress on the PPI. We investigated whether there was a differential response in reactivity to acute stress caused by the socially evaluated cold-pressor test (SECPT) in a sample of 58 chronic male patients with schizophrenia and 28 healthy control subjects. PPI, salivary cortisol and heart rate (HR) were measured. The patients were evaluated in two sessions (with and without the SECPT) 72 h apart and basal measurements were carried out and 30 min post-startle probe. We found an increase in salivary cortisol levels and the HR with SECPT condition in both groups and a significantly lower PPI% in patients with schizophrenia. The most relevant findings of this study are that the impairment of the PPI is increased by stress. Stress-induced increase in cortisol in both groups, mainly in healthy control group which allows us to hypothesize that at least such deterioration may be due to the hypercortisolemia caused by the SECPT.

The role of rumination in the guilt associated with bereavement according to cause of death

The purpose of this study was to analyse the role rumination plays in the relationship between cause of death and the guilt present during bereavement. The sample consisted of 90 people that had suffered a loss due to an expected or unexpected natural death, suicide or accident. The results suggest that rumination increases the levels of guilt felt by people that had suffered a loss due to suicide compared to those whose loss was due to an expected natural death. These findings contribute to a better understanding of the mechanisms with an influence on bereavement.

SAT0647-HPR Patient Personality Influences The Prescription of Treatment for Rheumatoid Arthritis

Background Individualized treatment of rheumatoid arthritis (RA) based on genetic and serologic factors is increasingly accepted. In addition, patients are more actively involved in the management of their disease. However, personality has received little attention with respect to perception of the need and adherence to treatment. Objectives Our objective was to evaluate the influence of personality on the intensity of RA treatment. Methods We performed a cross-sectional study in two hospitals with early arthritis clinics where sociodemographic, clinical, and therapeutic variables are systematically recorded. Patients completed Eysenck Personality Questionnaire, Multidimensional Health Locus of Control, Pain-Related Self-Statement Scale and Pain-Related Control Scale. Aggressive treatment was considered if patients received more than two DMARDs or biological agents during the first year of follow-up. Multivariate logistic regression analysis was performed to determine predictors of aggressive treatment. Results 176 RA patients were included (80% women, disease begin median age 55 years). Treatment was considered aggressive in 57.9% of the sample. Scores were high in extraversion in 50.8% of patients, neuroticism in 29.5%, and psychoticism in 14.7%.Neuroticism was the only factor associated with aggressive treatment, which was less probable (p=0.04, OR =0.40). Neuroticism also decreased the possibility of receiving a combination of biologics and DMARDs (p=0.04, OR =0.28). Conclusions Patients with high scores on neuroticism are more worried, obsessive and hypochondriac, leading them to reject more aggressive therapy. It is important educate patients about their disease so that they will accept more aggressive approaches in clear cases of poor outcome. Disclosure of Interest None declared

AB0829-HPR Influence of ra patient personality for more aggressive therapies

Background Actually, patients with rheumatoid arthritis (RA) play a more active role in relation to his illness, and the choice of treatment. The patient’s personality can be an important part in this process. Few studies associate medical characteristics of the patient with prognosis and treatment. However, for the evaluation of RA using self-administered questionnaires (eg HAQ) or the patient’s own assessment (DAS28), which are being influenced by patient characteristics such as personality. Objectives To evaluate the influence of personality factors in the type of treatment that patients receive. Methods Multicenter study of a cohort of patients with RA, with a crossover design. We selected patients diagnosed RA of recent onset in two hospitals, with a maximum follow-up of 18 months. All patients who consented completed a form that included general sociodemographic variables, the Eysenck Personality Questionnaire (EPQ-A), Locus of Control Health-related questionnaire (MHLC), and Beliefs and Self-statements about Pain questionnaire (PRCS / PRSS). Also collected measures of disease activity (DAS28 and CRP in the first year after diagnosis). Aggressive treatment was considered to have received more than two DMARDs, or Biological, during follow up. A descriptive analysis of the variables associated with more aggressive treatment and a logistic regression analysis to determine personality variables associated with treatment, adjusting for sociodemographic and clinical characteristics were performed. Results A total of 176 RA patients were included in the study. 80% of the sample was women. The mean age was 55.7 ± 13.2 years. The 48.8% of the sample received aggressive treatment. The 50.89% of patients had high scores on extraversion, and 28.7% scored high in neuroticism. We do not found significant differences in age and sex related to aggressive treatment. We performed a multivariate logistic regression analysis, finding that the personality trait of neuroticism is the only predictor of receiving more aggressive treatment (p = 0.01, OR = 0.34). Conclusions Patients with high scores on neuroticism are more worried, anxious and / or depressed, affecting their assessment of the disease and may influence the increased demand for therapeutic resources. Disclosure of Interest None Declared