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Dive into the research topics where Miriam Furst is active.

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Featured researches published by Miriam Furst.


Journal of the Acoustical Society of America | 1985

Click lateralization is related to the β component of the dichotic brainstem auditory evoked potentials of human subjects

Miriam Furst; Robert A. Levine; Patricia M. McGaffigan

The changes in perception and in the binaural difference waveform (BD) for dichotic clicks with interaural time and level differences (ITDs and ILDs) are compared. Only beta, the first major peak of the BD, correlated with the perceptual measurements. Whenever beta is clearly present, the clicks are perceived as a unitary fused image. Whenever the clicks are perceived as not fused, beta is undetectable by our methods. The amplitude of beta remains nearly constant as the ITD is increased to about 1 ms, while the clicks position is perceived as moving from midline toward the leading ear. Over about the next 0.2 ms, beta becomes undetectable, as the image stops moving and loses its fused quality. As the ILD is increased, beta amplitude decreases gradually, while the image remains unitary and moves toward the unattenuated earphone. Thus beta becomes undetectable for ILDs of 30 to 35 dB, and the dichotic clicks become indistinguishable from monotic clicks for ILDs of 44 to 53 dB. The ITD and ILD matching curve for beta latency is similar to the ITD and ILD psychophysical matching curve for lateralization. These results suggest that beta is a physiological correlate of the categorical percept, binaural fusion, and is generated by a brainstem structure essential for the preception of click lateralization.


Ear and Hearing | 1995

Noise-induced Otoacoustic Emission Loss With or Without Hearing Loss

Joseph Attias; Miriam Furst; Vladimir Furman; Idit Reshef; Gil Horowitz; Ian Bresloff

The association between audiometric hearing thresholds and click-evoked otoacoustic emission (CEOAE) spectral properties was examined in 129 adult subjects with and without a noise-induced hearing loss (NIHL). Subjects were grouped according to their “beginning of hearing loss frequency” and their exposure to hazardous noise. Emissions were recorded with an ILOSS Otodynamic Analyzer (Version 2.9) used in the default mode. CEOAE levels decreased as the hearing threshold increased at each of the test frequencies (1, 2, 3, and 4 kHz). At frequencies where hearing thresholds were worse than 20 dB HL, CEOAEs could not be recorded. Thus as the “beginning of hearing loss frequency” decreased, the frequency range of the emissions became narrower. The hearing threshold for which emissions were not recorded varied significantly between subjects, such that even at frequencies where the hearing threshold was 0 dB HL emissions were not always observed. Noise-exposed, normal-hearing subjects had reduced overall CEOAE power with a narrow frequency range as compared with normal-hearing, nonexposed to noise subjects. For our test conditions, the presence of CEOAEs necessarily suggests hearing thresholds of 20 dB HL or less at the corresponding frequency. A lack of emissions does not necessarily indicate hearing thresholds beyond 20 dB HL.


Hearing Research | 1993

Effects of multiple sclerosis brainstem lesions on sound lateralization and brainstem auditory evoked potentials.

Robert A. Levine; J.C. Gardner; Barbara C. Fullerton; Steven M. Stufflebeam; E.W. Carlisle; Miriam Furst; Bruce R. Rosen; Nelson Y. S. Kiang

