Mikhail Menis

Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010

BACKGROUND: Thrombotic events (TEs) are rare but often serious adverse events that could occur after administration of immune globulin (IG) products. Our study objective was to assess occurrence of recorded TEs after administration of different US‐licensed IG products and investigate potential risk factors using a large administrative database.

Blood use by inpatient elderly population in the United States

BACKGROUND: Our objective was to characterize inpatient blood use by the US elderly population during 2001. As the US population ages the demand for blood is expected to grow. There have been no comprehensive studies, however, detailing blood use by the elderly in the United States.

Outpatient transfusions and occurrence of serious noninfectious transfusion-related complications among US elderly, 2007-2008: utility of large administrative databases in blood safety research.

BACKGROUND: Transfusion‐related acute lung injury (TRALI) and hemolytic transfusion reactions account for significant transfusion‐related morbidity and mortality in the United States. Our study evaluated types and quantities of transfused components as well as occurrence of TRALI, ABO, and Rh incompatibilities among the US elderly in the institutional outpatient setting during 2007 to 2008.

Immune globulins and same-day thrombotic events as recorded in a large health care database during 2008 to 2012.

Thrombotic events (TEs) are rare and serious adverse events after administration of immune globulin (IG) products. Our study evaluated the occurrence of same‐day TEs for different IG products and ascertained potential risk factors.

Clotting factor product administration and same‐day occurrence of thrombotic events, as recorded in a large healthcare database during 2008–2013

Thrombotic events (TEs) are serious adverse events that can occur following administration of clotting factors (CFs).

Babesiosis among Elderly Medicare Beneficiaries, United States, 2006–2008

We used administrative databases to assess babesiosis among elderly persons in the United States by year, sex, age, race, state of residence, and diagnosis months during 2006–2008. The highest babesiosis rates were in Connecticut, Rhode Island, New York, and Massachusetts, and findings suggested babesiosis expansion to other states.

Blood use in the ambulatory setting among elderly in the United States

BACKGROUND: Our study characterizes blood use in the ambulatory setting by US elderly Medicare beneficiaries during 2001. As the US population ages and delivery of health care in outpatient settings is on the rise, ambulatory blood utilization is expected to increase. There is currently a lack of broad population‐based studies detailing ambulatory blood utilization patterns among the US elderly.

Occurrence of hemolytic reactions on the same day as immune globulin product administrations during 2008 to 2014

Hemolytic reactions (HRs) are rare serious adverse events after immune globulin (IG) use. Our large claims‐based study evaluated occurrence of same‐day hemolysis after administration of different IG products and potential risk factors, during the 2008 to 2014 study period.

Occurrence of acute renal failure on the same day as immune globulin product administrations during 2008 to 2014

Acute renal failure (ARF) is a rare serious adverse event after immune globulin (IG) use. Our large claims‐based study evaluated occurrence of same‐day ARF after administration of different IGs and ascertained potential risk factors, during the 2008 to 2014 study period.

Modeling the potential impact on the US blood supply of transfusing critically ill patients with fresher stored red blood cells

Background Although some studies have suggested that transfusion recipients may have better medical outcomes if transfused with red blood cell units stored for a short time, the overall body of evidence shows mixed results. It is important to understand how using fresher stored red blood cell units for certain patient groups may affect blood availability. Methods Based on the Stock-and-Flow simulation model of the US blood supply developed by Simonetti et al. 2014, we evaluated a newly implemented allocation method of preferentially transfusing fresher stored red blood cell units to a subset of high-risk group of critically ill patients and its potential impact on supply. Results Simulation results showed that, depending on the scenario, the US blood total supply might be reduced between 2-42%, when compared to the standard of care in transfusion medicine practice. Among our simulated scenarios, we observed that the number of expired red blood cell units modulated the supply levels. The age threshold of the required red blood cell units was inversely correlated with both the supply levels and the number of transfused units that failed to meet that age threshold. Conclusion To our knowledge, this study represents the first attempt to develop a comprehensive framework to evaluate the impact of preferentially transfusing fresher stored red blood cells to the higher-risk critically ill patients on supply. Model results show the difficulties to identify an optimal scenario.