E. Mohamed

Potentiometric and Visual Titrimetric Methods for Analysis of Captopril and Its Pharmaceutical Forms

Abstract Captopril, a new anihypertensive agent, has been assayed in authenitic as well as in tablet (Capoten((R))Manufacture: Squibb and Sons, Inc., Princeton, N.J., U.S.A. dosage forms by applying potentiometric visual, argentometric and oxidometric methods of idoine and cupric ion. Each method of assay involves the determination of captopril in a given weight of sample. Six samples were run for each method and the average percentages of recovery of captopril from its tablets were computed. For the potentiometric and visual silver methods the average percentages of recovery are 103.3 ± 1.2 and 102.3 ± 1.0 respectively. For the oxidometic methods of iodine and cupric ion, the average percentages of recovery are 103.8 ± 1.5 and 104.2 ± 1.4 respectively.

Liquid chromatographic determination of amoxycillin and clavulanic acid in pharmaceutical preparations

A liquid chromatographic method for the simultaneous determination of amoxycillin and potassium clavulanate in tablet and suspension preparations is presented. The method specifies reversed phase column and a buffered mobile phase (CH3OH + KH2PO4-buffer pH 6 + H2O, 15:1:84) isocratically at a rate of 1.0 ml min-1, with detection at 235 nm. The suitability of the chromatographic system developed is tested using replicate injections of the sample and standard preparations. The observed relative standard deviations (RSDs) were within 2%. Recovery experiments conducted utilizing the proposed method gives results of 101.5% +/- 1.72 (n = 6) and 101.22% +/- 1.93 (n = 6) for amoxycillin in tablets and powder for oral administration, respectively. Similarly, recovery experiments for clavulanic acid gave results of 100.33 +/- 1.90 (n = 6) and 99.61 +/- 1.32 (n = 6) in the tablets and suspension powder, respectively. Comparison of the proposed method with the USP method proved it to be satisfactory. The statistical F- and t-tests observed, indicated that there were no significant differences between the two methods regarding precision and accuracy.

First-Derivative Spectrophotometric Determination of a Mixture of Pirbuterol Hydrochloride and Butorphanol Tartrate

Abstract Vierordts method, its modified version and the first derivative method have been applied for the simultaneous determination of butorphanol tartrate and pirbuterol hydrochloride in laboratory mixtures of authemtic and dosage forms. The first derivative spectrophotometric method yields accurate and reprodeucible results for both drugs. Mean percent recoveries for butorphanol tartrate and pirbuterol hydrochloride in dosage forms were 100.54±0.84 and 100.42±1.27, respectively. Virrordts method and its modified version have given unreliable results; the reasons behind have been discussed.

Spectrophotometric determination of amoxycillin and clavulanic acid in pharmaceutical preparation.

A spectrophotometric procedure for the simultaneous determination of amoxycillin and clavulanic acid in some pharmaceutical preparations has been developed. As the absorption bands of amoxycillin (274 and 227 nm) and clavulanic acid (270 nm) overlap, both Vierordts method and derivative spectrophotometry have been investigated and evaluated. The first-derivative spectrophotometric method was found to be more accurate, direct and reproducible.

Spectrophotometric Determination of Timolol and Other β-adrenergic Blocking Drugs and in Pharmaceutical Preparations

Abstract Introduction: β-adrenergic blocking drugs are presently used for the treatment of diseases characterised by excess sympathetic nervous acitivity. These illnesses range from cardiac arrhythmia, sinus tachycardia, angina pectoris, hypertension to migraine.

Amperometric and conductimetric methods for simultaneous determination of captopril and bendroflumethiazide

Abstract The mixture of captopril (antihypertensive) and bendroflumethiazide (diuretic) was assayed using conductimetric and amperometric methods. Each method was applied for the analysis of laboratory-made sample mixtures in authentic and dosage forms. For captopril, the amperometric and conductimetric methods gave mean percent recoveries of 100.2 ± 1.2 and 99.6 ± 1.2, respectively. These results have shown good agreement when compared with other methods in the literature. When applied to bendroflumethiazide the conductimetric method gave percent recovery of 98.5 ± 1.6 which agreed closely with the spectrophotometric pharmacopoeial method. The pK1 for captopril was determined potentiometrically at room temperature (25°C) in aqueous medium. The calculated value, based on Henderson equation was 3.78.

SPECTROPHOTOMETRIC AND DIFFERENTIAL PULSE POLAROGRAPHIC METHODS OF ANALYSIS FOR KETOTIFEN HYDROGEN FUMARATE

AbstractSpectrophotometric and differential pulse polarographic methods have been proposed for the assay of ketotifen hydrogen fumarate in authentic powder and in capsule dosage forms (Zaditen(R)), using acetate buffer of pH 5.0 as a solvent as well as a supporting electrolyte. Ketotifen hydrogen fumarate exhibits relatively strong absorption in the ultraviolet region with maximum absorption at 300 nm; the molar absorptivity,

Colorimetric Determination of Tranexamic Acid with p-Dimethylaminobenzaldehyde

ePmax, and specific absorbance, A (1 per cent, 1 cm), being 1.38 × 4 L mole−1 cm−1 and 325 respectively. Beers Law was verified; the absorbance, (Amax), was found to be linearly related to concentration, C, over the range 2 to 30 ug ml−1. The mean percentages of recovery for ketotifen hydrogen fumarate powder and in capsule form obtained spectrophotometrically were 100.85

Potentiometric Non Aqueous Determination of Glaphenine Hydrochloride and in Its Pharmaceutical Formulations

pM 0.56 and 99.75

Spectrophotometric Method of Determination for Cycloserine Using Chlornil

pM 0.85 respectively.Differential pulse polarograms were recorded at room temperature under constant pulse amplitude of 50 mV superimposed on a linearly increasing DC-voltage ramp. The peak cur...