Mohammad Shah Amran

An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method

An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method Plasma protein binding is one of the most important pharmacokinetic parameter of drug. The study was designed to determine the binding of Aceclofenac and Pantoprazole to Bovine Serum Albumin. The study was conducted by equilibrium dialysis method followed by measurement using a spectrophotometer at pH 7.4 and 37°C

A Study of Prophylactic Effect Against Diabetes of Two Ayurvedic Drugs ‘Jambadyarista’ and ‘Bohumutrantak Ras’ in Normal as well as Alloxan-induced Diabetic Rats

Aims: The present study was designed to evaluate the anti -diabetic as well as prophylactic activity of Jambadyarista and Bohumutrantak Ras in alloxan -induced diabetic rats. Study Design:Study the prophylactic and antiglycemic effects against diabetes of two

Cardiovascular Activities of an Ayurvedic Preparation Amalaki Rasayan in Rat Model

The importance of traditional or alternative medicines including Ayurvedic drugs are increasing day by day because of their necessary pharmacological actions and fewer side effects. Previous investigators showed hypolipidemic and cardioprotective effects of Amla which is the active ingredient of Amalaki Rasayan. It is an ayurvedic formulation that contains extracts of Phyllanthus emblica plant. Therefore, this study has been conducted to investigate the scientific evidence of its cardioprotective effects in rats by recording electrocardiographic tracings. Rats, of either sex, were treated with preparation containing extracts of Phyllanthus emblica in doses 800 μg/kg bodyweight, 1600 μg/kg body weight and 3200 μg/kg body weight through intraperitoneal route. Electrocardiogram along with heart rate and other parameters were measuredin rat model before and after administration of Amalaki Rasayan. It was evident that Amalaki Rasayan, at a dose of 800 μg/kg, was safe but 1600 μg/kg and 3200 μg/kg produced abnormal activities in the heart. It can be inferred from the study that, the ayurvedic preparation Amalaki Rasayan possesses significant cardioprotective effect.