Magnetic resonance (MR) imaging, brainstem auditory evoked potentials (BAEPs), and tests of interaural time and level discrimination were performed on sixteen subjects with multiple sclerosis (MS). Objective criteria were used to define MR lesions. Of the eleven subjects in whom no pontine lesions were detected and the one subject who had pontine lesions that did not encroach upon the auditory pathways, all had normal BAEPs and interaural level discrimination, although a few had abnormal interaural time discrimination. Of four subjects with lesions involving the pontine auditory pathway, all had both abnormal BAEPs and abnormal interaural time discrimination; one also had abnormal interaural level discrimination. Analysis of the data suggest the following: waves I and II are generated peripheral to the middle of the ventral acoustic stria (VAS); wave III is generated ipsilaterally in the region of the rostral VAS, caudal superior olivary complex (SOC) and trapezoid body (TB); and waves V and L are generated contralaterally, rostral to the SOC-TB. The region of the ipsilateral rostral SOC-TB is implicated as part of the pathway involved in the generation of waves V and L. Interaural time discrimination of both high and low frequency stimuli were affected by all brainstem lesions that encroached on auditory pathways. A unilateral lesion in the region of the LL affected interaural time discrimination for low-frequency stimuli less severely than bilateral lesions of the LL or a unilateral lesion of the VAS. The only interaural level discrimination abnormality occurred for a subject with a unilateral lesion involving the entire rostral VAS. It appears that detailed analysis of lesion locations coupled with electrophysiological and psychophysical data holds promise for testing hypotheses concerning the function of various human auditory brainstem structures.


Hearing Research | 2000

Sound lateralization and interaural discrimination. Effects of brainstem infarcts and multiple sclerosis lesions.

Miriam Furst; Vered Aharonson; Robert A. Levine; Barbara C. Fullerton; Rina Tadmor; Hillel Pratt; Andrey Polyakov; Amos D. Korczyn

Subjects with brainstem lesions due to either an infarct or multiple sclerosis (MS) underwent two types of binaural testing (lateralization testing and interaural discrimination) for three types of sounds (clicks and high and low frequency narrow-band noise) with two kinds of interaural differences (level and time). Two major types of abnormalities were revealed in the lateralization performances: perception of all stimuli, regardless of interaural differences (time and/or level) in the center of the head (center-oriented), or lateralization of all stimuli to one side or the other of the head (side-oriented). Similar patterns of abnormal lateralization (center-oriented and side-oriented) occurred for MS and stroke patients. A subjects pattern of abnormal lateralization testing was the same regardless of the type of stimulus or type of interaural disparity. Lateralization testing was a more sensitive test than interaural discrimination testing for both types of subjects. Magnetic resonance image (MRI) scanning in three orthogonal planes of the brainstem was used to detect lesions. A semi-automated algorithm superimposed the auditory pathway onto each MRI section. Whenever a lesion overlapped the auditory pathway, some binaural performance was abnormal and vice versa. Given a lateralization test abnormality, whether the pattern was center-oriented or side-oriented was mainly determined by lesion site. Center-oriented performance was principally associated with caudal pontine lesions and side-oriented performance with lesions rostral to the superior olivary complex. For lesions restricted to the lateral lemniscus and/or inferior colliculus, whether unilateral or bilateral, just noticeable differences (JNDs) were nearly always abnormal, but for caudal pontine lesions JNDs could be normal or abnormal. MS subjects were more sensitive to interaural time delays than interaural level differences particularly for caudal pontine lesions, while stroke patients showed no differential sensitivity to the two kinds of interaural differences. These results suggest that neural processing of binaural stimuli is multilevel and begins with independent interaural time and level analyzers in the caudal pons.


Hearing Research | 2002

Mapping lateralization of click trains in younger and older populations

Harvey Babkoff; Chava Muchnik; Nofar Ben-David; Miriam Furst; Shmuel Even-Zohar; Minka Hildesheimer

The main purpose of this study was to describe and compare lateralization of earphone-presented stimuli in younger and older individuals. Lateralization functions, relating perceived location to either interaural time differences (ITDs) or interaural level differences (ILDs) were determined for 78 subjects, aged 21-88 years, who responded by pressing one of nine keys to indicate the perceived location of the stimulus. All subjects were healthy, without any history of hearing loss or ear surgery and within the normal pure tone audiometric range for their age group. Interaural pure tone and click thresholds did not differ by more than 5 dB across ears. The ILD lateralization functions, ranging from 10 dB favoring the left ear to 10 dB favoring the right ear were linear. In contrast, the ITD lateralization functions were S-shaped with a clear linear component ranging from 750 micros favoring one ear to 750 micros favoring the other ear and with an asymptote from 750 micros to 1 ms. The same general shape of the ITD and ILD lateralization functions was found at all ages, but the linear slope of the ITD lateralization function became shallower with age. The ability to discriminate midline-located click trains (ITD and ILD=0) from ITD-lateralized click trains deteriorated with age, while the comparable ability to discriminate ILD-lateralized click trains did not change significantly with age. The data support two general conclusions. First there seems to be an overall reduction in the range of ITD-based lateralization due to aging. Second, there is a greater reduction in sensitivity due to aging in changes from the perceived midline position (ITD and ILD=0) when ITD is manipulated than when ILD is manipulated.


