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Dive into the research topics where Mikihiro Goto is active.

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Featured researches published by Mikihiro Goto.


Japanese Journal of Applied Physics | 2013

Analysis of Mass Loading Effect on Guided Shear Horizontal Surface Acoustic Wave on Liquid/Au/Quartz Structure for Biosensor Application

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

A numerical analysis of a shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor has been investigated. The numerical calculation method proposed by Campbell and Jones has generally been used to calculate SAW propagation characteristics. In this paper, a numerical calculation method for SH-SAW propagation characteristics, which is a modified method of Campbell and Jones involving the effect of liquid viscosity is applied to quartz. A mass loading sensitivity of a 250 MHz SH-SAW delay-line biosensor was calculated and compared with the experimental results. It can be concluded from the results that viscosity sensitivity is dominant over mass loading sensitivity for 250 MHz SH-SAW biosensors.


internaltional ultrasonics symposium | 2010

Point-of-care SH-SAW biosensor

Mikihiro Goto; Osamu Iijima; Takashi Kogai; Hiromi Yatsuda

This paper describes a two-channel liquid-phase shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor. The sensor device was designed using a 250MHz SH-SAW delay-line on Quartz substrates, which is composed of a transmitting and receiving transducers and a biochemical reaction area in between them. Those transducers are protected from liquids by a glass lid and epoxy walls which are constructed using a photo-lithography technique. So the sensor devices can be directly dipped into a liquid and a liquid can be directly applied onto the surface of the sensor device. A two-channel delay-line design technique can effectively suppress unwanted bulk wave spurious signals. On the other hand, in order to detect the mass and viscosity changes of the antigen-antibody reactions on the surface of the sensor device, a prototype electric reader having measurement circuits was realized with 14 × 10 × 4 cm3 in size. The reader has a burst circuit to eliminate unwanted electromagnetic feed through signals. A model immunoassay based upon human serum albumin detection was used to assess suitability of point-of-care testing applications.


internaltional ultrasonics symposium | 2012

Numerical analysis of liquid-phase SH-SAW biosensor on quartz

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

This paper describes a numerical analysis for the shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor. A numerical calculation method which was proposed by Campbell and Jones has been generally used to calculate SAW propagation characteristics. In this paper, a numerical calculation method for SH-SA W propagation characteristics is proposed, which is an improved Campbell and Jones method involving an influence of liquid viscosity. In order to confirm the proposed numerical analysis, 250 MHz SH-SA W delay-lines on quartz substrates were tested using glycerol-water mixed liquids of different concentrations of 0, 10, 20 and 30 wt%. In the experiments, the velocity changes and attenuation changes of the SH-SA Ws were increased increment in glycerol concentrations as theoretically expected. Very good agreements between theoretical and experimental results were obtained.


Japanese Journal of Applied Physics | 2007

Power Flow Angles for Slanted Finger Surface Acoustic Wave Filters on Langasite Substrate

Mikihiro Goto; Hiromi Yatsuda; Takao Chiba

Power flow angles (PFAs) on a langasite (LGS) substrate with Euler angles of (0°, 138.5°, ψ), ψ=25.7 to 27.7° are investigated for slanted finger interdigital transducer (SFIT) surface acoustic wave (SAW) filters by an electrical and optical methods. In the electrical method, several tilted SFIT SAW filters with different tilt angles for (0°, 138.5°, ψ) LGS substrates were designed, and the frequency responses of the filters were measured. In the optical method, the PFAs were directly measured by optical probing for a parallel interdigital transducer (IDT) with wide propagation area on the substrate. As a result, a good correlation between electrical and optical measurements of the PFAs is obtained, but the calculated PFAs are slightly different from the measured PFAs. A good frequency response of a tilted 380 MHz SFIT SAW filter with an appropriate tilt angle corresponding to the PFA on the substrate is obtained even though the aperture is small.


