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Dive into the research topics where Miroslav D. Dramićanin is active.

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Featured researches published by Miroslav D. Dramićanin.


Biomaterials | 2011

In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes

Zoran Marković; Ljubica Harhaji-Trajkovic; Biljana Todorovic-Markovic; Dejan P. Kepić; Katarina Arsikin; Svetlana P. Jovanović; Aleksandar Pantovic; Miroslav D. Dramićanin; Vladimir Trajkovic

The present study compared the photothermal anticancer activity of near-infrared (NIR)-excited graphene nanoparticles and carbon nanotubes (CNT). Despite lower NIR-absorbing capacity, suspension of polyvinylpyrrolidone-coated graphene sheets exposed to NIR radiation (808 nm, 2 W/cm(2)) generated more heat than DNA or sodium dodecylbenzenesulfonate-solubilized single-wall CNT under the same conditions. Accordingly, graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro. The superior photothermal sensitivity of graphene sheets could be largely explained by their better dispersivity, which has been supported by a simple calculation taking into account thermodynamic, optical and geometrical properties of the two type of carbon nanoparticles. The mechanisms of graphene-mediated photothermal killing of cancer cells apparently involved oxidative stress and mitochondrial membrane depolarization resulting in mixed apoptotic and necrotic cell death characterized by caspase activation/DNA fragmentation and cell membrane damage, respectively.


Biomaterials | 2012

Graphene quantum dots as autophagy-inducing photodynamic agents

Zoran Marković; Biljana Ristic; Katarina Arsikin; Djordje Klisic; Ljubica Harhaji-Trajkovic; Biljana Todorovic-Markovic; Dejan P. Kepić; Tamara Kravic-Stevovic; Svetlana P. Jovanović; Marina Milenković; Dušan D. Milivojević; Vladimir Bumbasirevic; Miroslav D. Dramićanin; Vladimir Trajkovic

The excellent photoluminescent properties of graphene quantum dots (GQD) makes them suitable candidates for biomedical applications, but their cytotoxicity has not been extensively studied. Here we show that electrochemically produced GQD irradiated with blue light (470 nm, 1W) generate reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress. The cell death induced by photoexcited GQD displayed morphological and/or biochemical characteristics of both apoptosis (phosphatidylserine externalization, caspase activation, DNA fragmentation) and autophagy (formation of autophagic vesicles, LC3-I/LC3-II conversion, degradation of autophagic target p62). Moreover, a genetic inactivation of autophagy-essential LC3B protein partly abrogated the photodynamic cytotoxicity of GQD. These data indicate potential usefulness of GQD in photodynamic therapy, but also raise concerns about their possible toxicity.


Scientific Reports | 2015

Multifunctional Eu3+- and Er3+/Yb3+-doped GdVO4 nanoparticles synthesized by reverse micelle method

Tamara V. Gavrilović; Dragana Jovanovic; Vesna Lojpur; Miroslav D. Dramićanin

Synthesis of Eu3+- and Er3+/Yb3+-doped GdVO4 nanoparticles in reverse micelles and their multifunctional luminescence properties are presented. Using cyclohexane, Triton X-100, and n-pentanol as the oil, surfactant, and co-surfactant, respectively, crystalline nanoparticles with ~4 nm diameter are prepared at low temperatures. The particle size assessed using transmission electron microscopy is similar to the crystallite size obtained from X-ray diffraction measurements, suggesting that each particle comprises a single crystallite. Eu3+-doped GdVO4 nanoparticles emit red light through downconversion upon UV excitation. Er3+/Yb3+-doped GdVO4 nanoparticles exhibit several functions; apart from the downconversion of UV radiation into visible green light, they act as upconvertors, transforming near-infrared excitation (980 nm) into visible green light. The ratio of green emissions from 2H11/2 → 2I15/2 and 4S3/2 → 4I15/2 transitions is temperature dependent and can be used for nanoscale temperature sensing with near-infrared excitation. The relative sensor sensitivity is 1.11%K−1, which is among the highest sensitivities recorded for upconversion-luminescence-based thermometers.


