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Dive into the research topics where Misako Takezawa is active.

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Featured researches published by Misako Takezawa.


Biochemical and Biophysical Research Communications | 1987

Purification and characterization of Erythroid Differentiation Factor(EDF) isolated from human leukemia cell line THP-1

Yuzuru Eto; Tomoko Tsuji; Misako Takezawa; Satoshi Takano; Yasunori Yokogawa; Hiroshiro Shibai

We isolated a protein, from a cell line of human origin, which exhibits extensive differentiation inducing activity toward Friend leukemia cells. The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA). EDF is a homodimer of a molecular weight of 25,000, with an NH2-terminal sequence identical to that of the beta A-chain of porcine Inhibin. It was suggested that a single protein species is responsible for the activities of both EDF and FRP, a FSH releasing protein isolated from porcine ovarian follicular fluid.


Biotechnology and Bioengineering | 1988

Discovery of a human erythroid differentiation factor (EDF) and its large-scale production

Tomoko Tsuji; Yuzuru Eto; Satoshi Takano; Misako Takezawa; Yasunori Yokogawa; Hiroshiro Shibai


Agricultural and biological chemistry | 1985

A New Differentiation Inducer of Friend Leukemia Cells, Trichostatic Acid

Hajimu Morioka; Masaru Ishihara; Misako Takezawa; Kazuo Hirayama; Eiichiro Suzuki; Yasuo Komoda; Hiroshiro Shibai


Agricultural and biological chemistry | 1986

Differentiation of Friend Leukemia Cells Induced by β-, γ-, δ- and Aza-β-Mactam, and Thiaziadine Compounds

Hajimu Morioka; Misako Takezawa; Hiroshiro Shibai; Tadashi Okawara; Mitsuru Furukawa


Archive | 1986

Physiologically active polypeptide BUF-3

Yuzuru Eto; Tomoko Tsuji; Satoshi Takano; Misako Takezawa; Yasunori Yokogawa; Hiroshiro Shibai


Agricultural and biological chemistry | 1985

Production and Isolation of Cosmomycins A, B, C and D: New Differentiation Inducers of Friend Cell F5-5

Hajimu Morioka; Yuzuru Etoh; Issei Horino; Misako Takezawa; Toshihiko Ando; Kazuo Hirayama; Hideo Kano; Hiroshiro Shibai


Agricultural and biological chemistry | 1988

(+)-Trichostatin A, a Potent Differentiation Inducer of Friend Leukemia Cells

Hajimu Morioka; Masaru Ishihara; Misako Takezawa; Hiroshiro Shibai; Yasuo Komoda


Agricultural and biological chemistry | 1986

Differentiation Inducing Activity of Anthracycline Compounds in Friend Leukemia Cells

Tomoko Tsuji; Hajimu Morioka; Misako Takezawa; Toshihiko Ando; Asao Murai; Hiroshiro Shibai


Agricultural and biological chemistry | 1984

A new anthracycline antibiotic, cosmocarcin A.

Tomoko Tsuji; Misako Takezawa; Hajimu Morioka; Takao Kida; Issey Horino; Yuzuru Eto; Hiroshiro Shibai


Agricultural and biological chemistry | 1988

Disappearance of differentiation-induction of friend leukemia cells upon racemization of trichostatic acid

Hajimu Morioka; Masaru Ishihara; Misako Takezawa; Hiroshiro Shibai; Yasuo Komoda

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Yasuo Komoda

Tokyo Medical and Dental University

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