Mjc Houtman
Utrecht University
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Publication
Featured researches published by Mjc Houtman.
British Journal of Pharmacology | 2012
Lukas Nalos; Rosanne Varkevisser; Mkb Jonsson; Mjc Houtman; Jet D.M. Beekman; R. van der Nagel; Morten B. Thomsen; Göran Duker; P Sartipy; T.P. de Boer; Maaike Peschar; Martin B. Rook; Tab Van Veen; Mag Van Der Heyden; M A Vos
Drug development requires the testing of new chemical entities for adverse effects. For cardiac safety screening, improved assays are urgently needed. Isolated adult cardiomyocytes (CM) and human embryonic stem cell‐derived cardiomyocytes (hESC‐CM) could be used to identify pro‐arrhythmic compounds. In the present study, five assays were employed to investigate their sensitivity and specificity for evaluating the pro‐arrhythmic properties of IKr blockers, using moxifloxacin (safe compound) and dofetilide or E‐4031 (unsafe compounds).
British Journal of Pharmacology | 2010
A Oros; Mjc Houtman; P Neco; Am Gomez; S Rajamani; P Oosterhoff; Nj Attevelt; Jet D.M. Beekman; Mag Van Der Heyden; L. Ver Donck; L Belardinelli; S Richard; Gudrun Antoons; M A Vos
BACKGROUND AND PURPOSE The high predisposition to Torsade de Pointes (TdP) in dogs with chronic AV‐block (CAVB) is well documented. The anti‐arrhythmic efficacy and mode of action of Ca2+ channel antagonists, flunarizine and verapamil against TdP were investigated.
British Journal of Pharmacology | 2013
Rosanne Varkevisser; Mjc Houtman; Tobias Linder; K. C. G. de Git; H D M Beekman; Richard R. Tidwell; Adriaan P. IJzerman; Anna Stary-Weinzinger; M A Vos; M. A. G. van der Heyden
Drug interference with normal hERG protein trafficking substantially reduces the channel density in the plasma membrane and thereby poses an arrhythmic threat. The chemical substructures important for hERG trafficking inhibition were investigated using pentamidine as a model drug. Furthermore, the relationship between acute ion channel block and correction of trafficking by dofetilide was studied.
Heart Rhythm | 2013
M A Vos; Mjc Houtman; Gudrun Antoons; H. Takanari; H D M Beekman; T.P. de Boer; S. Rajemani; Luiz Belardinelli; M. A. G. van der Heyden
Archive | 2009
Mohamed Boulaksil; Jérôme Gm Jungschleger; Gudrun Antoons; Mjc Houtman; T.P. de Boer; R. Wilders; Jet D.M. Beekman; Jos G. Maessen; Ff van der Hulst; T. A. B. van Veen; M. A. G. van der Heyden; H.V.M. van Rijen; J. M. T. de Bakker; M A Vos
Europace | 2018
Iah Ter Horst; Alexandre Bossu; Mjc Houtman; Hdm Beekman; W M Van Everdingen; S Korte; Mathias Meine; T.P. de Boer; M A Vos
Europace | 2017
Y. Ji; Mjc Houtman; F. Romunde; D. Fransen; Ap. Ijzerman; Lh. Heitman; M A Vos; Mag Van Der Heyden
Europace | 2017
M. Qile; Y. Ji; Mjc Houtman; F. Romunde; M. Veldhuis; Bart Kok; M A Vos; Mag Van Der Heyden
Europace | 2017
Mag Van Der Heyden; Marlieke G. Veldhuis; J. Zandvoort; Mjc Houtman; Karen Duran; G. Van Haaften; Em. Zangerl-Plessl; H. Takanari; Anna Stary-Weinzinger; Yuan Ji
Europace | 2017
Alexandre Bossu; Mjc Houtman; Hdm Beekman; Mag Van Der Heyden; M A Vos
