Mohammad Javaid Akhtar

Reaction of nitric oxide with hyponitrous acid: a hydrogen atom abstraction reaction

La reaction a lieu avec et sans inhibiteur de chaine (C 2 H 5 OH). Mesure des rendements en N 2 , N 2 O. Mecanismes

Nitrogen isotope exchange between nitric and nitrous acids

The rate of nitrogen isotrope exchange between NO−3 and NO−2 in aqueous solution has been measured, at low acidity, as a function of pH, [NO−3], [NO2−], and temperature. Exchange does not occur in the absence of NO, and during slow exchange processes NO and NO2− remain closely similar in isotopic content. The exchange rate law is shown to be R=k[H+][HNO2][NO−3], and the measured activation parameters are EA=74.4±2.6 kJ, ΔH‡=72.0±2.6 kJ, ΔS‡=−97.4±8.5 JK−1. It is concluded that there is no direct interaction pathway for nitrate–nitrite exchange, and that this process and NO–HNO3 exchange both occur via the reversible HNO2 disproportionation reaction, involving N2O4 as intermediate.

Green synthesis, inhibition studies of yeast α-glucosidase and molecular docking of pyrazolylpyridazine amines

An efficient and environmentally benign simple fusion reaction of 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (1a) or 3-chloro-6-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)pyridazine (2a) with different aliphatic/aromatic amines have produced a series of novel pyrazolylpyridazine amines (4a-4c &5a-5m). All compounds exhibited moderate in vitro yeast α-glucosidase inhibition except m-chloro derivative 5g, which was found potent inhibitor of this enzyme with IC50 value of 19.27±0.005µM. The molecular docking further helped in understanding the structure activity relationship of these compounds including 5g.