Food Chemistry | 2015

Fluorescence spectroscopy coupled with PARAFAC and PLS DA for characterization and classification of honey

Lea Lenhardt; Rasmus Bro; Ivana Zeković; Tatjana Dramićanin; Miroslav D. Dramićanin

Fluorescence spectroscopy coupled with parallel factor analysis (PARAFAC) and Partial least squares Discriminant Analysis (PLS DA) were used for characterization and classification of honey. Excitation emission spectra were obtained for 95 honey samples of different botanical origin (acacia, sunflower, linden, meadow, and fake honey) by recording emission from 270 to 640 nm with excitation in the range of 240-500 nm. The number of fluorophores present in honey, excitation and emission spectra of each fluorophore, and their relative concentration are determined using a six-component PARAFAC model. Emissions from phenolic compounds and Maillard reaction products exhibited the largest difference among classes of honey of different botanical origin. The PLS DA classification model, constructed from PARAFAC model scores, detected fake honey samples with 100% sensitivity and specificity. Honey samples were also classified using PLS DA with errors of 0.5% for linden, 10% for acacia, and about 20% for both sunflower and meadow mix.


Journal of Applied Physics | 2015

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Blanca del Rosal; Alberto Pérez-Delgado; Małgorzata Misiak; Artur Bednarkiewicz; Alexander S. Vanetsev; Yurii V. Orlovskii; Dragana Jovanovic; Miroslav D. Dramićanin; Uéslen Rocha; K. Upendra Kumar; C. Jacinto; Elizabeth Navarro; Emma Martín Rodríguez; Marco Pedroni; Adolfo Speghini; G.A. Hirata; I.R. Martín; Daniel Jaque

The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF3:Nd3+, SrF2:Nd3+, NaGdF4: Nd3+, NaYF4: Nd3+, KYF4: Nd3+, GdVO4: Nd3+, and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a “universal” optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymium-doped nanoparticle to be preferentially used in each case.


Biomaterials | 2009

The protection of cells from nitric oxide-mediated apoptotic death by mechanochemically synthesized fullerene (C60) nanoparticles

Maja Misirkic; Biljana Todorovic-Markovic; Ljubica Vucicevic; Kristina Janjetovic; Vukoman Jokanovic; Miroslav D. Dramićanin; Zoran Marković; Vladimir Trajkovic

The influence of fullerene (C(60)) nanoparticles on the cytotoxicity of a highly reactive free radical nitric oxide (NO) was investigated. Fullerene nanoparticles were prepared by mechanochemically assisted complexation with anionic surfactant sodium dodecyl sulfate, macrocyclic oligosaccharide gamma-cyclodextrin or the copolymer ethylene vinyl acetate-ethylene vinyl versatate. C(60) nanoparticles were characterized by UV-vis and atomic force microscopy. While readily internalized by mouse L929 fibroblasts, C(60) nanoparticles were not cytotoxic. Moreover, they partially protected L929 cells from the cytotoxic effect of NO-releasing compounds sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitrosoglutathione (GSNO) and 3-morpholino-sydnonimine (SIN-1). C(60) nanoparticles reduced SNP-induced apoptotic cell death by preventing mitochondrial depolarization, caspase activation, cell membrane phosphatidylserine exposure and DNA fragmentation. The protective action of C(60) nanoparticles was not exerted via direct interaction with NO, but through neutralization of mitochondria-produced superoxide radical in NO-treated cells, as demonstrated by using different redox-sensitive reporter fluorochromes. These data suggest that C(60) complexes with appropriate host molecules might be plausible candidates for preventing NO-mediated cell injury in inflammatory/autoimmune disorders.


ACS Applied Materials & Interfaces | 2015

Modification of Structural and Luminescence Properties of Graphene Quantum Dots by Gamma Irradiation and Their Application in a Photodynamic Therapy

Svetlana P. Jovanović; Zois Syrgiannis; Zoran Marković; Aurelio Bonasera; Dejan P. Kepić; Milica D. Budimir; Dušan D. Milivojević; Vuk D. Spasojević; Miroslav D. Dramićanin; Vladimir B. Pavlović; Biljana Markovic

Herein, the ability of gamma irradiation to enhance the photoluminescence properties of graphene quantum dots (GQDs) was investigated. Different doses of γ-irradiation were used on GQDs to examine the way in which their structure and optical properties can be affected. The photoluminescence quantum yield was increased six times for the GQDs irradiated with high doses compared to the nonirradiated material. Both photoluminescence lifetime and values of optical band gap were increased with the dose of applied gamma irradiation. In addition, the exploitation of the gamma-irradiated GQDs as photosensitizers was examined by monitoring the production of singlet oxygen under UV illumination. The main outcome was that the GQDs irradiated at lower doses act as better photoproducers than the ones irradiated at higher doses. These results corroborate that the structural changes caused by gamma irradiation have a direct impact on GQD ability to produce singlet oxygen and their photostability under prolonged UV illumination. This makes low-dose irradiated GQDs promising candidates for photodynamic therapy.


