Moein Mozaffarzadeh

Double-Stage Delay Multiply and Sum Beamforming Algorithm: Application to Linear-Array Photoacoustic Imaging

Photoacoustic imaging (PAI) is an emerging medical imaging modality capable of providing high spatial resolution of Ultrasound (US) imaging and high contrast of optical imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm in PAI. However, using DAS beamformer leads to low resolution images and considerable contribution of off-axis signals. A new paradigm namely delay-multiply-and-sum (DMAS), which was originally used as a reconstruction algorithm in confocal microwave imaging, was introduced to overcome the challenges in DAS. DMAS was used in PAI systems and it was shown that this algorithm results in resolution improvement and sidelobe degrading. However, DMAS is still sensitive to high levels of noise, and resolution improvement is not satisfying. Here, we propose a novel algorithm based on DAS algebra inside DMAS formula expansion, double stage DMAS (DS-DMAS), which improves the image resolution and levels of sidelobe, and is much less sensitive to high level of noise compared to DMAS. The performance of DS-DMAS algorithm is evaluated numerically and experimentally. The resulted images are evaluated qualitatively and quantitatively using established quality metrics including signal-to-noise ratio (SNR), full-width-half-maximum (FWHM) and contrast ratio (CR). It is shown that DS-DMAS outperforms DAS and DMAS at the expense of higher computational load. DS-DMAS reduces the lateral valley for about 15 dB and improves the SNR and FWHM better than 13% and 30%, respectively. Moreover, the levels of sidelobe are reduced for about 10 dB in comparison with those in DMAS.

Medical photoacoustic beamforming using minimum variance-based delay multiply and sum

Delay-and-Sum (DAS) beamformer is the most common beamforming algorithm in Photoacoustic imaging (PAI) due to its simple implementation and real time imaging. However, it provides poor resolution and high levels of sidelobe. A new algorithm named Delay-Multiply-and-Sum (DMAS) was introduced. Using DMAS leads to lower levels of sidelobe compared to DAS, but resolution is not satisfying yet. In this paper, a novel beamformer is introduced based on the combination of Minimum Variance (MV) adaptive beamforming and DMAS, so-called Minimum Variance-Based DMAS (MVB-DMAS). It is shown that expanding the DMAS equation leads to some terms which contain a DAS equation. It is proposed to use MV adaptive beamformer instead of existing DAS inside the DMAS algebra expansion. MVB-DMAS is evaluated numerically compared to DAS, DMAS and MV and Signal-to-noise ratio (SNR) metric is presented. It is shown that MVB-DMAS leads to higher image quality and SNR for about 13 dB, 3 dB and 2 dB in comparison with DAS, DMAS and MV, respectively.

Image enhancement and noise reduction using modified Delay-Multiply-and-Sum beamformer: Application to medical photoacoustic imaging

Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging. Since receiving part of PA consists of US waves, a large number of beamforming algorithms in US imaging can be applied on PA imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm in US imaging. However, make use of DAS beamformer leads to low resolution images and large scale of off-axis signals contribution. To address these problems, a new paradigm namely Delay-Multiply-and-Sum (DMAS), which was used as a reconstruction algorithm in confocal microwave imaging for breast cancer detection, was introduced for US imaging. Consequently, DMAS was used in PA imaging systems and it was shown this algorithm results in resolution enhancement and sidelobe degrading. However, in presence of high level of noise the reconstructed, image still suffers from high contribution of noise. In this paper, a modified version of DMAS beamforming algorithm is proposed based on DAS inside DMAS formula expansion. The quantitative and qualitative results show that proposed method results in more noise reduction and resolution enhancement at the expense of higher computational burden. For the simulation, two-point target, along with lateral variation in two depths of imaging are employed, and it is evaluated under high level of noise in imaging medium. Proposed algorithm, in comparison with DMAS, results in reduction of lateral valley for about 19 dB followed by more distinguished two-point target. Moreover, levels of sidelobe are reduced for about 25 dB.

Double-Stage Delay Multiply and Sum Beamforming Algorithm Applied to Ultrasound Medical Imaging

In ultrasound (US) imaging, delay and sum (DAS) is the most common beamformer, but it leads to low-quality images. Delay multiply and sum (DMAS) was introduced to address this problem. However, the reconstructed images using DMAS still suffer from the level of side lobes and low noise suppression. Here, a novel beamforming algorithm is introduced based on expansion of the DMAS formula. We found that there is a DAS algebra inside the expansion, and we proposed use of the DMAS instead of the DAS algebra. The introduced method, namely double-stage DMAS (DS-DMAS), is evaluated numerically and experimentally. The quantitative results indicate that DS-DMAS results in an approximately 25% lower level of side lobes compared with DMAS. Moreover, the introduced method leads to 23%, 22% and 43% improvement in signal-to-noise ratio, full width at half-maximum and contrast ratio, respectively, compared with the DMAS beamformer.

