Mohamed El-Sherbiny

Nonoperative Management of Grade 5 Renal Injury in Children: Does It Have a Place?

BACKGROUNDnNonoperative treatment of blunt renal trauma in children is progressively gaining acceptance; grade 5 renal trauma is associated with a significant rate of complications.nnnOBJECTIVEnTo assess the feasibility and outcome of initial nonoperative management of grade 5 blunt renal trauma in children.nnnDESIGN, SETTING, AND PARTICIPANTSnThis retrospective study included 18 children (12 boys and 6 girls; mean age: 8.4+/-3.4 yr) who presented to the authors institutes with grade 5 blunt renal trauma between 1990 and 2007.nnnMEASUREMENTSnAn intravenous contrast-enhanced computed tomography (CT) scan demonstrated grade 5 renal trauma in all patients. Associated major vascular injuries were suspected in four patients. All were initially managed conservatively. Indications for intervention included hemodynamic instability, progressive urinoma, or persistent bleeding. Dimercaptosuccinic acid (DMSA) scans were performed at a mean time of 3.1 yr (range: 1-17) following the injury in nine patients.nnnRESULTS AND LIMITATIONSnFour patients (22%) with suspected major vascular injuries required nephrectomy 1-21 d following the trauma. Two patients with continuing hemorrhage required selective lower-pole arterial embolization (11%). Three patients (17%) had their progressive urinoma drained percutaneously, and two of them required delayed reparative surgery for ureteropelvic junction (UPJ) avulsion. Nine patients (50%) were successfully managed nonoperatively. Kidneys were salvaged in 78% of patients. DMSA scanning showed a split function >40% in 44% of evaluated kidneys. Two patients (22%) had split function <30%. At last follow-up, none of the children were hypertensive or had any abnormality on urine analysis.nnnCONCLUSIONSnNonoperative management of grade 5 renal trauma is feasible. Prompt surgical intervention is required for those with major vascular injuries. Superselective arterial embolization can be an excellent option in patients with continuing hemorrhage and who have pseudoaneurysms. Patients with UPJ disruption can be salvaged by initial drainage of the urinoma followed by deferred correction.

Is routine renography required after pyeloplasty

PURPOSEnWe assessed whether renography should be performed routinely following pyeloplasty.nnnMATERIALS AND METHODSnWe identified the records of all patients undergoing pyeloplasty at our hospital between 1989 and 2005. Patients were eligible for the study if they had undergone preoperative ultrasound and renal scan, and postoperative ultrasound and renal scan within 3 months and 1 year postoperatively, respectively. Patients were excluded if they had associated anomalies or high grade reflux. Postoperative downgrading or decompression of the pelvicaliceal dilatation within the same grade was recorded as improved, while unchanged or worsening hydronephrosis was recorded as no improvement. All information was obtained from the official radiologist reports rather than from the postoperative surgeon notes. Data obtained from the postoperative renal scan included the presence or absence of obstruction as well as split renal function. We compared postoperative ultrasound and renal scan, as well as changes between preoperative and postoperative split renal function in patients with a normal contralateral kidney. Fishers exact test was used for comparison.nnnRESULTSnA total of 97 patients who underwent 101 pyeloplasties at a median age of 18 months were eligible for review. Mean +/- SD followup was 4.5 +/- 2 years. Of the 91 kidneys with improvement on postoperative ultrasound 2 (2%) had an obstructive postoperative renal scan, which spontaneously resolved during followup. In contrast, of the 10 kidneys with postoperative ultrasound showing no improvement 4 (40%) had an obstructive renal scan, of which 2 (50%) required a second procedure (p <0.001). Of the 46 kidneys with downgraded hydronephrosis none had an obstructive postoperative renal scan, compared to 6 of 55 (11%) without downgrading (p <0.03). Of the 49 patients with preoperative split renal function greater than 45% none demonstrated changes of more than 5% postoperatively, compared to 15 of 35 (43%) with split renal function less than 45% (p <0.001).nnnCONCLUSIONSnPatients in whom postoperative ultrasound reveals downgrading may not require postoperative renal scan to rule out obstruction. However, those with preoperative function less than 45% may exhibit functional changes greater than 5% that can be determined by postoperative renal scan.

