Min Woo Lee
Hanyang University
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Publication
Featured researches published by Min Woo Lee.
Circulation-cardiovascular Interventions | 2014
Sunki Lee; Min Woo Lee; Han Saem Cho; Joon Woo Song; Hyeong Soo Nam; Kyeongsoon Park; Wang Yuhl Oh; Hongki Yoo; Jin Won Kim
Background—Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was to assess lipid-rich inflamed plaques in vivo using fully integrated high-speed optical coherence tomography (OCT)/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration–approved indocyanine green (ICG). Methods and Results—An integrated high-speed intravascular OCT/NIRF imaging catheter and a dual-modal OCT/NIRF system were constructed based on a clinical OCT platform. For imaging lipid-rich inflamed plaques, the Food and Drug Administration–approved NIRF-emitting ICG (2.25 mg/kg) or saline was injected intravenously into rabbit models with experimental atheromata induced by balloon injury and 12- to 14-week high-cholesterol diets. Twenty minutes after injection, in vivo OCT/NIRF imaging of the infrarenal aorta and iliac arteries was acquired only under contrast flushing through catheter (pullback speed up to ⩽20 mm/s). NIRF signals were strongly detected in the OCT-visualized atheromata of the ICG-injected rabbits. The in vivo NIRF target-to-background ratio was significantly larger in the ICG-injected rabbits than in the saline-injected controls (P<0.01). Ex vivo peak plaque target-to-background ratios were significantly higher in ICG-injected rabbits than in controls (P<0.01) on fluorescence reflectance imaging, which correlated well with the in vivo target-to-background ratios (P<0.01; r=0.85) without significant bias (0.41). Cellular ICG uptake, correlative fluorescence microscopy, and histopathology also corroborated the in vivo imaging findings. Conclusions—Integrated OCT/NIRF structural/molecular imaging with a Food and Drug Administration –approved ICG accurately identified lipid-rich inflamed atheromata in coronary-sized vessels. This highly translatable dual-modal imaging approach could enhance our capabilities to detect high-risk coronary plaques.
Scientific Reports | 2016
Ji Bak Kim; Kyeongsoon Park; Jiheun Ryu; Jae Joong Lee; Min Woo Lee; Han Saem Cho; Hyeong Soo Nam; Ok Kyu Park; Joon Woo Song; Tae Shik Kim; Dae-Gab Gweon; Wang Yuhl Oh; Hongki Yoo; Jin Won Kim
Macrophages mediate atheroma expansion and disruption, and denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone plaques. Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), and maleimide-polyethylene glycol-mannose as mannose receptor binding ligands to specifically target a subset of macrophages abundant in high-risk plaques. This probe showed high affinity to mannose receptors, low toxicity, and allowed the direct visualization of plaque macrophages in murine carotid atheroma. After the scale-up of the MMR-NIRF probe, the administration of the probe facilitated in vivo intravascular imaging of plaque inflammation in coronary-sized vessels of atheromatous rabbits using a custom-built dual-modal optical coherence tomography (OCT)-NIRF catheter-based imaging system. This novel imaging approach represents a potential imaging strategy enabling the identification of high-risk plaques in vivo and holds promise for future clinical implications.
Applied Optics | 2016
Dong-Ryoung Lee; Suin Jang; Min Woo Lee; Hongki Yoo
We propose a dual-detection confocal displacement sensor (DDCDS) with a compact fiber-based optical probe. This all-fiber-optic sensor probe is simple and robust, since it only requires simple alignment of a gradient refractive index lens and a double-clad fiber (DCF). The DDCDS is composed of two point detectors, one coupled to a single mode fiber and the other coupled to a multimode fiber, which are used to measure the light intensity from a core and an inner clad of a DCF, respectively. The ratio of the axial response curves, measured by the two detectors, can be used to obtain a linear relationship between the axial position of the object plane and the ratio of the intensity signals. We demonstrate the performance of the proposed method by measuring micromovement and fast vibration.
Scientific Reports | 2018
Min Woo Lee; Joon Woo Song; Woo Jae Kang; Hyeong Soo Nam; Tae Shik Kim; SunWon Kim; Wang-Yuhl Oh; Jin Won Kim; Hongki Yoo
Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an atherosclerotic rabbit artery in vivo. Especially, the autofluorescence lifetime of the endogenous tissue molecules can be used to characterize the biochemical composition; thus no exogenous contrast agent is required. Also, the physical properties of the imaging catheter and the imaging procedures are similar to those already used clinically, facilitating rapid translation into clinical use. This new intravascular imaging catheter can open up new opportunities for clinicians and researchers to investigate and diagnose coronary artery disease by simultaneously providing tissue microstructure and biochemical composition data in vivo without the use of exogenous contrast agent.
Jacc-cardiovascular Imaging | 2018
Jae Joong Lee; Min Woo Lee; Tae Shik Kim; Joon Woo Song; Hyeong Soo Nam; Wang Yuhl Oh; Hongki Yoo; Kyeongsoon Park; Jin Won Kim
Intraplaque hemorrhages (IPH) accelerate plaque destabilization via oxidative stress, free cholesterol secretion, macrophage accumulation, and necrotic core expansion. Macrophages in these hemoglobin-exposed segments differentiate into a distinct phenotype characterized by the expression of CD163
European Heart Journal | 2016
SunWon Kim; Min Woo Lee; Tae Shik Kim; Joon Woo Song; Hyeong Soo Nam; Han Saem Cho; Sun-Joo Jang; Jiheun Ryu; Dae-Gab Gweon; Seong Hwan Park; Kyeongsoon Park; Wang Yuhl Oh; Hongki Yoo; Jin Won Kim
Biomedical Engineering Letters | 2014
Jun Young Kim; Min Woo Lee; Hongki Yoo
Biomedical Optics Express | 2018
Hyeong Soo Nam; Woo Jae Kang; Min Woo Lee; Joon Woo Song; Jin Won Kim; Wang Yuhl Oh; Hongki Yoo
Circulation | 2014
SunWon Kim; Min Woo Lee; Han Saem Cho; Joon Woo Song; Sunki Lee; Kyeongsoon Park; Wang-Yuhl Oh; Hongki Yoo; Jin Won Kim
Archive | 2018
Hyeong Soo Nam; Woo Jae Kang; Min Woo Lee; Joon Woo Song; Jin Kim; Wang-Yuhl Oh; Hongki Yoo