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Dive into the research topics where Mikkel Jessing is active.

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Featured researches published by Mikkel Jessing.


Bioorganic & Medicinal Chemistry | 2015

BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitors

Alexandru Vlasceanu; Mikkel Jessing; John Paul Kilburn

The application of BN/CC isosterism is explored as a method of expanding the scope of core scaffolds in biologically active compounds. The viability of potential drug candidates incorporating BN-heteroaromatic moieties was investigated through the synthesis of BN-substituted analogs to known phosphodiesterase (PDE10A) inhibitors, namely MP10 and a selection of N-methylanilide analogs. These in some cases revealed unexpectedly potent and relatively stable derivatives, providing further support for the potential of BN-incorporation in medicinal chemistry.


Chemical Science | 2018

Fast and accurate prediction of the regioselectivity of electrophilic aromatic substitution reactions

Jimmy C. Kromann; Jan H. Jensen; Monika Kruszyk; Mikkel Jessing; Morten Jørgensen


Archive | 2017

Triazolopyrazinones as pde1 inhibitors

Jan Kehler; Lars Kyhn Rasmussen; Mikkel Jessing


Archive | 2015

N-(2-(cyclic amine)ethyl)benzamide derivatives as P2x7 inhibitors

John Paul Kilburn; Lars Kyhn Rasmussen; Mikkel Jessing; Eman Mohammed Eldemenky; Bin Chen; Yu Jiang


Archive | 2013

QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS

Jan Kehler; John Paul Kilburn; Jacob Nielsen; Ask Püschl; Morten Langgård; Mikkel Jessing; Mauro Marigo


Archive | 2018

IMIDAZOPIRAZINONAS COMO INHIBIDORES DE PDE1

Jan Kehler; Morten Langgård; Karsten Juhl; Lars Kyhn Rasmussen; Mikkel Jessing; Paulo Jorge Vieira Vital


Archive | 2018

COMBINATION TREATMENTS COMPRISING IMIDAZOPYRAZINONES FOR THE TREATMENT OF PSYCHIATRIC AND/OR COGNITIVE DISORDERS

Jan Kehler; Rasmussen Lars Kyhn; Morten Langgård; Mikkel Jessing; Vital Paulo Jorge Vieira; Karsten Juhl


Archive | 2018

TRAITEMENTS COMBINÉS COMPRENANT DES IMIDAZOPYRAZINONES POUR LE TRAITEMENT DE TROUBLES PSYCHIATRIQUES ET/OU COGNITIFS

Jan Kehler; Rasmussen Lars Kyhn; Morten Langgård; Mikkel Jessing; Vital Paulo Jorge Vieira; Karsten Juhl


Archive | 2017

derivados n-(2-(amina cíclica)etil)benzamida como inibidores de p2x7

Bin Chen; Eman Mohammed Eldemenky; John Paul Kilburn; Lars Kyhn Rasmussen; Mikkel Jessing; Yu Jiang


Archive | 2017

Benzamide-containing compounds and their use in the treatment of pain

John Paul Kilburn; Lars Kyhn Rasmussen; Mikkel Jessing; Eman Mohamed Eldemenky; Bin Chen; Yu Jiang; Allen T. Hopper

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