Hearing Research | 1990

Prediction of binaural click lateralization by brainstem auditory evoked potentials

Miriam Furst; Sara Eyal; Amos D. Korczyn

A previous study by Furst et al. (1985) has shown that in healthy subjects brainstem responses evoked by binaural auditory stimuli with interaural time difference (ITD) and interaural level difference (ILD) include information about the integration of data received by both ears. A correlation was found between the first major peak of the binaural difference waveform and perception of click lateralization and fusion. We have now tested whether a similar correlation exists in patients with multiple sclerosis (MS). The ability to lateralize dichotic clicks was tested in MS patients with normal audiograms. Two kinds of psychoacoustical experiments were employed: (1) A matching experiment in which the subject was asked to match the perceived positions of two click trains, one of which consisted of dichotic clicks with ILD and the other dichotic clicks with ITD; and (2) A positional JND experiment in which the subject was asked to determine the difference in perceived position of two successive click trains. Two reference positions were tested, the head center and the side of the head near the ear, while the control was either on ITD or on ILD. According to the psychoacoustical performances, three groups of patients were identified. Group I consisted of patients who performed normally in all the psychoacoustical experiments. Group II patients were able to lateralize binaural clicks but performed abnormally in the matching experiment and in the position discrimination experiment when the control was on ITD and the reference position was the head center. The patients in Group II performed normally in the discrimination experiments when the control was on ILD, and when the control was on ITD but the reference position was the head side. Group III consisted of those who were not able to perform either one of the psychoacoustical experiments. They perceived the same binaural clicks in different positions in different times. Brainstem auditory potentials evoked by dichotic clicks with different ILDs and ITDs were measured in all the MS patients, and the corresponding binaural difference (BD) waveforms were calculated. Whenever beta, the first major peak of BD, was identified it was used to obtain a physiological matching curve. It was derived by matching an ILD on the basis of similar beta latencies. For every patient, in either Group I or II, the physiological matching curve was very similar to his psychoacoustical matching curve.


Journal of the Acoustical Society of America | 1992

Manifestations of intense noise stimulation on spontaneous otoacoustic emission and threshold microstructure: Experiment and model

Miriam Furst; Idit Reshef; Joseph Attias

Comparison between changes that occur simultaneously on spontaneous otoacoustic emissions (SOAEs) and on other cochlear origin phenomena can contribute to the understanding of cochlear micromechanical activity. The temporary changes that arise after short noise exposure are investigated in the following paper. The effects of noise exposure on the threshold microstructure near an SOAE and on the amplitude and frequency of the SOAE were measured. These experimental results indicate the following: (1) exposure to wideband noise for a short time causes a temporary reduction in the SOAE frequency and amplitude, and alters reversibly the threshold microstructure in the vicinity of the SOAE. The difference between the minimum and maximum in the threshold microstructure is reduced, and the frequency that yields the minimum threshold decreases; (2) the threshold at the SOAE frequency is most sensitive to noise exposure; (3) intense stimulation causes a relatively small increase, or even a decrease, in threshold at frequencies near the SOAE. The experimental results are interpreted in terms of a nonlinear transmission line model which includes nonlinear amplifiers. The effect of the noise exposure is modeled by reduction in the cochlear partition amplification term. Most of the experimental results are predicted by this model.


convention of electrical and electronics engineers in israel | 1995

Neural network based model for classification of music type

B. Matityaho; Miriam Furst

We can easily tell which type of music, like pop or classic, is played after listening to a few seconds of the music. But when looking at signal representation of the music, no clear difference can be seen. We propose a new approach to recognize the music type, using a multi-layer neural network as the decision making system. The presented model for classifying two types of music showed 100% success with a simple model based on a neural network.


