Mohamed S. El-Attar

Synthesis, characterization and antimicrobial investigation of some moxifloxacin metal complexes

The new complexes of moxifloxacin (MOX), with Ti(IV), Y(III), Pd(II) and Ce(IV) have been synthesized. These complexes were then characterized by melting point, magnetic studies and spectroscopic techniques involving infrared spectra (IR), UV-Vis, (1)H NMR. C, H, N and halogen elemental analysis and thermal behavior of complexes also investigated. The results suggested that the molar ratio for all complexes is M: MOX=1:2 where moxifloxacin acts as a bidentate via one of the oxygen atoms of the carboxylate group and through the ring carbonyl group and the complexes have the following formula [Ti(MOX)(2)](SO(4))(2)·7H(2)O, [Y(MOX)(2)Cl(2)]Cl·12H(2)O, [Pd(MOX)(2)(H(2)O)(2)]Cl(2)·6H(2)O and [Ce(MOX)(2)](SO(4))(2)·2H(2)O. The activation energies, E*, enthalpies, ΔH*, entropies, ΔS* and Gibbs free energies, ΔG*, of the thermal decomposition reactions have been derived from thermogravimetric (TGA) and differential thermogravimetric (DrTG) curves, using Coats-Redfern (CR) and Horowitz-Metzger (HM) methods. The antimicrobial activity of these complexes has been evaluated against three Gram-positive and three Gram-negative bacteria and compared with the reference drug moxifloxacin. The antibacterial activity of Ti(IV) complex is significant for E. coli K32 and highly significant for S. aureus K1, B. subtilis K22, Br. otitidis K76, P. aeruginosa SW1 and K. oxytoca K42 compared with free moxifloxacin.

Results and Indications

The aim of the present review of meniscal allograft transplantation during the last 24 years, is to put this procedure into a clinical perspective. Meniscal allograft transplantation has emerged as a useful treatment for carefully selected patients. Almost all studies, from short- to long-term (>10 years of follow-up), report patient satisfaction and improvement in pain and function. Objectively, physical examination findings are improved in the majority of patients. Radiologically, joint space narrowing is only significantly progressive at long-term follow-up. On magnetic resonance imaging (MRI), shrinkage is seen after some years, but more in lyophilized allografts. Histologically, incomplete repopulation of the graft is noticed. Second-look arthroscopy usually shows good healing to the capsule. In a recent long-term study, progression of cartilage degeneration according to MRI and radiological criteria was halted in a number of patients, indicating a chondroprotective effect. However, there still is a lack of consensus on how the success of a meniscal transplantation should be evaluated, which makes it difficult to compare study outcomes. In our opinion, radiographic measurement of joint space narrowing and changes in meniscal allograft MR signal are the best assessment tools, but the use of a good clinical evaluation system, such as the International Knee Documentation Committee (IKDC) and the Hospital for Special Surgery (HSS) scoring system, remains essential.

Complexes and Chelates of Some Bivalent and Trivalent Metals with Ciprofloxacin Schiff Base

The coordination of CIP-en (N,N′- ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-quinoline-3-carboxylic acid) towards Cr(III), Mn(II), Fe(III), Co(II), and Ni(II) ions has been investigated. The elemental analysis, melting point, molar conductivity, magnetic properties, infrared, UV-Vis, mass, 1H NMR spectra, and thermal analysis studies were used to characterize the complexes. TGA and DTG have been applied to study the compositions of the compounds. The measured molar conductance values indicate that the complexes are electrolytes in nature. The biological activities of the complexes were assayed against several bacterial strains.

Short term results of osteotomy-sparing technique in management of moderate hallux valgus using TightRope system

Background Currently, correction of the first intermetatarsal angle associated with hallux valgus is done using two main categories of surgeries either a distal or a proximal first metatarsal osteotomy. The osteotomy-sparing technique using TigthRope ®device was developed to manage hallux valgus avoiding osteotomy complications. Our hypothesis was that osteotomy sparing technique using TightRope® implant would be suitable for moderate hallux valgus in young adult patients with strong larger bones giving good results with minimal complications. Methods 26 male patients (30 feet) with age range 18-35 years (average 27.04 ± 4.6) with moderate hallux valgus deformity were managed with osteotomy-sparing method. All patients were assessed clinically using the visual analogue scale (VAS) and American Orthopedic Foot and ankle score (AOFAS) and radiological using hallux valgus angle (HVA), first inter metatarsal angle (IMA) and sesamoids position. P value <0.05 was statistically significant. Results The mean follow up time was 19.5 ± 4.1 (12-27) months. The mean IMA, HVA and AOFAS score improved from 14. 2 ± 2.8°, 33.4 ± 7.6° and 42.6 ± 6.3 points preoperatively to 8.2 ± 2.3°, 13.6 ± 5.4° and 85.8 ± 6.8 points postoperatively, respectively. All were statistically significant. Superficial infection occurred in one case and overcorrection in another with no other complications. Conclusion Osteotomy-sparing technique using TightRope device is effective in the management of moderate hallux valgus provided that proper patient selection, adequate surgical technique, and proper postoperative protocol are followed.