Miltiadis Aspiotis

Timing of dislocated nuclear fragment management after cataract surgery

Purpose: To determine the timing of vitrectomy in patients with dislocated nuclear fragments after phacoemulsification and to correlate timing with visual outcomes. Setting: University Eye Clinic of Ioannina, Ioannina, Greece. Methods: This was a retrospective review of the records of 26 patients who had phacoemulsification at the University Eye Clinic of Ioannina over a 5‐year period. The mean age of the 13 men and 13 women was 66.9 years (range 59 to 80 years). All patients had nucleus or nuclear fragment dislocation into the vitreous cavity during phacoemulsification and had vitrectomy and removal of the dislocated nucleus. The postoperative follow‐up ranged from 3 to 9 months. Results: Eight patients (30.8%) had vitrectomy at the time of phacoemulsification (Group A), 8 (30.8%) within 3 weeks (Group B), and 10 (38.5%) after more than 3 weeks (Group C). Patients in Group A did not develop complications, and 87.5% achieved a final visual acuity of 5/10 or better. In Group B, 4 patients (50%) developed moderate intraocular inflammation and 5 patients achieved a final visual acuity of 5/10 or better. Six patients in Group C (60%) had phacoanaphylactic glaucoma and 3 (30.0%), retinal detachment; 70.0% had a final visual acuity of 3/10 or worse. Conclusion: Early vitrectomy (fewer than 3 weeks postoperatively) was associated with better visual results, while late vitrectomy resulted in limited visual acuity in a high percentage of patients and increased the risk for glaucoma and retinal detachment.

Genetic linkage of autosomal dominant primary open angle glaucoma to chromosome 3q in a Greek pedigree

A locus for juvenile onset open angle glaucoma (OAG) has been assigned to chromosome 1q in families with autosomal dominant inheritance (GLC1A), due to mutations in the TIGR/MYOC gene. For adult onset OAG, called primary open angle glaucoma or POAG, five loci have so far been mapped to different chromosomes (GLC1B-GLC1F). Except for the GLC1B locus, the other POAG loci have so far been reported only in single large pedigrees. We studied a large family identified in Epirus, Greece, segregating POAG in an autosomal dominant fashion. Clinical findings included increased cup to disc ratio (mean 0.7), characteristic glaucomatous changes in the visual field, and intraocular pressure before treatment more than 21 mmHg (mean 31 mmHg), with age at diagnosis 33 years and older. Linkage analysis was performed between the disease phenotype and microsatellite DNA polymorphisms. Linkage was established with a group of DNA markers located on chromosome 3q, where the GLC1C locus has previously been described in one large Oregon pedigree. A maximal multipoint lod score of 3.88 was obtained at marker D3S1763 (penetrance 80%). This represents the second POAG family linked to the GLC1C locus on chromosome 3q, and haplotype analysis in the two families suggests an independent origin of the genetic defect.

Bartonella and intraocular inflammation: a series of cases and review of literature

Purpose: To present various forms of uveitis and/or retinal vasculitis attributed to Bartonella infection and review the impact of this microorganism in patients with uveitis. Methods: Retrospective case series study. Review of clinical records of patients diagnosed with Bartonella henselae and Bartonella quintana intraocular inflammation from 2001 to 2010 in the Ocular Inflammation Department of the University Eye Clinic, Ioannina, Greece. Presentation of epidemiological and clinical data concerning Bartonella infection was provided by the international literature. Results: Eight patients with the diagnosis of Bartonella henselae and two patients with B. quintana intraocular inflammation were identified. Since four patients experienced bilateral involvement, the affected eyes totaled 14. The mean age was 36.6 years (range 12–62). Uveitic clinical entities that we found included intermediate uveitis in seven eyes (50%), vitritis in two eyes (14.2%), neuroretinitis in one eye (7.1%), focal retinochoroiditis in one eye (7.1%), branch retinal vein occlusion (BRVO) due to vasculitis in one eye (7.1%), disc edema with peripapillary serous retinal detachment in one eye (7.1%), and iridocyclitis in one eye (7.1%). Most of the patients (70%) did not experience systemic symptoms preceding the intraocular inflammation. Antimicrobial treatment was efficient in all cases with the exception of the case with neuroretinitis complicated by anterior ischemic optic neuropathy and tubulointerstitial nephritis. Conclusion: Intraocular involvement caused not only by B. henselae but also by B. quintana is being diagnosed with increasing frequency. A high index of suspicion is needed because the spectrum of Bartonella intraocular inflammation is very large. In our study the most common clinical entity was intermediate uveitis.

