Minoru Kubota
Kyoto University
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Featured researches published by Minoru Kubota.
Chemical & Pharmaceutical Bulletin | 2016
Masahiro Kobayashi; Hidetoshi Isawa; Junichi Sonehara; Minoru Kubota; Tetsuji Ozawa
A practical preparation of 4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 2 is described. O-Glycosylation of 4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one derivative 3 was facilitated by introduction of electron-withdrawing substituents, such as an acetyl group, at the N1-position of the pyrazole ring. 1-Acetyl-4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one 10 reacted with 2,3,4,6-tetra-O-acyl-α-D-glucopyranosyl bromide 5 in the presence of potassium carbonate in acetonitrile to provide the 1-acetyl-4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 11 in high yield. When 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide (5b) was used as a glycosyl donor, the resulting O-glycosylated product 11 was N1-deacetylated in the presence of potassium bicarbonate in methanol without unfavorable deprotection of the glycosyl moiety to provide 2 in excellent yield. The synthetic intermediate 2b of Remogliflozin etabonate (1b) was synthesized using this strategy.
Bulletin of the Chemical Society of Japan | 1980
Takakazu Yamamoto; Minoru Kubota; Akio Yamamoto
Bulletin of the Chemical Society of Japan | 1980
Takakazu Yamamoto; Yoshio Ehara; Minoru Kubota; Akio Yamamoto
Bulletin of the Chemical Society of Japan | 1978
Minoru Kubota; Akio Yamamoto
Bulletin of the Chemical Society of Japan | 1978
Takakazu Yamamoto; Minoru Kubota; Akira Miyashita; Akio Yamamoto
Bulletin of the Chemical Society of Japan | 1979
Minoru Kubota; Takakazu Yamamoto; Akio Yamamoto
Journal of the American Chemical Society | 1975
Haruaki Yajima; Hiroshi Ogawa; Minoru Kubota; Takayoshi Tobe; Masaki Fujimura; Kimio Henmi; Kanzi Torizuka; Hideki Adachi; Hiroo Imura; Tomohiko Taminato
Chemical & Pharmaceutical Bulletin | 1976
Hiroshi Ogawa; Minoru Kubota; Haruaki Yajima; Takayoshi Tobe; Masaki Fujimura; Kimio Henmi; Kanzi Torizuka; Hideki Adachi; Hiroo Imura; Tomohiko Taminato
Chemical & Pharmaceutical Bulletin | 2003
Takashi Yanagi; Ken Kikuchi; Hideki Takeuchi; Takehiro Ishikawa; Toshihiro Nishimura; Minoru Kubota; Iwao Yamamoto
Chemical & Pharmaceutical Bulletin | 1980
Minoru Kubota; Osamu Nagase; Hiro Amano; Hiroshi Takagi; Haruaki Yajima