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Dive into the research topics where Mithra O. Gonzalez is active.

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Featured researches published by Mithra O. Gonzalez.


Ophthalmic Plastic and Reconstructive Surgery | 2017

Dilated Superior Ophthalmic Vein: Clinical and Radiographic Features of 113 Cases.

Christopher R. Adam; Carol L. Shields; Justin Gutman; H. Joon Kim; Brent Hayek; John W. Shore; Alexandra L. Braunstein; Flora Levin; Bryan J. Winn; Ivan Vrcek; Ronald Mancini; Craig Linden; Christina H. Choe; Mithra O. Gonzalez; David Altschul; Santiago Ortega-Gutierrez; Srinivasan Paramasivam; Johanna Fifi; Alejandro Berenstein; Vikram D. Durairaj; Roman Shinder

PURPOSE Dilated superior ophthalmic vein (SOV) is an uncommon radiographic finding. The authors review the presentation, etiology, radiography, and visual implications of 113 patients with dilated SOV. METHODS An observational case series and multicenter retrospective chart review were conducted. There were 113 patients with a dilated SOV. Outcome measures included patient demographics, clinical features, radiographic findings, diagnosis, and treatment, and treatment outcomes were assessed. RESULTS Cases included 75 women (66%) and 38 men (34%) with a mean age of 49 ± 24 years (range, 0.4-90 years). Diagnoses fell under 6 categories: vascular malformation (n = 92, 81%), venous thrombosis (n = 11, 10%), inflammatory (n = 6, 5%), traumatic hemorrhage (n = 2, 2%), lymphoproliferative (n = 1, 1%), and infectious (n = 1, 1%). Imaging modalities utilized included MRI (n = 98, 87%), digital subtraction angiography (n = 77, 68%), CT (n = 29, 26%), and ultrasonography (n = 4, 4%). Disease status at last follow up included no evidence of disease (n = 57, 50%), alive with persistent disease (n = 53, 47%), and expired from disease (n = 3, 3%). Treatment and management was tailored to the underlying disease process with a mean follow up of 18 months (range, 1 day to 180 months). Visual impairment observed at presentation and last follow up across all cases was 26% and 22%, respectively. CONCLUSION Dilated SOV is a rare radiographic finding resulting from a wide spectrum of etiologies with clinical implications ranging from benign to sight- and life-threatening. Dilated SOV is most often found with dural-cavernous fistula or carotid-cavernous fistula, orbital or facial arteriovenous malformation, and venous thrombosis. Recognition of this finding and management of the underlying condition is critical.


American Journal of Ophthalmology | 2014

Evaluation of Levator Function for Efficacy of Minimally Invasive and Standard Techniques for Involutional Ptosis

Stefano Ranno; Matteo Sacchi; Mithra O. Gonzalez; Meher T. Ravula; Paolo Nucci

PURPOSE To evaluate clinical and anatomic outcomes of surgery for involutional ptosis using standard-length or small incisions in relation to preoperative levator function. DESIGN Retrospective study. METHODS Sixty-three patients diagnosed with involutional ptosis who underwent surgical correction using a small or standard-length incision between November 2010 and December 2011 were reviewed; a single surgeon performed surgery using a small incision (8 to 10 mm) in 22 patients and a standard-length incision (20 to 22 mm) in 34 patients. All patients underwent standard preoperative ptosis evaluation with margin-to-reflex distance 1 and 2 measurements and levator function assessment. Patients were divided into 2 groups according to levator function (moderate: 5 to 10 mm; and good: >10 mm). Surgical success was evaluated based on the British Oculoplastic Surgery Society criteria. RESULTS Of 83 upper eyelids of 63 patients, surgery was performed using a small incision in 40 and a standard incision in 43. In patients with good levator function, surgical success was achieved with a small incision in 18 eyelids (94.7%) and a standard incision in 20 eyelids (95.2%; P = .91). In patients with moderate levator function, surgical success was achieved with a small incision in 14 eyelids (66.7%) and with a standard incision in 18 eyelids (81.8%; P = .04). CONCLUSIONS These findings indicate a similar surgical success rate in patients with good levator function, regardless of incision length. The surgical success rate in patients with moderate levator function was lower when using a small incision, perhaps because of decreased visualization and anatomic access.


