Miji Choi

Rhodium-Catalyzed C–H Alkylation of Indolines with Allylic Alcohols: Direct Access to β-Aryl Carbonyl Compounds

The rhodium(III)-catalyzed site-selective C-H alkylation of various N-heterocycles, such as indolines, carbazoles, and pyrroles with readily available allylic alcohols is described. This protocol allows the generation of a heterocyclic scaffold containing a β-aryl carbonyl moiety, which is known to be a crucial structural unit of biologically active compounds.

Synthesis of N-Sulfonylamidated and Amidated Azobenzenes under Rhodium Catalysis.

The rhodium(III)-catalyzed ortho-C-H amidation of azobenzenes with arylsulfonyl and aryl and alkyl isocyanates is described. The N-sulfonyl amidation reaction using arylsulfonyl isocyanates is first reported in the C-H activation strategy. These transformations provide the facile and efficient construction of a range of amide moieties into azobenzenes.

Trifluoromethylallylation of Heterocyclic C–H Bonds with Allylic Carbonates under Rhodium Catalysis

The rhodium(III)-catalyzed γ-trifluoromethylallylation of various heterocyclic C-H bonds with CF3-substituted allylic carbonates is described. These reactions provide direct access to linear CF3-containing allyl frameworks with complete trans-selectivity via C-H bond activation followed by a formal SN-type reaction pathway.