The Role of Bladder Urine Transforming Growth Factor-β1 Concentrations in Diagnosis and Management of Unilateral Prenatal Hydronephrosis

PURPOSEnWe evaluated the relationship between bladder urine transforming growth factor-beta1 concentration and severity of hydronephrosis in newborns with unilateral prenatal hydronephrosis.nnnMATERIALS AND METHODSnWe prospectively studied all newborns presenting with unilateral prenatal hydronephrosis between January 2005 and 2007. Patients with associated anomalies, vesicoureteral reflux, contralateral pathology or ipsilateral ureteral dilatation were excluded from study. Postnatal evaluation included voiding cystourethrography, renal ultrasonography and determination of bladder urine transforming growth factor-beta1 concentration. Diuretic renal scans were performed in patients with initial grade 3 or 4 hydronephrosis or increasing hydronephrosis during followup. Pyeloplasty was performed when a well tempered renogram showed an obstructive drainage curve with a half-time greater than 20 minutes and/or an obstructive washout curve pattern during the diuretic phase. Patients were analyzed in observational and surgical groups. We studied the longitudinal changes in bladder urine transforming growth factor-beta1 in each group and compared concentration levels in the first 3 months of life in both groups.nnnRESULTSnA total of 42 newborns were included. The observational group consisted of 31 patients followed for a mean of 14 +/- 6 months. During the first 3 months, from 3 to 12 months and in the second year of life mean ultrasound grade and bladder urine transforming growth factor-beta1 decreased from 2.3 to 1.7 to 1.2 (p <0.05) and from 11.5 to 8.6 to 6.1 pg/mmol creatinine (p <0.05), respectively. Pyeloplasty was performed in 11 patients at a mean age of 6 +/- 5 months. Mean followup was 7 +/- 5 months. In the first 3 months, preoperatively and at 3 to 12 months postoperatively mean ultrasound grade and bladder urine transforming growth factor-beta1 were 3.5, 4 and 3 (p >0.05), and 23, 29 (p >0.05) and 8 pg/mmol creatinine (p <0.003), respectively. Mean bladder urine transforming growth factor-beta1 levels in the first 3 months of life were 23 +/- 14 and 11.5 +/- 8 pg/mmol creatinine in the surgical and observational groups, respectively (p <0.001). Limiting comparison to the 23 patients with initial grades 3 and 4 hydronephrosis revealed levels of 23 +/- 14 and 13 +/- 9 pg/mmol creatinine in the surgical and observational groups, respectively (p <0.02). At a cutoff of 17 pg/mmol creatinine bladder urine transforming growth factor-beta1 in the first 3 months of life was 82% sensitive and 86% specific in predicting surgery.nnnCONCLUSIONSnBladder urine transforming growth factor-beta1 changes through time are associated with similar changes in hydronephrosis grade. Bladder urine transforming growth factor-beta1 in the first 3 months of life can predict the need for surgery in newborns with prenatal hydronephrosis.

Evaluation of Urinary Tract Dilation Classification System for Grading Postnatal Hydronephrosis.

PURPOSEnWe assessed the reliability and validity of the Urinary Tract Dilation classification system as a new grading system for postnatal hydronephrosis.nnnMATERIALS AND METHODSnWe retrospectively reviewed charts of patients who presented with hydronephrosis from 2008 to 2013. We included patients diagnosed prenatally and those with hydronephrosis discovered incidentally during the first year of life. We excluded cases involving urinary tract infection, neurogenic bladder and chromosomal anomalies, those associated with extraurinary congenital malformations and those with followup of less than 24 months without resolution. Hydronephrosis was graded postnatally using the Society for Fetal Urology system, and then the management protocol was chosen. All units were regraded using the Urinary Tract Dilation classification system and compared to the Society for Fetal Urology system to assess reliability. Univariate and multivariate analyses were performed to assess the validity of the Urinary Tract Dilation classification system in predicting hydronephrosis resolution and surgical intervention.nnnRESULTSnA total of 490 patients (730 renal units) were eligible to participate. The Urinary Tract Dilation classification system was reliable in the assessment of hydronephrosis (parallel forms 0.92). Hydronephrosis resolved in 357 units (49%), and 86 units (12%) were managed by surgical intervention. The remainder of renal units demonstrated stable or improved hydronephrosis. Multivariate analysis revealed that the likelihood of surgical intervention was predicted independently by Urinary Tract Dilation classification system risk group, while Society for Fetal Urology grades were predictive of likelihood of resolution.nnnCONCLUSIONSnThe Urinary Tract Dilation classification system is reliable for evaluation of postnatal hydronephrosis and is valid in predicting surgical intervention.

A novel technique of stenting for laparoscopic pyeloplasty in children.

