Min Kwon
Hoseo University
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Featured researches published by Min Kwon.
Environmental Health and Toxicology | 2011
Dong Seok Seo; Min Kwon; Ha Jung Sung; Cheol Beom Park
Objectives Tetrasodium pyrophosphate (TSP) is used in processed meat products, as an emulsifier in cheese, and as a color preservative in soybean paste. However, little is known about its toxicity. This study was conducted to investigate the potential acute and repeated dose toxicity of TSP in Spraque Dawley (SD) rats. Methods In the acute study, animals were administered with oral or dermal doses of 2,000 mg/kg TSP. In the repeated dose study, animals were administered doses of 0, 250, 500, and 1,000 mg/kg by oral gavage five times a week for 90 days. Results In acute toxicity studies, no dead animals or abnormal necropsy findings were found in the control or treated group. In the repeated dose toxicity study, there were no significant changes in body weight in the 1,000 mg/kg treatment group, or food consumption, urinalysis, and hematology in any group. With regards serum biochemistry, the levels of total protein, albumin, A/G ratio, triglyceride, calcium and inorganic phosphate were altered at doses of 500 and 1,000 mg/kg. However, no changes were observed at the dose of 250 mg/kg. With regards histopathological findings, cortical tubular basophilia of the kidney increased at the dose of 1,000 mg/kg, but not at doses of 250 and 500 mg/kg. No significant changes were observed in other organs at doses of 250, 500, and 1,000 mg/kg. Conclusions Based on the results, TSP is unclassified according to the Globally Harmonization System, with an LD50 value of over 2,000 mg/kg. The no observed effect level (NOEL) and no observed adverse effect level (NOAEL) were 250 and 500 mg/kg /day respectively and the target organ appears to be the kidney.
Journal of Food Hygiene and Safety | 2013
Dong-Seok Seo; Jong-Koo Kang; Mi-Hye Jeong; Min Kwon; Cheol-Beom Park
ABSTRACT - We evaluated the anti-diabetic effects of Isaria tenuipes in diabetes mellitus type 2. For the exper-iments, the diabetic animal model OLETF rats were divided to 4 groups: Isaria tenuipes was administered mixed withthe high fat diet 45% at dose levels of 0.0%, 0.1%, 1.0%, and 5.0% for 4 weeks. All animals have free access to waterand high fat diet 45%. The diabetic clinical markers, including clinical signs, body weight and food intake, organweights, blood glucose level, insulin level and HOMA-IR index, oral glucose tolerance test, GLUT4 mRNA and pro-tein were measured at a time. After administration for 4 weeks, the blood glucose levels, insulin levels and HOMA-IR index of test groups were decreased compared with control group in dose-dependent manner. The body weight anddiet consumptions were reduced in control group at 4 weeks. The treatments of Isaria tenuipes also showed highexpression of GLUT4 mRNA and protein in the muscle of OLETF rats. The results suggest that Isaria tenuipes hasanti-hyperglycemic effect attenuating blood glucose in the animal model of type 2 diabetes and might be useful as afunctional diet for human diabetic diseases.Key words: Isaria tenuipes, diabetes mellitus, OLETF rats, glucose, insulin, GLUT4
The Korean Journal of Pesticide Science | 2013
Min Kwon; Tae-Ku Kang; Chang-Kook Chung; Cheol-Beom Park
한국농약과학회 학술발표대회 논문집 | 2014
Sung-Sup Shin; Won-Chan Kim; Bo-Seung Lee; Yong-Seok Kim; Cheol-Ki Baek; Chang-kook Chung; Min Kwon
The Korean Journal of Pesticide Science | 2014
Jae-Gu Cho; Mee-Seon Kim; Hyun-Jung Choi; Min Kwon; Tae-Gu Kang; Chang-Kook Chung; Kyun Kim; Seung-Min Oh; Cheol-Beom Park
한국실험동물학회 학술발표대회 논문집 | 2012
Yong-Hoon Lee; D. Kim; Sun-Hee Park; Hye-Yeong Lee; Mi-Young Lee; Beom Seok Han; Min Kwon; Woo Chan Sohn; Ji Hyeon Seok; Jong Kwon Lee; Jayoung Jeong; Jin Seok Kang; Jong-Koo Kang
The Korean Journal of Pesticide Science | 2011
Suk-Jin Koo; Min Kwon; Cheol-Beom Park
THE KOREAN JOURNAL OF PESTICIDE SCIENCE | 2011
Dong-Seok Seo; Min Kwon; Ha-Jung Sung; Cheol-Beom Park
한국실험동물학회 학술발표대회 논문집 | 2010
Min Kwon; Dong-Seok Seo; Cheol-Beom Park
환경독성보건학회 심포지엄 및 학술대회 | 2009
Dong-Seok Seo; Min Kwon; Dong-Hyouk Jang; Nark-Won Sung; Cheol-Beom Park