Milos Rusek
Novartis
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Featured researches published by Milos Rusek.
Studies in Surface Science and Catalysis | 1991
Milos Rusek
Abstract We have developed a multimetallic catalyst for the large scale synthesis of sterically hindered mono-N-alkylanilines with very good selectivity and high catalytic activity. In contrast to copper chromite catalysts which allow the N-alkylation only with primary alcohols, the doubly promoted Pt/SiO 2 catalysts described here are useful for the reaction of ortho-substituted anilines with both primary and secondary alcohols. The catalyst must activate three reaction steps: Dehydrogenation of the alcohol, condensation of the aniline with the carbonyl compound produced and hydrogenation of the resulting imine to the desired N-alkylaniline. In the vapor phase the hydrogenation step is the most difficult to achieve under our reaction conditions. The effects of different metallic promoters (Sn, Ge, Re etc.) and of various basic additives on the performance of the catalyst are discussed. The best catalyst developed is a Pt-Sn/SiO 2 catalyst pretreated with Ca 2+ which is able to catalyze the alkylation of several ortho-disubstituted anilines with high conversions and selectivities.
The Journal of Physical Chemistry | 1986
Jean Francois Reber; Milos Rusek
Archive | 1982
Niklaus Buhler; Jean Francois Reber; Kurt Meier; Milos Rusek
Archive | 1992
Samuel Evans; Paul Dubs; Milos Rusek; Zdenek Mazour; Arpad Major
Archive | 2001
Bernd Siebenhaar; Milos Rusek
Archive | 1982
Paul Radimerski; Milos Rusek
Archive | 1982
Niklaus Buhler; Jean Francois Reber; Kurt Meier; Milos Rusek
Archive | 1987
Milos Rusek
Archive | 1984
Jean-Francois Reber; Niklaus Buhler; Kurt Meier; Milos Rusek
Archive | 1993
Beat M. Aebli; Daniel Monti; Milos Rusek