Ophthalmic Plastic and Reconstructive Surgery | 2016

Dacryocystitis As the Initial Presentation of Invasive Fungal Sinusitis in Immunocompromised Children

Brett W. Davies; Mithra O. Gonzalez; Ryan C. Vaughn; Gregory C. Allen; Vikram D. Durairaj

Sino-orbital fungal infection is a rare, but life-threatening disease seen mainly in immunocompromised patients. While initial clinical impression may vary, dacryocystitis has rarely been described as the initial presenting sign. The authors present 2 pediatric cases of dacryocystitis as the initial sign of invasive fungal sinusitis. To their knowledge, this presenting sign has not been previously reported in the pediatric population. Management strategies and outcomes are discussed.


Ophthalmic Plastic and Reconstructive Surgery | 2015

Biodegradable Fixation of the Orbital Rim After Lateral Orbitotomy.

Brett W. Davies; Reid A. Mollman; Mithra O. Gonzalez; Eric M. Hink; Vikram D. Durairaj

Purpose:To describe authors’ experience with repair of the lateral orbital rim with poly-L/DL-lactic acid (PDLLA) biodegradable plates using ultrasonic pin fixation after lateral orbitotomy with bone flap. Methods:The authors retrospectively reviewed all patients who underwent a lateral orbitotomy with bone flap for biopsy of orbital tumors at their institution from January 2010 to May 2013. All patients underwent an orbitotomy by either a lateral eyelid crease incision or lateral canthotomy/cantholysis approach. A lateral bone flap was fashioned in the usual manner, extending from the frontozygomatic suture down the lateral rim for approximately 2 cm. The bone flap was repaired in each case with either a 6 or 7 hole PDLLA plate and secured with ultrasonic PDLLA pin fixation. Results:Twenty-four patients were identified who underwent a lateral orbitotomy with bone flap. Of these patients, 10 were repaired with PDLLA plates. The average age of the patients with PDLLA bone flap fixation was 55 years (range 5–85). The average follow-up time was 12.9 months (range 4–42). Indications included 4 lacrimal gland tumors, 4 intraconal tumors, and 2 lateral orbital tumors. Final diagnosis included lymphoma (3), squamous cell carcinoma (1), neuroblastoma (1), amyloid (1), fibrous tissue (1), sarcoidosis (1), cavernous hemangioma (1), and idiopathic orbital inflammation (1). Three patients had edema of the surrounding soft tissues after surgery, all but 1 resolved by postop month 3. There were 2 cases of transient temporal numbness that resolved by postop month 1. There were no cases of vision loss, extraocular motility deficit, infection, or need for removal of the implant before absorption. Conclusions:PDLLA biodegradable plates with ultrasonic pin placement provide a safe, effective means for lateral rim fixation after orbitotomy with bone flap.


Ophthalmic Plastic and Reconstructive Surgery | 2014

Conjunctivodacryocystorhinostomy and lacrimal sinus diversion via sinopsys surgical lacrimal stent: cadaveric proof of concept.

Mithra O. Gonzalez; Christopher Lee Oliver; Donald F. Schomer; Brian James Willoughby

Purpose: To determine the viability of lacrimal sinus diversion by using a novel Sinopsys Surgical Lacrimal Stent. Methods: Two disarticulated cadaveric heads were used in the laboratory. First, bilateral conjunctivodacryocystorhinostomies (CDCR) were performed by using a traditional Pyrex Jones tube and the Sinopsys Surgical Lacrimal Stent. The fluiditics were then evaluated by using contrast agent and fluroscopy. Subsequently, conjunctivoethmoidectomies (CE) and conjunctivomaxillectomies (CM) were performed by using the Sinopsys Surgical Lacrimal Stent, of which the fluiditics were also studied. Results: The conjunctivodacryocystorhinostomy (CDCR) placement experience of the Jones tube and the Sinopsys Surgical Lacrimal Stent were similar. The CDCR fluiditics as measured by using contrast agent and fluoroscopy were identical with each draining 0.5 mL over 5 to 10 seconds. Placement of the Sinopsys Surgical Lacrimal Stent in the 4 ethmoid (CE) and 4 maxillary (CM) sinuses was similar to the CDCR experience. Fluiditics of lacrimal sinus diversion were similar to CDCR with drainage of 0.5 mL over 5 seconds. Conclusions: The Sinopsys Surgical Lacrimal Stent has flow characteristics that are similar to a Pyrex Jones tube. Drainage in the nose via a CDCR procedure is similar to drainage in the ethmoid and maxillary sinuses via a CE and CM, respectively.


