Miwa Miyoshi

Non‐SCN5A Related Brugada Syndromes: Verification of Normal Splicing and Trafficking of SCN5A Without Exonic Mutations

Recently, it has been reported that under 20% of Brugada syndrome cases are linked to SCN5A mutations. The purpose of this study was to clarify whether abnormalities other than exonic mutations, such as splicing disorders, decreased mRNA expression levels, or membrane transport abnormalities of SCN5A, play a role in the pathogenesis of Brugada syndrome.

Bisoprolol Transdermal Patch Is Effective for the Treatment of AF Tachycardia

Atrial fibrillation (AF) is an irregular and often rapid heart rate that can increase the risk of stroke, heart failure, and other heart-related complications. Its incidence increases with age and the presence of concomitant heart disease. We present the cases of a 93-year-old woman, an 82-year-old man, and an 87-year-old woman who developed AF tachycardia. This report highlights the use of a bisoprolol transdermal patch to treat AF tachycardia in 3 adult elderly patients. In this paper, we report an initial treatment strategy using a bisoprolol transdermal patch and show heart rate trends for 24 hours.

Ablation of Idiopathic Ventricular Tachycardia with a Left Bundle-Branch Block Morphology Originating from the Pulmonary Artery

We successfully performed radiofrequency catheter ablation (RFCA) in 2 cases involving patients with idiopathic ventricular tachycardias (VTs) and premature ventricular contractions (PVCs) originating from the pulmonary artery (PA). The QRS morphology of the VTs and PVCs in the two cases exhibited a left bundle‐branch block (LBBB) morphology with an inferior axis. Activation and pace mappings were performed in the right ventricular outflow tract (RVOT) and above the pulmonary valve to determine the origin of the VTs and PVCs. In both cases, the earliest ventricular activation was recorded in the PA above the pulmonary valve. Applications of radiofrequency current at those sites in the PA resulted in the elimination and noninducibility of the VT and PVC. During the follow‐up, the VT or PVC did not recur without any antiarrhythmic drug administration.