Artisan aphakic intraocular lens implantation in cases of subluxated crystalline lenses due to Marfan syndrome.

PURPOSE To assess implantation of an Artisan aphakic intraocular lens (IOL) in cases with subluxated lenses due to Marfan syndrome. METHODS Retrospective study of a small case series comprised of seven eyes (two children and three adults) with subluxated lenses due to Marfan syndrome that underwent lens extraction and Artisan aphakic IOL implantation. Best spectacle-corrected visual acuity and endothelial cell status were the key elements of follow-up examinations. RESULTS No complications occurred during surgery. Visual acuity was improved by > or = 4 Snellen lines in all seven eyes. These results were maintained at the last follow-up. Endothelial cell status remained constant in all cases at 6-month follow-up. CONCLUSIONS In seven eyes with a subluxated crystalline lens due to Marfan syndrome, implantation of an Artisan aphakic IOL improved visual acuity while preserving anterior chamber status.

Factors influencing the accuracy of the SRK formula in the intraocular lens power calculation

Several intraocular lens (IOL) power calculation formulas (either theoretical or empirical) are used to determine the emmetropic IOL power) The Sanders-Retzlaff-Kraff (SRK) linear regression formula is among the most widely recognized empirical ones. In the present study intraocular lens power calculation aiming at emmetropia was performed, using SRK formula, in 145 cataractous eyes undergoing lens implantation. The final refraction was evaluated at 8 to 12 months after surgery. The purpose of this study was the identification and quantitative evaluation of the factors which influence significantly the accuracy of SRK in the intraocular lens power calculation. The following factors were studied: (1) the error in preoperative biometry with regard to the difference between post and preoperative axial length measurements, (2) the position of the implantation of the intraocular lens (anterior versus posterior chamber), (3) the intraocular lens style, (4) the intraocular lens power level, (5) the preoperative corneal astigmatism, (6) the surgically induced corneal astigmatism, and (7) the postoperative astigmatism. Multiple regression and stepwise regression analysis showed a strong correlation (R2 = 0.65;p < 0.001) between postoperative refractive error (Rf) and error in preoperative biometry (ΔAL), surgically induced corneal astigmatism (SIA) and postoperative astigmatism (Ap) only. This correlation is expressed by the following equation: Rf = 0.07 −2.55 ΔAL −0.42 SIA + 0.34 Ap. This equation indicates the quantitative effect of each factor on the accuracy of the SRK formula, by defining the pattern of the fluctuations of the amount or state (myopic or hyperopic) of refractive error induced by changes of variables ΔAL, SIA and Ap.

Primary mantle cell lymphoma of the conjunctiva: a case report.

Primary non-Hodgkin’s lymphomas of the conjunctiva are uncommon. They are almost exclusively extranodal marginal zone B-cell lymphomas/mucosa-associated lymphoid tissue lymphomas. In this study, we report an extremely rare case of conjunctival mantle cell lymphoma in a 78-year-old man, presenting as a unilateral epibulbar mass.