PURPOSEnWe introduce the novel technique of a percutaneous pyelo-ureterostomy stent for laparoscopic pyeloplasty in children, which overcomes the limitations of previously described stenting techniques.nnnMATERIALS AND METHODSnA Chiba needle is passed percutaneously across the anterior wall of the renal pelvis after completion of the anterior pyelo-ureteric anastamotic line. A guide wire is inserted through the trocar followed by an angiocatheter over the wire. The stent is passed through the angiocatheter, over the wire and across the wall of the renal pelvis. The wire is withdrawn and the stent distal tip is advanced to the mid-ureter. The posterior anastamotic line is then completed and the renal pelvis closed. The stent is capped on postoperative day 1 and removed in the office on postoperative day 10.nnnRESULTSnSince 2007 we have used this approach for 14 laparoscopic pyeloplasties (5 right, 9 left) in children with a mean age of 8.8 years (range 5-17). Mean time of insertion was 9:55 min with no difficulties or perioperative complications noted.nnnCONCLUSIONnThe antegrade pyelo-ureteral stent is easily and quickly inserted percutaneously as well as removed in the office, thus obviating the need for a second anesthetic.

The anterior approach to retroperitoneoscopic adrenalectomy in children: Technique

PURPOSEnVery limited literature exists on minimally invasive adrenalectomy in children. Retroperitoneoscopic adrenalectomy (RPA) has the advantage of avoiding intra-abdominal organ retraction, but concerns have been expressed regarding RPA on the right side. Herein, we describe the second reported experience with the anterior approach to RPA in children, which appears to overcome the limitations previously ascribed to right RPA.nnnMATERIALS AND METHODSnTwo children, aged 8 and 14-years, presented with incidental right adrenal masses. Both patients were placed in the lateral decubitus position with lumbar hyper-extension. A 5-mm, 3-port approach was used, as demonstrated in the video.nnnRESULTSnPathology revealed a 7-cm ganglioneuroma and a 5-cm pheochromocytoma with intact surgical margins. Operative time with these large masses and first experience with this technique was 5 h in the first case and 3.5 h in the second. No intraoperative or postoperative complications were noted, with minimal blood loss and a hospital stay of 36 h in both cases.nnnCONCLUSIONnThe anterior approach to RPA is feasible even in children with a smaller retroperitoneal space and a large adrenal mass. It provides excellent exposure of the adrenal gland and vein, even on the right side.

How Much Does the Midline Incision Add to Urethral Diameter After Tubularized Incised Plate Urethroplasty? An Experimental Animal Study

PURPOSEnWe objectively quantified the gain in urethral diameter and the effect of stenting after tubularized incised plate urethroplasty in a rabbit hypospadias model.nnnMATERIALS AND METHODSnWe created a hypospadias model in 12 New Zealand white male rabbits by excising the ventral urethra. A 3 cm tattoo line was made longitudinally in the dorsal urethral plate midline. Two weeks later a 2 cm relaxing incision was made in the middle part of the tattooed line. The stretched incision width between the tattooed edges was measured, followed by urethral plate tubularization. Six rabbits were stented and 6 were nonstented. Two weeks later the animals were sacrificed and the distance separating the tattoo was measured at the midpoint of the tattooed line. Transverse sections at this point were examined histologically.nnnRESULTSnAll animals survived the procedures. Stents were removed at 7 days in 4 rabbits and fell out in 2 at 4 and 2 days, respectively. The mean ± SD incision width of 5.5 ± 1.6 mm (range 3 to 8) at tubularization became 2 ± 0.5 mm (range 1 to 3) after healing (p <0.002). Mean width of the healed incision was 1.7 ± 0.4 (range 1 to 2) vs 2.3 ± 0.5 mm (range 1.5 to 3) in the nonstented and stented groups, respectively (p <0.06). Rabbits with a stenting duration of less than 7 days were excluded from the last analysis. Histologically all incisions healed completely with an intact epithelium.nnnCONCLUSIONSnThe initial width of the midline relaxing incision significantly decreased after complete epithelialization. The average gain in urethral width was only 2 mm. Stenting appeared to increase the width of the healed incisions but not in a statistically significant manner.

