Mitali Chetia

Magnetically recoverable chitosan-stabilised copper–iron oxide nanocomposite material as an efficient heterogeneous catalyst for azide–alkyne cycloaddition reactions

Chitosan-stabilised copper–iron oxide nanocomposite material is found to be a very efficient recyclable/reusable heterogeneous catalyst for azide–alkyne cycloaddition reaction under mild conditions. The as-synthesized nanocomposite material is magnetically recoverable and reusable for a minimum of four cycles without significant loss in its catalytic activity. The catalytic system is found to be highly useful for the regioselective synthesis of a wide range of 1,2,3-triazoles from various azides and alkynes.

(DHQD)2PHAL ligand-accelerated Cu-catalyzed azide–alkyne cycloaddition reactions in water at room temperature

Herein, we have described, a ‘Click Chemistry’ protocol for the rapid synthesis of 1,2,3-triazoles in water. (DHQD)2PHAL has been found to be an excellent accelerating ligand for the copper(I)-catalyzed azide–alkyne cycloaddition reaction under air. The procedure is simple, efficient, environmentally-friendly and the products were isolated in excellent yields with high purity.

Facile route for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazole using copper nanoparticles supported on nanocellulose as recyclable heterogeneous catalyst

In this work, a green and efficient methodology has been developed for the synthesis of 1,2,3-triazoles by ‘copper nanoparticles supported on nanocellulose (CuNPs/NC)-catalyzed azide-alkyne cycloaddition reaction in glycerol, an environmentally benign solvent, with excellent yields. The present catalyst was characterized by TEM, XRD, SEM-EDX and FT-IR spectroscopy. The reusability of the prepared nanocatalyst was examined up to five times without significant loss of catalytic activity.Graphical Abstract:SYNOPSIS: A catalyst of copper nanoparticle supported on highly crystalline nanocellulose was prepared and was effectively used for the important regioselective synthesis of 1,4-disubstituted 1,2,3-triazole from the 1,3-dipolar cycloaddition of various azides and alkynes.