Eigenspace-based minimum variance adaptive beamformer combined with delay multiply and sum: experimental study

Delay and sum (DAS) is the most common beamforming algorithm in linear-array photoacoustic imaging (PAI) as a result of its simple implementation. However, it leads to a low resolution and high sidelobes. Delay multiply and sum (DMAS) was used to address the incapabilities of DAS, providing a higher image quality. However, the resolution improvement is not well enough compared to eigenspace-based minimum variance (EIBMV). In this paper, the EIBMV beamformer has been combined with DMAS algebra, called EIBMV-DMAS, using the expansion of DMAS algorithm. The proposed method is used as the reconstruction algorithm in linear-array PAI. EIBMV-DMAS is experimentally evaluated where the quantitative and qualitative results show that it outperforms DAS, DMAS and EIBMV. The proposed method degrades the sidelobes for about 365 %, 221 % and 40 %, compared to DAS, DMAS and EIBMV, respectively. Moreover, EIBMV-DMAS improves the SNR about 158 %, 63 % and 20 %, respectively.

Photoacoustic image formation based on sparse regularization of minimum variance beamformer

Delay-and-sum (DAS) is the most common algorithm used in photoacoustic (PA) image formation. However, this algorithm results in a reconstructed image with a wide mainlobe and high level of sidelobes. Minimum variance (MV), as an adaptive beamformer, overcomes these limitations and improves the image resolution and contrast. In this paper, a novel algorithm, named Modified-Sparse-MV (MS-MV), is proposed in which a ℓ 1-norm constraint is added to the MV minimization problem after some modifications, in order to suppress the sidelobes more efficiently, compared to MV. The added constraint can be interpreted as the sparsity of the output of the MV beamformed signals. Since the final minimization problem is convex, it can be solved efficiently using a simple iterative algorithm. The numerical results show that the proposed method, MS-MV beamformer, improves the signal-to-noise (SNR) about 19.48 dB, in average, compared to MV. Also, the experimental results, using a wire-target phantom, show that MS-MV leads to SNR improvement of about 2.64 dB in comparison with the MV.

Model-based photoacoustic image reconstruction using compressed sensing and smoothed L0 norm

Photoacoustic imaging (PAI) is a novel medical imaging modality that uses the advantages of the spatial resolution of ultrasound imaging and the high contrast of pure optical imaging. Analytical algorithms are usually employed to reconstruct the photoacoustic (PA) images as a results of their simple implementation. However, they provide a low accurate image. Model-based (MB) algorithms are used to improve the image quality and accuracy while a large number of transducers and data acquisition are needed. In this paper, we have combined the theory of compressed sensing (CS) with MB algorithms to reduce the number of transducer. Smoothed version of ℓ0-norm (Sℓ0) was proposed as the reconstruction method, and it was compared with simple iterative reconstruction (IR) and basis pursuit. The results show that Sℓ0 provides a higher image quality in comparison with other methods while a low number of transducers were. Quantitative comparison demonstrates that, at the same condition, the Sℓ0 leads to a peak-signal-to-noise ratio for about two times of the basis pursuit.

Validation of Delay-Multiply-and-Standard-Deviation Weighting Factor for Improved Photoacoustic Imaging of Sentinel Lymph Node

Delay-and-sum (DAS) is one of the most common algorithms used to construct the photoacoustic images due to its low complexity. However, it results in images with high sidelobes and low resolution. Delay-and-standard-deviation (DASD) weighting factor can improve the contrast of the images compared to DAS. However, it still suffers from high sidelobes. In this work, a new weighting factor, named delay-multiply-and-standard-deviation (DMASD) is introduced to enhance the contrast of the reconstructed images compared to other mentioned methods. In the proposed method, the SD of the mutual multiplied delayed signals are calculated, normalized and multiplied to DAS beamformed data. The results show that DMASD improves the signal-to-noise-ratio about 19.29 and 7.3 dB compared to DAS and DASD, respectively, for in vivo imaging of the sentinel lymph node. Moreover, the contrast ratio is improved by the DMASD about 23.61 and 10.81 dB compared to DAS and DASD, respectively.