Dye-assisted lymphatic-sparing laparoscopic varicocelectomy in children

INTRODUCTIONnThe ideal method for varicocelectomy in children remains controversial. We present our experience with dye-assisted lymphatic-sparing laparoscopic varicocelectomy (LSLV) in children, which overcomes the limitations of previously described techniques.nnnMATERIALS AND METHODSnTwenty-five consecutive LSLVs were performed on children with a mean age of 15 years over a 4-year period. Varicocele grade was 3 in 21 cases and grade 2 in 4. Indications for intervention were hypotrophy in 12, pain in 11 cases and family preference in 2. A scrotal injection of lymphatic dye was utilized to spare at least one lymphatic and the remaining spermatic vessels were divided.nnnRESULTSnLymphatic sparing was accomplished in all cases. Operative time varied from 30 to 140 min (mean 85 ± 26). No perioperative complications were noted. On average follow-up of 13 months a residual varicocele was noted in 2 cases, with no hydrocele and resolution of pain. Mean testicular volume difference diminished from 33% pre to 18% postoperatively.nnnCONCLUSIONnThis multi-surgeon experience demonstrates that dye-assisted LSLV is easily accomplished with promising results. It appears that preservation of a single spermatic lymphatic vessel is sufficient, although in some cases a second dye injection is required to visualize the lymphatics.

Comprehensive analysis of the clinical and urodynamic outcomes of secondary tethered spinal cord before and after spinal cord untethering

OBJECTIVEnSecondary tethering of the spinal cord (TSC) occurs in 3-30% of patients with history of spinal cord dysraphism repair. As many patients with spinal cord dysraphism already have symptoms, it might be difficult to diagnose secondary TSC. Regular clinical/urodynamic (UDS) evaluation is therefore advised to pick-up changes early before they progress. This study aimed at presenting clinical/UDS outcomes for patients with secondary TSC who underwent spinal cord untethering (SCU).nnnSTUDY DESIGNnCharts of patients with secondary TSC between 1998 and 2010 were reviewed retrospectively. Patients who underwent pre/post SCU clinical/UDS evaluation were included. All patients were followed-up for a minimum of 5 years for proper clinical outcomes assessment. Urologic, neuro-orthopedic, and UDS outcomes were collected and studied. Continence status was assessed in children aged ≥5 years. Patients were considered continent if they were dry for ≥4 h or socially continent if they stayed dry most of the day using maximum 1-2 pads/day. Categorical data were compared using the Fisher-Exact test and continuous variables were compared using the Wilcoxon Signed Rank test. A p-value < 0.05 was considered significant.nnnRESULTSnTwenty-three patients met our inclusion criteria. The median age at time of SCU was 8.8 (range 2.3-16.2) years. The median age at time of UDS follow-up after SCU was 8.8 (range 2.9-17) years. The median follow-up time was 5 (range 5-13.4) years. Urological symptoms were reported in 56.5% of patients before SCU and improved in 61.5% post SCU. Neuro-orthopedic symptoms were reported in 87% of patients before SCU and improved in 65% post SCU. Continence was achieved in 73.9% of the entire cohort on long-term follow-up, while 26.1% had socially acceptable continence. UDS outcomes are summarized in the Table.nnnCONCLUSIONSnPatients with secondary TSC are expected to have progression of their symptoms over time if not untethered. From here comes the importance of closely performing clinical/UDS evaluation to pick-up changes early before they progress. Surprisingly, clinical outcomes after SCU with detailed description of the auxiliary management are sparse in the literature. Most studies focus on UDS outcomes. We provided in the current study a detailed discussion of the clinical outcomes, auxiliary-managements used to achieve continence, and the UDS outcomes. Careful periodic clinical/UDS evaluation is recommended for early pick-up of changes suggestive of TSC. SCU could improve existing symptoms, and prevent worsening or development of new symptoms. UDS parameters that showed most improvement were intravesical pressure at TCBC and bladder compliance.

Disorders of sexual differentiation: I. Genetics and pathology

Abstract Objectives: To provide a summary of the recent major advances in the field of molecular genetics and understanding of psychosexual development, as these developments have resulted in changes in terminology and classification of disorders of sexual differentiation (DSD)/intersex; and to provide a quick and simplified review of the basic information. Methods: Recent publications (over the last 10 years) were identified by a PubMed search, as were relevant previous studies, using the keywords; ‘sex chromosomes’, ‘psychosexual development’, ‘classifications’, ‘disorders of sexual differentiation’, ‘Chicago consensus’, ‘gonadal malignancy’, ‘intersex’ and ‘ambiguous genitalia’. Results: The newly proposed terminology and classification has eliminated some confusion for both patient and family, as well as among health professionals. The new advances have facilitated the categorisation of gonadal malignancy in patients with DSD into high-, intermediate- and low-risk groups. Conclusions: The major changes in terminology and classification of DSD should be considered as the first steps on a long road of research effort. The current available data remain far from sufficient. More molecular genetics studies will allow a better understanding of the causes of each condition of DSD.