Nanotechnology | 2014

Self-referenced luminescence thermometry with Sm3+ doped TiO2 nanoparticles

Miroslav D. Dramićanin; Željka Antić; Sanja Ćulubrk; Scott P. Ahrenkiel; Jovan M. Nedeljković

The performance of Sm(3+) doped TiO2 nanoparticles for luminescence temperature sensing was tested over a temperature range from room to 110 °C. The Sm(3+) ions were incorporated into TiO2 nanocrystals using hydrolytic sol-gel route. Microstructural characterization of the obtained material was performed using transmission electron microscopy and x-ray diffraction measurements. Luminescence emission spectra of Sm(3+) doped TiO2 nanoparticles consists of two distinct spectral regions: the high energy region associated with the trap emission of the TiO2 host, and the low energy region with well-resolved emission peaks of the Sm(3+) ions. The ratio between Sm(3+) emission and TiO2 trap emission shows strong temperature dependence, and is tested for temperature sensing. The relative sensor sensitivity was found to be higher than 1% °C(-1) over given temperature range with the maximum value of 10.54% °C(-1) at 57.5 °C. Lifetime data derived from the Sm(3+) emission decay revealed that time-resolved measurements provide comparable quality of temperature sensing as corresponding ratiometric measurements, with a maximum relative sensitivity of 10.14% °C(-1) at 66.5 °C.


ACS Nano | 2014

Large graphene quantum dots alleviate immune-mediated liver damage.

Vladislav Volarevic; Verica Paunovic; Zoran Marković; Bojana Simovic Markovic; Maja Misirkic-Marjanovic; Biljana Todorovic-Markovic; Sanja Bojic; Ljubica Vucicevic; Svetlana P. Jovanović; Nebojsa Arsenijevic; Ivanka Holclajtner-Antunović; M. Milosavljević; Miroslav D. Dramićanin; Tamara Kravic-Stevovic; Darko Ciric; Miodrag L. Lukic; Vladimir Trajkovic

We investigated the effect of large (40 nm) graphene quantum dots (GQDs) in concanavalin A (Con A; 12 mg/kg i.v.)-induced mouse hepatitis, a T cell-mediated liver injury resembling fulminant hepatitis in humans. Intravenously injected GQDs (50 mg/kg) accumulated in liver and reduced Con A-mediated liver damage, as demonstrated by histopathological analysis and a decrease in liver lipid peroxidation and serum levels of liver transaminases. The cleavage of apoptotic markers caspase-3/PARP and mRNA levels of proapoptotic mediators Puma, Noxa, Bax, Bak1, Bim, Apaf1, and p21, as well as LC3-I conversion to autophagosome-associated LC3-II and expression of autophagy-related (Atg) genes Atg4b, Atg7, Atg12, and beclin-1, were attenuated by GQDs, indicating a decrease in both apoptosis and autophagy in the liver tissue. This was associated with the reduced liver infiltration of immune cells, particularly the T cells producing proinflammatory cytokine IFN-γ, and a decrease in IFN-γ serum levels. In the spleen of GQD-exposed mice, mRNA expression of IFN-γ and its transcription factor T-bet was reduced, while that of the IL-33 ligand ST2 was increased. The hepatoprotective effect of GQDs was less pronounced in ST2-deficient mice, indicating that it might depend on ST2 upregulation. In vitro, GQDs inhibited splenocyte IFN-γ production, reduced the activation of extracellular signal-regulated kinase in macrophage and T cell lines, inhibited macrophage production of the free radical nitric oxide, and reduced its cytotoxicity toward hepatocyte cell line HepG2. Therefore, GQDs alleviate immune-mediated fulminant hepatitis by interfering with T cell and macrophage activation and possibly by exerting a direct hepatoprotective effect.


Applied Optics | 2013

Temperature dependence of emission and lifetime in Eu 3+ - and Dy 3+ -doped GdVO 4

Marko G. Nikolić; Dragana Jovanovic; Miroslav D. Dramićanin

Eu(3+)- and Dy(3+)-doped GdVO(4) samples synthesized by a high-temperature solid-state method are investigated by fluorescence spectroscopy at 298-750 K. They demonstrate potential for development as thermographic phosphors because the experimental and theoretical temperature dependence of the intensity ratio of the two lines agrees well. Experimental lifetime measurements recorded at 10-750 K were fitted using three theoretical models: multiphonon relaxation, temperature quenching through the charge transfer (CT) region, and our modified CT model (TDCT), which considers the temperature dependence of CT energy. The TDCT model yields the best results with good agreement between experimental and fitted lifetime data.

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