Hearing Research | 1993

Binaural auditory processing in multiple sclerosis subjects

Robert A. Levine; J.C. Gardner; Steven M. Stufflebeam; Barbara C. Fullerton; E.W. Carlisle; Miriam Furst; Bruce R. Rosen; Nelson Y. S. Kiang

In order to relate human auditory processing to physiological and anatomical experimental animal data, we have examined the interrelationships between behavioral, electrophysiological and anatomical data obtained from human subjects with focal brainstem lesions. Thirty-eight subjects with multiple sclerosis were studied with tests of interaural time and level discrimination (just noticeable differences or jnds), brainstem auditory evoked potentials and magnetic resonance (MR) imaging. Interaural testing used two types of stimuli, high-pass (> 4000 Hz) and low-pass (< 1000 Hz) noise bursts. Abnormal time jnds (Tjnd) were far more common than abnormal level jnds (70% vs 11%); especially for the high-pass (Hp) noise (70% abnormal vs 40% abnormal for low-pass (Lp) noise). The HpTjnd could be abnormal with no other abnormalities; however, whenever the BAEPs, LpTjnd and/or level jnds were abnormal HpTjnd was always abnormal. Abnormal wave III amplitude was associated with abnormalities in both time jnds, but abnormal wave III latency with only abnormal HpTjnds. Abnormal wave V amplitude, when unilateral, was associated with a major HpTjnd abnormality, and, when bilateral, with both HpTjnd and LpTjnd major abnormalities. Sixteen of the subjects had their MR scans obtained with a uniform protocol and could be analyzed with objective criteria. In all four subjects with lesions involving the pontine auditory pathway, the BAEPs and both time jnds were abnormal. Of the twelve subjects with no lesions involving the pontine auditory pathway, all had normal BAEPs and level jnds, ten had normal LpTjnds, but only five had normal HpTjnds. We conclude that interaural time discrimination is closely related to the BAEPs and is dependent upon the stimulus spectrum. Redundant encoding of low-frequency sounds in the discharge patterns of auditory neurons, may explain why the HpTjnd is a better indicator of neural desynchrony than the LpTjnd. Encroachment of MS lesions upon the pontine auditory pathway always is associated with abnormal BAEPs and abnormal interaural time discrimination but may have normal interaural level discrimination. Our data provide one of the most direct demonstrations in humans of relationships among auditory performance, evoked potentials and anatomy. We present a model showing that many of these interrelationships can be readily interpreted using ideas developed from work on animals, even though these relationships could not have been predicted with confidence beforehand. This work provides a clear advance in our understanding of human auditory processing and should serve as a basis for future studies.


IEEE Transactions on Biomedical Engineering | 1991

Optimal a posteriori time domain filter for average evoked potentials

Miriam Furst; Avi Blau

For evoked potentials measured with scalp electrodes, the common procedure to determine the signal is to average N repetitive measurements, allowing signal detection to be improved. An algorithm that estimates the signal autocorrelation from N measurements is proposed. The estimator is consistent and unbiased, and its variance tends to zero as O(N). Two filters that are applied to the average response are introduced. Both depend on the estimation of the signal and the noise autocorrelations. One is based on the assumption that the average response is a stationary process. For the second, coefficients are obtained by minimizing the mean squared error (MSE) of an optimal filter of a nonstationary process applied on a single sweep. When a small number of sweeps are averaged the stationary assumption is adequate, and the MSE of the stationary optimal filter is two to five times less than the MSE of the average response. When a large number of measurements are considered the error in estimating the autocorrelations decreases. In this case applying the optimal filter for a nonstationary process leads to a significant improvement in the signal estimation.<<ETX>>

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Oded Barzelay

Technion – Israel Institute of Technology

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