Mohamed Akssira

Synthesis of chiral 3-substituted 2,4(1H,3H)-quinazolinediones

2-Carbomethoxyphenyl isocyanate and 6-nitro-2-carbomethoxyphenyl isocyanate were generated in situ from half-esters, and then converted into the corresponding quinazolinediones using α-amino acids. This useful annelation process was found to be a general method for the formation of various chiral 3-substituted quinazolinediones

Synthesis of novel 5a,10,14b,15-tetraaza-benzo[a]indeno[1,2-c]anthracen-5-one and benzimidazo[1,2-c]quinazoline derivatives under microwave irradiation

Novel 5a,10,14b,15-tetraaza-benzo[a]indeno[1,2-c]anthracen-5-one and benzimidazo[1,2-c]quinazoline derivatives were synthesised in good yields in two or three steps from 2-(2-aminophenyl)indole and 2-(2-aminophenyl)benzimidazole. Microwave irradiation in homogeneous phase or in dry media was used in order to improve reactions where conventional heating (metal or oil bath) was limited.

A facile and general route to 4-substituted-2 butenolides

Abstract Grignard reagents react with 7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydride and produce in high yields the corresponding substituted bicyclo-γ-butanolides. These lactones produce the title compounds by retro Diels-Alder reaction during distillation.

Alkylation des lactones tricycliques pontees. Application a la synthese des butenolides trisubstitues en 2 et 4

Abstract Disubstituted endo tricyclic lactones have been prepared by the reaction of primary alkylmagnesium compounds with the endo bicyclo [ 2.2.1 ] hept-5-ene-2, 3 dicarboxylic anhydride. These lactones were alkylated and transformed into corresponding 3,5,5-trialkyl-2(5H) furanones.

Nouvelle application des anhydrides N-carboxy aminoacides : synthese des 1,4-benzodiazepine-2,5-diones

Abstract A new synthetic method for 1,4-benzodiazepine-2,5-dione (BZD) was accomplished by the coupling of amino acid N-carboxy anhydrides (NCAs) with Boc-anthranilic acid, followed by the deprotection of Boc group and by the ring expansion.

Nouvelle méthode de synthèse des γ-lactones et (5H)furannones-2-monosubstituées

Abstract 3-monosubstituted γ-lactones and 5-mono- or 3,5-disubstituted 2-(5-H)-furanones have been prepared by the reaction of Grignard reagents with lactols.

A Convenient Synthesis of Some Highly Hindered 4,4-Diaryl-2-Butenolides

Abstract Bridged di(o-alkylaryl) tricyclic-γ-lactones have not been described in the literature and their preparation may be difficult by published methods. As a part of our studies on Grignard reactions with cyclic anhydrides1-3 we describe herein a new and important aspect of the reaction of hindered magnesium compounds with exo 7-oxabicyclo[2.2.1]hept-4-ene-2,3-dicarboxylic anhydride.

L'importance de la presence de l'oxygene en position-7 dans les reactions des alkylmagnesiens secondaires avec les anhydrides tricycliques pontes.

Abstract The reaction of secondary alkylmagnesium bromides with endo and exo bicyclo-[2.2.1]hept-5-ene-2,3-dicarboxylic anhydrides lead at the corresponding ketoacids whereas with the 7-oxa exo bicyclo[2.2.1]hept-5-ene-2,3 dicarboxylic anhydride produced only the monosubstituted lactones.

Reactions stéréosélectives des alkylmagnésiens secondaires avec les anhydrides et lactones rigides

Abstract High stereoselectivity was observed in the reactions of secondary alkylmagnesium compounds with bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydride 1 and lactone 2 leading respectively to the formation of trans diastereomeric lactones and erythro primary-secondary diols.

Nouvelle application de l'anhydride oxa-7 exo bicyclo [2.2.1] heptène-5 dicarboxylique 2,3. Synthèse des α-furyl γ-cetoacides

Resume Reactions of alkylmagnesium bromides with 7-oxa-bicyclo [2.2.1] hept-5-ene-2,3 di-carboxylic anhydride at −70°C lead to the formation of α-furyl γ-ketoacides