Miroslav Novotný

Association between ‐174 G/C polymorphism of interleukin‐6 gene and alcoholism

Objectives: IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of the G/C -174 polymorphism of the IL-6 gene on disposition to alcoholism. Methods: We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. Results: The significant difference in G allele frequency between alcoholic group (0.52) and control group (0.59) was found (P < 0.03). Conclusion: To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between the IL-6 gene and alcoholism is discussed.

Resistance of Trust Management Systems Against Malicious Collectives

Malicious peers in Peer-to-peer networks can develop sophisticated strategies to bypass existing security mechanisms. The effectiveness of contemporary trust management systems is usually tested only against simple malicious strategies. In this paper, we propose a simulation framework for evaluation of resistance of trust management systems against different malicious strategies. We present results of five TMS that represent main contemporary approaches; the results indicate that most of the traditional trust managements are vulnerable to sophisticated malicious strategies.