Mitsutaka Okuda
Tohoku University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Mitsutaka Okuda.
British Journal of Haematology | 1993
Kazuyasu Endo; Hideo Harigae; Tadashi Nagai; Hiromi Fujie; Kuniaki Meguro; Norimichi Watanabe; Kazumichi Furuyama; Junichi Kameoka; Mitsutaka Okuda; Norio Hayashi; Masayuki Yamamoto; Keishi Abe
Summary We established two cell lines, YN‐1 and Y‐1K. from the peripheral blood of two chronic myelogenous leukaemia patients in blastic crisis. Characterization of the YN‐1 and Y‐1K cells revealed that these cells expressed erythroid lineage markers. However, there was a marked difference in the level of γ‐globin mRNA and haenioglobin in YN‐1 and Y‐1K cells. YN‐1 contained approximately 1–5% benzidine‐positive staining cells, whereas no benzidine‐positive cells were observed in Y‐1K cells. Haemoglobin production in YN‐1 cells was markedly increased with various chemical inducers of erythroid differentiation, but was not in Y‐1K cells. In contrast, Y‐1K cells expressed CD34 stem cell antigen and CD41 megakaryocyte‐specific antigen. These observations suggested that, although both cell lines were committed to the erythroid lineage. each cell line represented a distinct differentiation stage in the erythroid differentiation programme. Y‐1K seemed to correspond to an early stage of cells in erythroid lineage, whereas YN‐1 represented a more advanced stage in human erythropoiesis.
International Journal of Hematology | 2009
Hiroto Ohguchi; Tomohiro Sugawara; Izumi Ishikawa; Mitsutaka Okuda; Yasuo Tomiya; Joji Yamamoto; Yasushi Onishi; Minami Yamada; Kenichi Ishizawa; Junichi Kameoka; Hideo Harigae
Bortezomib is approved for the treatment of patients with relapsed or refractory multiple myeloma (MM), but only a few clinical studies for Japanese patients who were treated with bortezomib have been reported. We retrospectively analyzed 40 patients with relapsed or refractory MM who have received bortezomib at three collaborating centers in Miyagi prefecture in Japan. All the patients have been received bortezomib in combination with dexamethasone. Responses were determined using International Myeloma Working Group uniform response criteria. The overall response was observed in 30 patients (75%), including very good partial response in 8 patients (20%), and partial response in 22 patients (55%). The median time to disease progression was 8.7 months, and the median overall survival has not been reached. The factors affecting time to disease progression were International Staging System stage, serum β2-microglobulin level, and number of treatment cycles. The most common grade 3 and 4 adverse events were thrombocytopenia (50%), peripheral neuropathy (25%), leukopenia (25%), and herpes zoster infection (25%). Thus, bortezomib is well tolerated and effective for Japanese patients with relapsed or refractory MM. Our results suggest that serum β2-microglobulin level may be a marker of prognosis on bortezomib therapy for patients with relapsed or refractory MM although further studies are needed.
Internal Medicine | 2002
Mitsutaka Okuda; Jun Nomura; Hiroo Tateno; Junichi Kameoka; Takeshi Sasaki
British Journal of Haematology | 2008
Tomohiro Sugawara; Akiyoshi Sato; Tomoaki Shishido; Mitsutaka Okuda; Junichi Kameoka; Kuniaki Meguro; Kazuyasu Endo; Kaoru Yoshinaga
Tohoku Journal of Experimental Medicine | 1992
Kumiko Naito; Nobuaki Tamahashi; Tamihiko Chiba; Kyoko Kaneda; Mitsutaka Okuda; Kazuyasu Endo; Kaoru Yoshinaga; Tohru Takahashi
Acta Haematologica | 1992
Tomohiro Sugawara; Mitsutaka Okuda; Yuji Yamaguchi; Kazuyasu Endo; Kaoru Yoshinaga
The Japanese journal of clinical hematology | 2003
Horiuhi T; Jun Nomura; Mitsutaka Okuda; Ichinohasama R
Journal of Clinical Apheresis | 2006
Tsuneo Itoh; Masayoshi Minegishi; Yoshinori Kudo; Naoko Saito; Hiroyuki Takahashi; Akira Suzuki; Ayuko Narita; Yuko Sato; Junko Miura; Yaeko Inoue; Junichi Kameoka; Naruyoshi Suwabe; Masue Imaizumi; Mitsutaka Okuda; Shigeru Tsuchiya
The Japanese journal of clinical hematology | 1992
Hideo Harigae; Jun Nomura; Kazumichi Furuyama; Shishido T; Mitsutaka Okuda; Sato A; Sugawara T; Kazuyasu Endo; Yoshinaga K; Ichinohasama R
The Japanese journal of clinical hematology | 2006
Junichi Kameoka; Takahiro Horiuchi; Koichi Miyamura; Ikuo Miura; Mitsutaka Okuda; Jun Nomura; Makoto Hirokawa; Kenichi Sawada; Takeshi Sasaki