Minoru Saiki

Treatment of high-risk peripheral T-cell lymphomas other than anaplastic large-cell lymphoma with a dose-intensified CHOP regimen followed by high-dose chemotherapy. A single institution study.

We investigated the efficacy of a dose-intensified double-CHOP regimen followed by high-dose chemotherapy with or without peripheral blood stem cell transplantation (PBSCT) in 11 patients with four types of peripheral T-cell lymphoma (PTCL). Three of the 4 patients with unspecified PTCL (PTCLu) achieved complete response (CR); 1 patient relapsed and 1 died of secondary leukemia after consolidation therapy. All angioimmunoblastic T-cell lymphoma (AILT) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients achieved CR; 5 of 6 have remained disease free for more than 3 years. The patient with hepatosplenic lymphoma did not achieve CR even after PBSCT and underwent allogenic bone marrow transplantation (allo-BMT). Thus, our regimen appears to be effective for high-risk AILT and SPTCL. However, allo-BMT should be considered for high-risk of PTCLu and hepatosplenic T-cell lymphoma.

Spontaneous clinical and cytogenetic remission of aplastic anemia in a patient with del(13q)

We describe the case of a 64-year-old Japanese man with pancytopenia. Bone marrow biopsy findings were consistent with aplastic anemia. The patient was treated by transfusions without immunosuppressive therapy. Chromosome analysis of bone marrow cells at 6 months after onset showed a 46,XY,del(13) (q14q22) karyotype. The pancytopenia resolved gradually over the next 5 years; chromosome analysis of bone marrow cells at that time yielded normal findings. To our knowledge, this is the first report of spontaneous hematologic and cytogenetic remission of aplastic anemia. These findings suggest that the abnormal clone with deletion of the long arm of chromosome 13 was not sufficient for clonal evolution in aplastic anemia in this case.

A case of therapy-related leukemia 7 years after the initiation of DAV therapy for malignant melanoma

We report a case of a 39-year-old Japanese man who was operated on for malignant melanoma (NM, stage II c) on his right leg. After its operation, adjuvant chemotherapy with dacarbazine, nimustine hydrochloride and vincristine sulfate was performed 8 times over a period of 2 years. Seven years after the initiation of the therapy, he developed purpurae on his legs, accompanied by pancytopenia. Skin biopsy was performed on the purpurae and a histopathological examination showed infiltration of leukemic cells in the dermis. Bone marrow biopsy was performed and the patient was diagnosed with acute myelocytic leukemia (megakaryocytic leukemia). This case was thought to be a case of therapyrelated leukemia. [Skin Cancer (Japan) 2008; 23: 93-97]