Mithun Bhowmick

DESIGN AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE USING COMBINATION OF HYDROPHILIC POLYMERS

Sustained release system is types of modified drug delivery system that can be used as an alternative to conventional system. Among different dosage forms, matrix tablets are widely accepted for oral sustained release Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin. Sustained release products are needed for metformin to prolong its duration of action and to improve patient compliances. They are capable of reducing the dose intake, minimize the blood level oscillation dose related adverse effect and cost thus improves the patient compliance in the therapeutic management of diabetes. The Metformin hydrochloride matrix Sustained release tablets were prepared using different hydrophilic polymers in various proportions as release retarding agent to prolong the drug release and to improve the patience compliance. The tablets were evaluated for various tests like hardness, friability, disintegration and in-vitro dissolution studies. Keywords : Matrix Tablets, Metformin hydrochloride, Hardness, Friability, Disintegration and in-vitro dissolution studies

Formulation Development and Evaluation of Polyherbal Hydrogel for Effective Treatment of Acne

Herb is a plant or part of a plant valued for its medicinal, aromatic, or savoury qualities. Herbs can be viewed as biosynthetic chemical laboratories, producing a number of chemical compounds. Herbal remedies or medicines consist of portions of plants or unpurified plant extracts containing several constituents, which often work together synergistically. Herbal formulations have more demanded in the market. One of the most common disorders found among youngsters usually 18 - 25 years of age is Acne. Acne vulgaris , which is a skin disorder of the pilosebaceous gland leads to the formation of inflammatory lesions, seborrhea, comedone, etc. The pus being formed in acne which triggers inflammation is due to Propionibacterium acnes. There is a remarkable demand of herbal formulations in the global market. So our aim and objective to develop safe and effective polyherbal formulation for effective management of acne.

DESIGN AND EVALUATION OF EXTENDED RELEASE CEFUROXIME AXETIL FLOATING TABLETS WITH IMPROVED GI ABSORPTION

Oral drug delivery system represents one of the frontier area of controlled drug delivery system. Floating drug delivery system belongs to oral controlled drug delivery system group, which is capable of floating in the stomach for prolong period of time. The objective of the present research work is to provide a gastroretentive system for sustained release of therapeutically active agent, cefuroxime axetil in upper part of gastro-intestinal tract in the form of floating tablet. Cefuroxime axetil, an oral prodrug shows a bioavailablity of 30% to 40% when taken on fasting and 5% to 60% whentaken after food. The cefuroxim axetil esterase can hydrolyze cefuroximeaxetil to the nonabsorbable cefuroxim in the gut lumen and is therefore, suspected as a possible cause of incomplete bioavailability. Which suggests an absorption mechanism through the mucosa with limited capacity. Cefuroxime axetil had saturation kinetics that could be overcome by slow release of drug from the formulation, by incorporating cefuroxime axetil in sustained drug delivery system. Keywords : Floating drug delivery system, Cefuroxime axetil, Gastro-intestinal tract

PHARMACOGNOSTIAL EVALUATION AND PHYTOCHEMICAL SCREENING OF THEVETIA PERUVIANA

Flowers of Plant Thevetia peruviana (Pers.) K. Schum.were reported to possess good medicinal value in traditional system of medicine, the present investigation deals with Macroscopic, Microscopic and preliminary phytochemical investigation of flowers of Thevetia peruviana which includes pharmacognostical parameters, physiochemical parameters like ash values, extractive values and moisture content. The total ash, acid insoluble ash, water‐soluble ash values and sulfated ash were observed to be 3.50%, 1.60%, 1.30% and 1.20% w/w respectively. Alcohol soluble, water‐soluble and Ether soluble extractive values of the flowers were observed to be 8.30%, 4.80%, and 3.70% respectively. Powdered flowers were also subjected to fluorescence analysis with different chemicals. Phytochemical investigation of powdered drug revealed the presence of Alkaloids, glycosides, tannins, phenolic compounds, proteins, essential oils, gums, mucilage and fixed oils. The main aim of the present investigation is to study the macro, microscopic and some other pharmacognostic characters and physicochemical standards of flowers of Thevetia peruviana Pers. which could be used to prepare a monograph for the proper identification of the plant. K e ywords: T hevetia peruviana , Phytochemical, Fluorescence analysis, Physical evaluation.

Design and evaluation of Matrix Transdermal therapeutic system of Repaglinide

http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2697-2705 ABSTRACT:The present study is an attempt to develop a Matrix type transdermal system capable of delivering the selected antidiabetic drug Repaglinide in the desired therapeutic concentration for prolong period. The principle of transdermal drug delivery systems is to deliver drug across epidermis to achieve systemic effect over a prolonged period of time. Because of these attributes, transdermal drug delivery systems offer many advantages such as reduced side effects, improved patient compliance, elimination of first-pass metabolism, and sustained drug delivery. Antidiabetic drug which is important for the treatment of hyperglycemic disorders. This category of anti-diabetic drugs is rapid and almost completely absorbed from the GIT following oral administration, but undergoes extensive first pass metabolism. Therefore, the peak plasma concentration occurs rapidly and after a single oral dose and bioavailability is 56%, the half-life of elimination is 1 hour in normal subject. Hence, it is required to design a drug delivery system which may deliver antidiabetic drug Repaglinide in controlled manner for a prolonged period to circumvent the drug related side effects. Considering all these problems associated with oral administration of anti-diabetic drug Repaglinide, attempt has been made to develop transdermal drug delivery system in order to achieve a better release pattern. ⇑ Corresponding author at: MithileshSahu, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India E-mail address: mithun211@gmail.com INTRODUCTION

Design and evaluation of a Sustained Release Gastroretentive Dosage form of Captopril

Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2535-2547 Abstract: Sustained drug delivery means not only prolonged duration of drug delivery but also implies predictability and reproducibility of drug release kinetics. In the present study gastroretentive dosage form (tablet) was selected as a method to design sustained release dosage forms because it is a rapidly expanding technology. The objective of the work was to design sustained release tablets of Captopril as gastroretentive drug delivery dosage form of a drug meant for management of treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. Formulation of gastroretentive drug delivery dosage forms are done based on optimization under factorial design of formula and classed formulation batches in which concentration of polymer HPMC of various grades (HPMC K15 M, HPMC K100M and HPMC K4M) varied with the ration of sodium bi carbonate and microcrystalline cellulose. Therefore, the Aim of the present work is design to formulate and evaluate gastroretentive dosage form (tablets) of Captopril for efficient sustained release after oral administration in case of congestive heart failure, kidney problems caused by diabetes.