Mohammad Javad Taghizadeh

Synthesis of new bis-spirooxindolopyrrolizidine(pyrrolidine) derivatives via a pseudo five-component 1,3-dipolar cycloaddition reaction

A comparative study of the synthesis of new bis-spirooxindolopyrrolizidine(pyrrolidine) ring systems by the cycloaddition of azomethine ylides with a bischalcone is performed. The azomethine ylide was generated in two steps including the condensation of sarcosine or proline with isatin and decarboxylation of the produced intermediate.

Synthesis of new spiro-oxindolo-(pyrrolizidines/pyrrolidines) via cycloaddition reactions of azomethine ylides and dibenzylideneacetone

Abstract A comparative study of the synthesis of novel spiro-oxindolo(pyrrolizidine/pyrrolidine) ring systems by the cycloaddition reaction of azomethine ylides generated by a decarboxylative route from sarcosine/proline and isatin with dibenzylideneacetone using various conditions is described.Graphical abstract

Correction to: A novel strategy for the asymmetric synthesis of (S)-ketamine using (S)-tert-butanesulfinamide and 1,2-cyclohexanedione

Unfortunately, the original publication of the article contained an error in the affiliation section. The correct affiliation for author Maryam Iman should be Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Docking, Molecular Dynamics Simulation and Synthesis of New Fenobam Analogues as mGlu5 Receptor Antagonists

BACKGROUND Fenobam is a non-competitive mGluR5 antagonist as an anxiolytic agent. OBJECTIVE In this research a new series of fenobam analogues containing thiazole moiety instead of imidazole ring were designed and synthesized. METHODS The ureido-substituted products were synthesized from reaction of amino thiazole derivatives and isocyanate derivatives in dichloromethane solvent under microwave and ultrasonic irradiation condition. The synthesized compounds structures were established by means of IR, 1HNMR, 13CNMR spectroscopic data. Then, docking calculations were performed on the active site of mGLuR5 and compared to Fenobam as a reference drug by using AutoDock program. The molecular dynamics (MD) simulations were done using GROMACS 5.0.5. RESULTS Docking studies suggested that all of the compounds possess better binding energy when compared to fenobam. The results of MD simulations might offer the binding mode of ligand (3b), accuracy of docking and the reliability of active conformations which obtained by AutoDock. CONCLUSION New derivatives of fenobam were designed and synthesized that have the better insilico results compared to fenobam and will evaluate in future studies.