Ophthalmic Plastic and Reconstructive Surgery | 2013

American Society of Ophthalmic Plastic and Reconstructive Surgery fellowship survey: fellows selection criteria for training programs.

Jessica G. Shantha; Benjamin Shulman; Mithra O. Gonzalez; Eric M. Hink; Vikram D. Durairaj

Purpose: To investigate the characteristics that American Society of Ophthalmic Plastic and Reconstructive Surgery fellows seek in fellowship training programs. Methods: A 14-question anonymous SurveyMonkey survey was created for the 2011 to 2014 American Society of Ophthalmic Plastic and Reconstructive Surgery graduates. The survey evaluated fellow demographics, the interview process, and qualities fellows seek in fellowship training programs. A Likert scale was used to rate different qualities (1: not important, 9: very important), and summary statistics are reported as overall means and standard deviations. Analysis of variance comparisons were made between the different Ophthalmic Plastic and Reconstructive Surgery fellow graduate years, gender, and future practice goals. Results: In total, 87 surveys were e-mailed with 67 responses, a 77% response rate. The qualities with the highest mean were variety of surgical procedures (mean ± standard deviation: 8.6 ± 0.7), volume of procedures/surgeries (8.6 ± 0.7), personality of the program director (8.2 ± 1.3), and interview (7.7 ± 1.4). The characteristics that ranked the lowest in descending order were presence of a county hospital (5.1 ± 2.2), proximity to family (4.8 ± 2.7), didactics (4.7 ± 1.9), and benefits (4.4 ± 2.0). There was no statistically significant difference when comparing the groups according to gender and year of graduation. Fellows who want to pursue a career in academic medicine ranked academic fellowships higher in importance (8.0 ± 1.0) than those who wanted a career in private practice (5.3 ± 2.2). Conclusions: American Society of Ophthalmic Plastic and Reconstructive Surgery fellows place an emphasis on surgical experience, the program director’s personality, and the interview process when ranking fellowship training programs. This information is valuable for program directors to better recruit fellows.


Cornea | 2016

Keratoprosthesis in Ectodermal Dysplasia.

Rachel A. F. Wozniak; Mithra O. Gonzalez; James V. Aquavella

Purpose: To describe the complex surgical management and novel medical approach for a keratoprosthesis (KPro Boston type I) in a monocular, 73-year-old patient with ectodermal dysplasia and chronic, noninfectious corneal necrosis. Methods: Best-corrected visual acuity (BCVA) was measured with Snellen letters. Surgical intervention included an amniotic membrane graft, complete replacement of the KPro, conjunctival flap graft, corneal donor tissue grafts combined with inferior rectus muscle advancement, periosteal tissue graft, tarso-conjunctival flap construction, and symblepharolysis. Infliximab was used as a medical adjunctive therapy. Results: Initial KPro placement provided a BCVA of 20/25 and long-term stability. Subsequent chronic melting at the optic border necessitated numerous surgeries to prevent extrusion and failure. Ultimate fistulization was addressed with the formation of a surgical pocket. The addition of infliximab promoted ocular surface stability, and the patient has maintained a BCVA of 20/80. Conclusions: Ectodermal dysplasia can result in eyelid and corneal abnormalities, requiring a KPro for visual restoration. In the setting of chronic, sterile corneal melt, novel surgical approaches and the off-label use of infliximab allowed for visual rehabilitation.


Journal of Ocular Pharmacology and Therapeutics | 2012

Novel Formulation of Glycerin 1% Artificial Tears Extends Tear Film Break-Up Time Compared with Systane Lubricant Eye Drops

William Gensheimer; David M. Kleinman; Mithra O. Gonzalez; Deepak Sobti; Eugene Rex Cooper; Gerard Smits; Andrew Loxley; Mark Mitchnick; James V. Aquavella


Journal of Academic Ophthalmology | 2018

Evaluating Resident Training in Oculoplastic Surgery: A Case Series of 104 Eviscerations

Brittany Simmons; Anna Artymowicz; Mithra O. Gonzalez


Investigative Ophthalmology & Visual Science | 2009

Extension of Tear Film Break-Up by Novel Formulation of Glycerin 1%

W. Gensheimer; David M. Kleinman; Mithra O. Gonzalez; D. Sobti; A. Loxley; M. Mitchnick; James V. Aquavella

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Vikram D. Durairaj

University of Colorado Denver

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Brett W. Davies

University of Colorado Denver

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D. Sobti

University of Rochester

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Eric M. Hink

University of Colorado Denver

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