Mitsuhiro Takashita

Elevation of IL‐6 in ATL Patient with a Pathological Fracture

Hypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61‐year‐old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased serum levels of Interleukin‐6 (IL‐6) and a parathyroid hormone‐related protein (PTHrP) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions.

Pes Anserinus Enthesopathy Caused by Hydroxyapatite

It is well known that hydroxyapatite is a useful biomaterial with biocompatibility and nontoxicity in the reconstructive field of orthopedic surgery.We report a case with suspected pes anserinus bursitis or enthesopathy caused by hydroxyapatite. A 56-year-old woman suffering from renal sarcoidosis with bone defect of the left medial tibial condyle underwent operation for hydroxyapatite 3 years ago. At this time, though the hydroxyapatite spilt and fell in the operation field, no symptoms were seen for 3 years.Because of recurring sharp pain in the same area, we thought that this pain was caused by hydroxyapatite, and we removed the hydroxyapatite, after which the sharp pain disappeared.Histologically, foreign body gaint cells around the hydroxyapatite particle were observed, but no inflammatory reaction and calcification were seen.

Ten Years Follow-up Findings in the Knee Joint with J-K Membrane

A total knee replacement was performed on a patient suffering from pain with rheumatoid arthritis. This knee had been done of arthroplasty using interposing chromicized fascia lata (J-K Membrane). Macroscopic and microscopic findings were studied. This paper reports these findings in the knee joint which had been passed for ten years with J-K membrane.