Mitsuru Shibukawa

Studies on AI-77s, microbial products with gastroprotective activity. Structures and the chemical nature of AI-77s

Abstract The structures and the chemical nature of a novel gastroprotective substance AI-77-B (1) and its analogues AI-77-C (2), D (3), F (4) and G (5), which are produced by Bacillus pumilus AI-77, are described. The structure of 1 was confirmed to be 6-[[1(S)-(3(S), 4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]amino]-4(S),5(S)-dihydroxy-6-oxo-3(S)-aminohexanoic acid by X-ray in combination with chemical studies and the structures of 2, 3, 4 and 5 were determined by chemical syntheses from 1 and spectral analyses.

(Studies on AI-77s, microbial products with pharmacological activity) structures and the chemical nature of AI-77s

Abstract The structures of a novel gastroprotective substance AI-77-B and its analogues AI-77-C, D, F and G, which are produced by Bacillus pumilus , are described. Five of the asymmetric centers of AI-77-B have S absolute stereochemistry confirmed by X-ray in combination with chemical studies.