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Mirielle Braeken

Janssen Pharmaceutica

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Publication

Featured researches published by Mirielle Braeken.

Bioorganic & Medicinal Chemistry Letters | 2000

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

Ludo Edmond Josephine Kennis; François Paul Bischoff; Carolus Mertens; Christopher John Love; Frans A.F Van den Keybus; Serge Maria Aloysius Pieters; Mirielle Braeken; Anton A. H. P. Megens; Josée E. Leysen

The synthesis and biological activity of a series of benzofuro[3,2-c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the alpha 2-adrenoceptor, with high selectivity versus the alpha 1-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation.

Journal of Medicinal Chemistry | 2007

2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Ellen W. Baxter; Kelly A. Conway; Ludo Edmond Josephine Kennis; Francois Paul Bischoff; Marc Mercken; Hans De Winter; Charles H. Reynolds; Brett A. Tounge; Chi Luo; Malcolm K. Scott; Yifang Huang; Mirielle Braeken; Serge Maria Aloysius Pieters; Didier Jean-Claude Berthelot; Stefan Masure; Wouter David Bruinzeel; Alfonzo D. Jordan; Michael H. Parker; Robert E. Boyd; Junya Qu; Richard S. Alexander; Douglas E. Brenneman; Allen B. Reitz

Archive | 1999

TRICYCLIC DELTA3-PIPERIDINES AS PHARMACEUTICALS

Ludo Edmond Josephine Kennis; Josephus Carolus Mertens; Mirielle Braeken

Archive | 2011

2-amino-puinazolin derivater anvendelige som inhibitorer af beta-sekretase (BACE)

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Charles H. Reynolds; Tina Morgan Ross; Brett A. Tounge; Mark Schulz; Winter Hans Louis Jos De; Serge Maria Aloysius Pieters; Allen B. Reitz

Archive | 2005

Nouveaux derives de 2-amino-quinazoline utiles en tant qu'inhibiteurs de la

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Charles H. Reynolds; Tina Morgan Ross; Brett A. Tounge; Mark Schulz; Winter Hans Louis Jos De; Serge Maria Aloysius Pieters; Allen B. Reitz

Archive | 2005

g(b)-secretase (bace)

Dieder Jean-Claude Berthelot; Francois Paul Bishoff; Mirielle Braeken; Winter Hans Louis Jos De; Marc Mercken; Serge Maria Aloysius Pieters

Archive | 2005

Derivatives of 2-amino-quinazolin used as inhibitors b-secretase (BACE).

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Charles H. Reynolds; Tina Morgan Ross; Brett A. Tounge; Mark Schulz; Winter Hans Louis Jos De; Serge Maria Aloysius Pieters; Allen B. Reitz

Archive | 2005

Als beta-sekretase (bace)-hemmer nützliche 2-amino-chinazolinderivate As beta-secretase (BACE) inhibitors useful 2-amino-quinazoline derivatives

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Winter Hans Louis Jos De; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Serge Maria Aloysius Pieters; Allen B. Reitz; Charles H. Reynolds; Tina Morgan Ross; Mark Schulz; Brett A. Tounge

Archive | 2005

Derivatives of 2-amino-quinazoline used as inhibitors of beta-secretase (BACE).

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Charles H. Reynolds; Tina Morgan Ross; Brett A. Tounge; Mark Schulz; Winter Hans Louis Jos De; Serge Maria Aloysius Pieters; Allen B. Reitz

Archive | 2005

inhibitors as beta-secretase (BACE) useful 2-amino-quinazoline derivatives

Ellen W. Baxter; Francois Paul Bischoff; Robert E. Boyd; Mirielle Braeken; Steven J. Coats; Yifang Huang; Alfonzo D. Jordan; Chi Luo; Marc Mercken; Charles H. Reynolds; Tina Morgan Ross; Brett A. Tounge; Mark Schulz; Winter Hans Louis Jos De; Serge Maria Aloysius Pieters; Allen B. Reitz

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Collaboration

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Serge Maria Aloysius Pieters

Janssen Pharmaceutica

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Alfonzo D. Jordan

Villanova University

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Allen B. Reitz

Fox Chase Cancer Center

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Charles H. Reynolds

University of Texas at Austin

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Tina Morgan Ross

West Chester University of Pennsylvania

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Carolus Mertens

Janssen Pharmaceutica

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Ludo Edmond Josephine Kennis

Janssen Pharmaceutica

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Anton A. H. P. Megens

Janssen Pharmaceutica

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Christopher John Love

Janssen Pharmaceutica

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Didier Jean-Claude Berthelot

Janssen Pharmaceutica

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