Milton Heller

The synthesis of some 21-chloro- 16α, 17α-acetonides

Abstract The preparation of several 21-chloro-11β-hydroxy-16ga, 17α-acetonides is described. The preparation of the analogous 9α, 11β-dichloro-acetonides is also given. The thymolytic activities of these compounds are discussed and tabulated.

The preparation and biological activity of 9α,11β-dichloro-21-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione

The preparation of 16α,21-diacetoxy-9α,11β-dichloro-17α-hydroxypregna-1,4-diene-3,20-dione (I) and 9α,11β-dichloro-21-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione (IIa) is described. The thymolytic activities of these and other 9α,11β-dichlorocorticoids are discussed.

An unusual dehydrogenation of steroidal Δ5(10),9(11)-dienes

Abstract Dehydrogenation of a Δ5(10),9(11)-3-keto Δ5(10),9(11)-3-hydroxy-steroid with 2,3-dichloro-5,6-dicyano- p -benzoquinone afforded the corresponding Δ4,9,11-3-ketone.