Miklós Nyerges

1,7-Electrocyclisations of stabilised azomethine ylides

Ester-stabilized a,b:g,d-unsatd. azomethine ylides were generated by the deprotonation method from isoquinolinium salts. 1,7-Electrocyclization of these dipoles followed by a 1,5-hydrogen shift, gives tetrahydro[5,6]azepino[2,1-a]isoquinolines I (R = MeO2C, PhCH2, PhCO, CH2:CHCH2).

Synthesis of New Quinoline Derivatives

Abstract The synthesis of some new functionalized quinolyl derivatives has been described, based on the 1,3‐dipolar cycloaddition of an azomethine ylide, generated from sarcosine or N‐benzylglycine and paraformaldehyde, to 2‐chloro‐3‐quinolinecarbaldehydes.

Synthesis of pyrrolo[3,4-c]quinolines by 1,5-electrocyclisation of non-stabilised azomethine ylides

A new route to the pyrrolo[3,4-c]quinoline ring system was developed via the 1,5-dipolar electrocyclization reactions of azomethine ylides derived from easily available 3-formylquinoline derivs. The intermediacy of azomethine ylides was shown by the trapping of the proposed dipoles with N-phenylmaleimide.

A convenient synthesis of pyrrolo[3,4-c]quinolines

Synthesis of Pyrrolo[3,4-c]quinolines Andrea Virányi,a Miklós Nyerges,*a Gábor Blaskó,b László Tőkea a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, 1521 Budapest P.O.B. 91, Hungary b EGIS Pharmaceuticals Ltd., 1475 Budapest P.O.B. 100, Hungary Fax +36(1)4633648; E-mail: mnyerges@mail.bme.hu Received 13 June 2003; revised 2 September 2003