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Misako Kimura

Osaka University

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Publication

Featured researches published by Misako Kimura.

Nucleosides, Nucleotides & Nucleic Acids | 1992

Studies on griseolic acid derivatives. X: Synthesis and phosphodiesterase inhibitory activity of 2-substituted derivatives of griseolic acid

Masakatsu Kaneko; Misako Kimura; Yoshinobu Murofushi; Takashi Yasumoto; Yasuteru Iijima; Mitsuo Yamazaki

Abstract Griseolic acid derivatives which were modified at the 2-and/or 6-positions were first synthesized from griseolic acid by a ring opening—reclosure reaction of the adenine ring. Among these derivatives, the 2-amino-6-deamino-6-hydroxyl (guanine) derivative showed 3.3 and 45 times stronger inhibitory activity against cAMP and cGMP PDE, respectively, than those of griseolic acid. Structure-activity relationships among these derivatives are also discussed.

Archive | 1986

Griseolic acid derivatives, their preparation and their use

Masakatsu Kaneko; Yoshinobu Murofushi; Misako Kimura; Mitsuo Yamazaki; Yasuteru Iijima

Archive | 1986

Process for preparing griseolic acid derivatives

Masakatsu Kaneko; Misako Kimura; Yoshinobu Murofushi

Archive | 1984

Griseolic acid derivatives, and their use as enzyme inhibitors

Masakatsu Kaneko; Misako Kimura; Yoshinobu Murofushi; Mitsuo Yamazaki; Nobuyoshi Iwata

Chemical & Pharmaceutical Bulletin | 1977

Synthesis of D-Glucuronic Acid Derivatives of 5-Fluorouracil having O-Glycosidic Linkage

Masakatsu Kaneko; Hiroyuki Tanaka; Misako Kimura; Bunji Shimizu

Archive | 1995

Griseolic acid derivatives

Masakatsu Kaneko; Yoshinobu Murofushi; Misako Kimura; Mitsuo Yamazaki; Yasuteru Iijima

Chemical & Pharmaceutical Bulletin | 1977

Synthesis of N6- or 8-substituted 9-(beta-D-arabinofuranosyl)-adenines and their antiviral activities against herpes simplex and vaccinia viruses.

Masakatsu Kaneko; Misako Kimura; Takuzo Nishimura; Bunji Shimizu

Chemical & Pharmaceutical Bulletin | 1972

Synthesis and Properties of 8, 2'-Cyclothioguanosine and Related Compounds

Masakatsu Kaneko; Misako Kimura; Bunji Shimizu

Archive | 1995

Griseolic acid compounds and their use as a phosphodiesterase inhibitor

Masakatsu Kaneko; Yoshinobu Murofushi; Misako Kimura; Mitsuo Yamazaki; Yasuteru Iijima

Chemical & Pharmaceutical Bulletin | 1976

Synthesis of 7α-Methoxy-7-[2-(substituted thio) acetamido] cephalosporin Derivatives and Their Antibacterial Activities

Bunji Shimizu; Masakatsu Kaneko; Misako Kimura; Shinichi Sugawara

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Masakatsu Kaneko

Hokkaido University

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Yasuteru Iijima

University of Tokyo

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Bunji Shimizu

University of Tokyo

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Hiroyuki Tanaka

Kyoto University

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Junichi Yano

Osaka University

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Morio Ikehara

Osaka University

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Takuzo Nishimura

University of Tokyo

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