Miyuki Fujieda
Nagoya University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Miyuki Fujieda.
Japanese Journal of Cancer Research | 2002
Mihoko Kato; Takashi Nagaya; Miyuki Fujieda; Kiyoshi Saito; Jun Yoshida; Hisao Seo
Peroxisome proliferator‐activated receptor y (PPARγ) belongs to a superfamily of thyroid/steroid hormone receptors and regulates transcription of their target genes in a ligand‐dependent manner. Recently, PPARγ was reported to be expressed in several cell lines derived from breast, colon, stomach and lung cancers. Activation of PPARγ by its ligand inhibits the growth of these tumor cells, suggesting that PPARγ ligand is a potential anti‐cancer agent in PPARγ‐expressing tumors. However, its expression in brain tumors has not been studied. We thus studied the expression in glioma samples with different pathological stages from 20 patients. It was demonstrated that 95% of the glioma tissue expressed PPARγ mRNA. The results prompted us to study whether PPARγ ligand affects the growth of cell lines derived from brain tumors. The receptor expression was studied in 9 cell lines either derived from malignant glioma or neuroblastoma. The expression was detected in a glioma cell line SK‐MG‐1 and in a neuroblastoma cell line NB‐1. Addition of one of the PPARγ ligands, troglitazone, induced growth inhibition in both cell lines. Further analyses revealed that this growth inhibition is caused by a PPARγ‐mediated induction of apoptosis. These results suggest that PPARγ ligands could be a potential therapeutic agent for the treatment of the brain tumors expressing this receptor.
Journal of Clinical Investigation | 2000
Takashi Nagaya; Miyuki Fujieda; Goro Otsuka; Jian-Ping Yang; Takashi Okamoto; Hisao Seo
Biochemical and Biophysical Research Communications | 1998
Takashi Nagaya; Miyuki Fujieda; Hisao Seo
Biochemical and Biophysical Research Communications | 1996
Takashi Nagaya; Yoshio Nomura; Miyuki Fujieda; Hisao Seo
Genomics | 1999
Takashi Nagaya; Ken-Shiung Chen; Miyuki Fujieda; Sachiko Ohmori; Jennifer K. Richer; Kathryn B. Horwitz; James R. Lupski; Hisao Seo
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University | 2001
Mihoko Kato; Takashi Nagaya; Miyuki Fujieda; Kiyoshi Saito; Jun Yoshida; Hisao Seo
Archive | 2000
Mihoko Kato; Takashi Nagaya; Miyuki Fujieda; Kiyoshi Saito; Jun Yoshida; Hisao Seo; 加藤 美保子; 長屋 敬; 藤條 美幸; 斉藤 清; 吉田 純; 妹尾 久雄
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University | 2000
Mihoko Kato; Takashi Nagaya; Miyuki Fujieda
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University | 1998
Takashi Nagaya; Miyuki Fujieda; Goro Otsuka; Hisao Seo; 長屋 敬; 藤條 美幸; 大塚 吾郎; 妹尾 久雄
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University | 1997
Takashi Nagaya; Miyuki Fujieda; Sachiko Ohmori