Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Mohamed I. S. Abdelhady is active.

Publication


Featured researches published by Mohamed I. S. Abdelhady.


Plant Molecular Biology | 2009

Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors

Mohamed I. S. Abdelhady; Till Beuerle; Dietrich Ober

Homospermidine synthase is the first specific enzyme in the biosynthesis of pyrrolizidine alkaloids. Whereas the substrates putrescine and spermidine are part of the highly dynamic polyamine pool of plants, the product homospermidine is incorporated exclusively into the necine base moiety of pyrrolizidine alkaloids. Recently, the gene encoding homospermidine synthase has been shown to have been recruited several times independently during angiosperm evolution by the duplication of the gene encoding deoxyhypusine synthase. To test whether high levels of homospermidine suffice for conversion, at least in traces, to precursors of pyrrolizidine alkaloids, transgenic tobacco plants were generated expressing homospermidine synthase. Analyses of the polyamine content revealed that, in the transgenic plants, about 80% of spermidine was replaced by homospermidine without any conspicuous modifications of the phenotype. Tracer-feeding experiments and gas chromatographic analyses suggested that these high levels of homospermidine were not sufficient to explain the formation of alkaloid precursors. These results are discussed with respect to current models of pathway evolution.


Pharmaceutical Biology | 2011

Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala

Eman G. Haggag; Amel M. Kamal; Mohamed I. S. Abdelhady; Mortada M. El-Sayed; Eman A. El-Wakil; Sayed S. Abd-El-hamed

Context: Cancer is a serious clinical problem to the health care system. Anticancer drugs have been extracted from plants containing phenolic compounds. Leucenia species (Fabaceae) contain a variety of bioactive components of numerous biological and pharmacological properties. Objective: This study explored the constitutive polyphenols of Leucenia leucocephala Lam. growing in Egypt and evaluated the antioxidant and cytotoxic activity. Materials and methods: Chemical structures of the isolated compounds from the leaves of L. leucocephala were established by spectral techniques (UV, 1H, and 13C NMR, MS). Results: Chromatographic separation of 80% MeOH extract of the leaves of L. leucocephala have resulted in a novel flavonoid-galloyl glycoside [myricetin 3-O-(2′,3′4′-tri-O-galloyl)-α-l-rhamnopyranoside] with three known polyphenolic compounds isolated for the first time from this species (apigenin 7-O-β-d-glucuronopyranoside methyl ester, luteolin 7-O-β-d-glucuronopyranoside methyl ester, and 1,3,6-tri-O-galloyl-β-d-glucopyranose) and seven known previously isolated compounds. Also, 80% methanol extract exhibited high antioxidant activity (SC50u2009=u20093.94 µg/ml), which is correlated with its phenolic content. The extract also showed cytotoxic activity against Hep G2 (IC50 value 1.41 µg/ml) confirming its anticancer activity against hepatocellular carcinoma. Among the tested compounds (4–8) for antioxidant property, compound 7 was the most active compound (SC50u2009=u20092.49 µg/ml). Also compounds 7 and 8 exhibited high cytotoxic activity (IC50u2009=u20092.41 and 2.81 µg/ml, respectively). Discussion and conclusion: These findings demonstrate that the leaves of L. leucocephala contain a considerable amount of polyphenolic compounds with high antioxidant properties, thus it has great potential as a source for natural health products.


American Journal of Plant Sciences | 2011

Total Phenolic Content and Antioxidant Activity of Standardized Extracts from Leaves and Cell Cultures of Three Callistemon Species

Mohamed I. S. Abdelhady; Amira Abdel Motaal; Ludger Beerhues


Journal of Pharmacy Research | 2013

Phenolic content of Ruprechtia salicifolia leaf and its immunomodulatory, anti-inflammatory, anticancer and antibacterial activity

Eman G. Haggag; Mohamed I. S. Abdelhady; Amel M. Kamal


Polymer Journal | 2012

Polyphenolic constituents of the methanolic extract of Callistemon viridiflorous leaves and its antimicrobial activity

Mohamed I. S. Abdelhady; Amel M. Kamal; Nashwa F Tawfik; Soad M Abdelkhalik


Biosciences, Biotechnology Research Asia | 2015

Azadirachta indica as a Source for Antioxidant and Cytotoxic Polyphenolic Compounds

Ammar Bader; Mohamed I. S. Abdelhady; Usama Shaheen; Yasser El-Malah; M.A.S Abourehab; Mohamed F. Barghash


BioTechnology: An Indian Journal | 2012

Induction of callus and cell suspension cultures of three Callistemon species

Mohamed I. S. Abdelhady; Amel M. Kamal; N.F.Tawfik; S.M.Abdelkhalik; Amira Abdel Motaal; Ludger Beerhues


Bulletin of Faculty of Pharmacy, Cairo University | 2018

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits

Mohamed I. S. Abdelhady; Amel M. Kamal; Mohamed F. Barghash


Journal of Advanced Pharmacy Research | 2017

Quality Control of Herbal Products in the Egyptian Market Used for Some Gastro-Intestinal Tract Disorders

Amel M. Kamal; Eman G. Haggag; Mohamed I. S. Abdelhady; Khayrya Youssif; Amany Sleem


Biosciences, Biotechnology Research Asia | 2016

Free and conjugated polyamines in wild and transgenic types of Nicotiana tabacum calli

Mohamed I. S. Abdelhady; Amira Abdel Motaal; Rehab Kamel; Omar A. Rashwan

Collaboration


Dive into the Mohamed I. S. Abdelhady's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Ludger Beerhues

Braunschweig University of Technology

View shared research outputs
Top Co-Authors

Avatar

Ammar Bader

Umm al-Qura University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Eman A. El-Wakil

Theodor Bilharz Research Institute

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Mortada M. El-Sayed

Theodor Bilharz Research Institute

View shared research outputs
Researchain Logo
Decentralizing Knowledge