Miwa Aida
Toho University
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Publication
Featured researches published by Miwa Aida.
Japanese Journal of Cancer Research | 1999
Sachiko Okabe; Yumiko Ochiai; Miwa Aida; Keunchil Park; Seong-Jin Kim; Taro Nomura; Masami Suganuma; Hirota Fujiki
It is now well accepted that (–)‐epigallocatechin gallate (EGCG) inhibits carcinogenesis in the digestive tract in rodents. To understand the mechanisms of anticarcinogenesis, we first studied growth inhibition by EGCG in human stomach cancer cell lines established at Seoul National University(SNU cell lines). Inhibition by EGCG of [3H]thymidine incorporation into eight SNU celllines was examined, in relation to transforming growth factor‐β (TGF‐β) responsiveness. Various tea polyphenols derived from green tea and black tea induced growth inhibition and apoptosis of human stomach cancer cell line KATO III, and inhibition of tumor necrosis factor‐α (TNF‐α)release from the cells, in the order of (–)‐epicatechin gallate (ECG), EGCG, (–)‐epigallocatechin(EGC), teaflavins (TF) and (–)‐epicatechin (EC). In addition, we demonstrated that EGCG inhibited TNF‐α gene expression in KATO III cells, as well as okadaic acid‐induced AP‐1 and NF‐κB activation. The inhibitory potencies of EGCG for AP‐1 and NF‐κB binding to DNA were different between KATO III cells and mouse fibroblast cell line BALB/3T3. Thus, EGCG and other teapolyphenols may interact with various transcription factors, in addition to AP‐1 and NF‐κB, in nuclei of various cells, resulting in inhibition of TNF‐α gene expression and TNF‐α release.
Journal of The Chemical Society, Chemical Communications | 1992
Yoshio Hano; Miwa Aida; Taro Nomura; Shinichi Ueda
The structure of artonin I, an optically active Diels–Alder type adduct from Artocarpus heterophyllus, an Indonesian moraceous plant, was established utilizing the enzyme system of Morus alba cell cultures which specifically produce the natural Diels–Alder type adducts, as well as spectroscopic evidence.
Heterocycles | 1993
Miwa Aida; Kazuki Shinomiya; Yoshio Hano; Taro Nomura
Three new isoprenylated flavones, artonins J (1), K (2), and L (3) were isolated from the root bark of Artocarpus heterophyllus Lamk. (Moraceae). The structures of artonins J, K, and L were shown to be 1, 2, and 3, respectively, on the basis of spectroscopic data. The model compound (5) was derived from cycloartobiloxanthone (4) by treatment with alkaline solution
Phytochemistry | 1995
Kazuki Shinomiya; Miwa Aida; Yoshio Hano; Taro Nomura
A new natural Diels-Alder-type adduct, artonin X, along with two known Diels-Alder type adducts, were isolated from the bark of Artocarpus heterophyllus. The structure was elucidated by spectroscopic methods.
Heterocycles | 1998
Taro Nomura; Yoshio Hano; Miwa Aida
Biochemical Pharmacology | 1991
Gala Ramesh Reddy; Natsuo Ueda; Takahiko Hada; Arthur Commy Sackeyfio; Shozo Yamamoto; Yoshio Hano; Miwa Aida; Taro Nomura
Heterocycles | 1989
Taro Nomura; Yoshion Hano; Miwa Aida; Mikako Shiina; Takatoshi Kawai; Hiroshi Ohe; Kengo Kagei
Journal of Natural Products | 1990
Yoshio Hano; Miwa Aida; Taro Nomura
Heterocycles | 1995
Miwa Aida; Yoshio Hano; Taro Nomura
Heterocycles | 1997
Miwa Aida; Norihisa Yamaguchi; Yoshio Hano; Taro Nomura