Japanese Journal of Applied Physics | 2015

Effect of viscoelastic film for shear horizontal surface acoustic wave on quartz

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

A numerical analysis for the mass loading sensitivity of shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensors on quartz has already been studied. However, the mass loading analysis is insufficient to explain the actual biosensor performance. To understand the SH-SAW biosensor performance, we analyze the effect of a viscoelastic film on SH-SAW biosensors. In this paper, a numerical analysis using a simple viscoelastic model for the SH-SAW biosensors is presented. In the theoretical model, the bioreaction layer on the SH-SAW biosensors can be treated as a viscoelastic film. The velocity changes of the 250 MHz SH-SAWs on quartz substrates, which are covered with bovine serum albumin (BSA) layers of different thicknesses, were measured and compared with the theoretical results obtained using the proposed viscoelastic model. Good agreement of the velocity changes of SH-SAWs versus changes in the viscoelastic film thickness between theoretical and experimental results was obtained.


international frequency control symposium | 2014

Shear-horizontal surface acoustic wave biosensors for POCT

Hiromi Yatsuda; Takashi Kogai; Mikihiro Goto; Naoyuki Yoshimura

An immunoassay-based biosensor using shear horizontal surface acoustic wave (SH-SAW) devices for point-of-care-testing (POCT) applications is described. The SH-SAW biosensor is composed of a disposable SH-SAW biosensor chip and an electrical reader connected to the biosensor chip. The biosensor chip is a quartz-based 250 MHz SH-SAW delay-line which has a gold surface covered with antibodies. A palm-sized electric reader connected to a smart-phone for detecting antigen-antibody reactions has been demonstrated. In this paper, a unique air-cavity structure and a reflection type delay-line design for the SH-SAW biosensor chip are described. The SH-SAW biosensor must be a strong candidate for future home healthcare applications.


internaltional ultrasonics symposium | 2013

Optimization of gold film thickness for SH-SAW biosensor on quartz

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

This paper describes a numerical analysis for the shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor. The numerical calculation method proposed by Campbell and Jones has generally been used to calculate SAW propagation characteristics. In this paper, a numerical calculation method for SH-SAW propagation characteristics, which is a modified method of Campbell and Jones involving the effect of liquid viscosity is applied to quartz. The effect of the immunization reaction can be equivalent to viscosity changes of a liquid. Some experimental results using SH-SAW sensors on quartz with different gold film thickness are also shown for comparison with the numerical calculation results.


internaltional ultrasonics symposium | 2006

6B-5 Optimum Design for Slanted Finger SAW Filters on Langasite Substrate

Mikihiro Goto; Hiromi Yatsuda; Takao Chiba

Power flow angles (PFAs) on the langasite (LGS) substrate with Euler angle of (0deg, 138.5deg,Psi), Psi = 25.7deg to 27.7deg are investigated for slanted finger interdigital transducer (SFIT) SAW filters to realize an optimum design. A tilted 380 MHz SFIT SAW filter with an aperture of 40 wavelengths and number of finger pairs of 500 for input and 300 for output is designed for the appropriate PFA of the substrate and a good frequency response is obtained


international frequency control symposium | 2016

SH-SAW biosensor on quartz

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

This paper describes a shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor on a quartz substrate. The SH-SAW biosensor is a 250MHz SH-SAW delay-line which has a gold surface covered with antibodies. It is important to discuss the detection mechanism of SH-SAW biosensors on quartz. In this paper, the detection mechanism of SH-SAW biosensors are investigated, using three methods of numerical analysis. The first method is a mass loading model analysis. The second method is a viscosity model analysis. The third method is a viscoelasticity model analyasis. A numerical calculation method for SH-SAW propagation characteristics, which is a modified Campbell and Jones method involving the effect of liquid viscosity is applied to quartz. In order to confirm the proposed numerical analysis models, 250MHz SH-SAW biosensors on quartz substrates were tested. The mass, viscosity, and viscoelastic behavior of fluids on SH-SAW biosensors were theoretically and experimentally discussed.


international frequency control symposium | 2014

380MHz SH-SAW biosensors

Mikihiro Goto; Hiromi Yatsuda; Jun Kondoh

The velocity and attenuation changes of shear horizontal surface acoustic wave (SH-SAW) biosensors with viscosity changes as a function of the operating frequencies are studied. It is confirmed that the velocity and attenuation changes of SH-SAW biosensors to the viscous changes are proportional to the square root of the frequency using the numerical calculations and experimental results. On the other hand, there are two more design parameters to determine a sensitivity of the SH-SAW biosensors, the gold film thickness of the propagation area and the length of the propagation area. A 380MHz SH-SAW biosensor is designed and fabricated on quartz substrates, and tested using different concentrations of glycerol mixtures. Very good agreements between theoretical and experimental results were obtained.

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