Mithun Roy
Indian Institute of Science
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Publication
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Inorganic Chemistry | 2009
Sounik Saha; Ritankar Majumdar; Mithun Roy; Rajan R. Dighe; Akhil R. Chakravarty
Ternary iron(III) complexes [FeL(B)] (1-3) of a trianionic tetradentate phenolate-based ligand (L) and phenanthroline base (B), namely, 1,10-phenanthroline (phen, 1), dipyridoquinoxaline (dpq, 2), and dipyridophenazine (dppz, 3), have been prepared and structurally characterized and their DNA binding, cleavage, and photocytotoxic properties studied. The complexes with a FeN(3)O(3) core show the Fe(III)/Fe(II) redox couple near -0.6 V in DMF, a magnetic moment value of approximately 5.9 micro(B), and a binding propensity to both calf thymus DNA and bovine serum albumin (BSA) protein. They exhibit red-light-induced DNA cleavage activity following a metal-assisted photoredox pathway forming HO(*) radicals but do not show any photocleavage of BSA in UV-A light. Complex 3 displays photocytotoxicity in the human cervical cancer cell line (HeLa) and human keratinocyte cell line (HaCaT) with respective IC(50) values of 3.59 microM and 6.07 microM in visible light and 251 nM and 751 nM in UV-A light of 365 nm. No significant cytotoxicity is observed in the dark. The photoexposed HeLa cells, treated prior with complex 3, have shown marked changes in nuclear morphology as demonstrated by Hoechst 33258 nuclear stain. Generation of reactive oxygen species has been evidenced from the fluorescence enhancement of dichlorofluorescein upon treatment with 3 followed by photoexposure. Nuclear chromatin cleavage has been observed in acridine orange/ethidium bromide dual staining of treated HeLa cells and from alkaline single-cell gel electrophoresis. Caspase 3/7 activity in HeLa cells has been found to be upregulated by only 4 fold after photoirradiation, signifying the fact that cell death through a caspase 3/7 dependent pathway may not be solely operative.
Inorganic Chemistry | 2011
Tridib K. Goswami; Balabhadrapatruni V. S. K. Chakravarthi; Mithun Roy; Anjali A. Karande; Akhil R. Chakravarty
Organometallics | 2010
Basudev Maity; Mithun Roy; Bhabatosh Banik; Ritankar Majumdar; Rajan R. Dighe; Akhil R. Chakravarty
Organometallics | 2009
Basudev Maity; Mithun Roy; Sounik Saha; Akhil R. Chakravarty
Inorganic Chemistry | 2007
Mithun Roy; Biswarup Pathak; Ashis K. Patra; Eluvathingal D. Jemmis; Munirathinam Nethaji; Akhil R. Chakravarty
Organometallics | 2009
Tridib K. Goswami; Mithun Roy; Munirathinam Nethaji; Akhil R. Chakravarty
Inorganic Chemistry | 2007
Mithun Roy; Sounik Saha; Ashis K. Patra; Munirathinam Nethaji; Akhil R. Chakravarty
Inorganic Chemistry | 2011
Sounik Saha; Dibyendu Mallick; Ritankar Majumdar; Mithun Roy; Rajan R. Dighe; Eluvathingal D. Jemmis; Akhil R. Chakravarty
Organometallics | 2012
Tridib K. Goswami; Sudarshan Gadadhar; Mithun Roy; Munirathinam Nethaji; Anjali A. Karande; Akhil R. Chakravarty
Journal of Organometallic Chemistry | 2008
Basudev Maity; Mithun Roy; Akhil R. Chakravarty
Collaboration
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Balabhadrapatruni V. S. K. Chakravarthi
University of Alabama at Birmingham
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