Juvenile idiopathic arthritis-associated uveitis: Data from a region in western Greece

Objective To evaluate the characteristics and visual prognosis of juvenile idiopathic arthritis-associated uveitis (JIA). Methods A retrospective review was performed on 56 patients who met the criteria for JIA to identify those with uveitis and related complications. Patients were referred to and were examined in the Pediatric Department of the University Hospital of Ioannina, between 1995 and 2007. Results The prevalence of JIA-associated uveitis was high. Despite this and the related complications, the final visual outcome was satisfactory in the majority of the cases. Authors did not observe any correlation between prognosis and sex, age at the onset of uveitis or arthritis, pattern of arthritis, or positivity for antinuclear antibodies (ANA). Conclusion We found a remarkably high prevalence of uveitis and related ocular complications in 7 (28%) of the patients, and the rate of poor visual outcome was 12%.

Multifocal Central Serous Chorioretinopathy Associated with Steroids in a Patient with Myasthenia Gravis

We present a case of bilateral multifocal central serous chorioretinopathy in a 40-year-old male who suffered from myasthenia gravis and was receiving oral prednisolone. Due to the severity of the underlying disease, it was not possible to reduce the corticosteroid dose. After initial unsuccessful treatment with an intravitreal injection of ranibizumab, low-fluence photodynamic therapy was performed, followed by gradual tapering of the corticosteroids. Visual acuity improved significantly in both eyes. Different therapeutic approaches are discussed.

Bilateral Mooren's Ulcer in Six Patients: Diagnosis, Surgery and Histopathology

We describe 6 bilateral cases of progressive Moorens ulcer treated by performing conjunctival excision (regional or 360° peritomy). The histopathological study of the conjunctiva adjacent to the lesion showed an hyperaemic and edematous stroma infiltrated mainly by plasma cells and lymphocytes without signs of vasculitis. The peripheral portion of the ulcer was characterized by necrobiotic and hemorrhagic elements along with an absence of the overlying epithelium and Bowmans membrane. Inflammation of the corneal stroma was present in the peripheral but absent in the central edge of the ulcer, a characteristic sign of a rodent ulcer. Therefore, the histopathological study was very useful for the final diagnosis and the differential diagnosis of Moorens ulcer from other cases of peripheral ulcerative keratitis. In all 6 cases conjunctival excision appeared to be an effective procedure in halting the progression of the disease: absence of recurrences during a follow-up period of 1–2 years provided an essential healing of the cornea.

Corneal Diameter as a Factor Influencing Corneal Astigmatism After Cataract Surgery.

Purpose: To evaluate the corneal horizontal diameter [white-to-white (WTW) distance] as a factor influencing surgically induced astigmatism (SIA) and postoperative astigmatism. Methods: A total of 330 eyes with corneal astigmatism ⩽1.5 D underwent cataract surgery with phacoemulsification. A 3-step, superotemporal for the right eye and superonasal for the left eye, clear corneal incision of 3.0 mm was made. Four groups were created according to WTW distance: group A ⩽11.6 mm, group B 11.7 to 11.9 mm, group C 12.0 to 12.2 mm, and group D ≥12.3 mm. SIA was calculated by vector analysis using the Alpins method. We noted all cases, in which a change greater than 0.5 diopters (D) in astigmatism took place and a change greater than 20 degrees in axis torque, despite axis direction, on the first and sixth postoperative months. Results: SIA was found in group A 0.98 D ± 0.6 (SD), B 0.79 D ± 0.43 (SD), C 0.68 D ± 0.45 (SD), and D 0.53 D ± 0.32 (SD) at the first postoperative month. At the sixth postoperative month, SIA was 0.77 D ± 0.43 (SD), 0.69 D ± 0.34 (SD), 0.62 ± 0.36 (SD), and 0.49 D ± 0.27 (SD), respectively. A change greater than 0.5 D in corneal astigmatic power at the first and sixth months postoperatively was significantly lower in eyes with WTW distance 12.0 to 12.2 mm and ≥12.3 mm in comparison with eyes with WTW distance ⩽11.6 mm and 11.7 to 11.9 mm (P < 0.05). Changes greater than 20 degrees in astigmatic axis at the first and sixth postoperative months were not significantly different according to the horizontal corneal diameter. Conclusions: WTW distance should always be measured preoperatively when planning cataract surgery and should be accounted for in cases of large and small corneas.