Mohsin Rasool

Childhood Tumors of the Brain: Demographic Pattern over a Ten-Year Period in the Kashmir Valley

Brain tumors in children represent the second most frequent tumors in this age group after hematologic malignancies. We highlight the demographic pattern after retrospective analysis of brain tumors in children from geographically and ethnically distinct Kashmir Valley managed in our center between 2000 and 2009. We had a total of 248 pediatric patients with brain tumors. The parameters analyzed were age, gender, location of tumors and histopathological subtypes as well as WHO grade of tumor. We also did a comparison between the frequencies of common varieties of tumor in the first and second 5-year periods. We found that 111 tumors (44.75%) were supratentorial, and 137 (55.25%) were infratentorial. The male-to-female ratio was 1.4:1. The proportions of low-grade and high-grade tumors were 60 and 40%, respectively. The most common tumor in our series was astrocytoma. The most common tumors in the supratentorial and infratentorial compartments were craniopharyngioma and medulloblastoma, respectively. Our experience reflects a different demographic profile of pediatric brain tumors as compared with other regions of the world.

Coexistent Papillary Carcinoma of Thyroid and Hashimoto's Thyroiditis - Diagnosis on Fine Needle Aspiration Cytology

Hashimoto’s thyroiditis is associated with an increased risk of developing papillary carcinoma of thyroid. We hereby report a case of Hashimoto’s thyroiditis with papillary carcinoma in a 45-year-old ear old female diagnosed on fine needle aspiration cytology (FNAC) which was later confirmed on histopathological examination .Such an occurrence, when both lesions are picked up on FNAC in a patient with no palpable thyroid nodule is rare. The case is presented here for its rarity.

Fibrous Pseudotumor of Paratestis Mimicking a Testicular Tumor

Fibrous pseudotumor is a rare entity involving the paratestis comprising about 6%. These lesions are considered to represent a benign reactive process that chiefly affect young adults and mimic testicular tumors. We report a case of a 35 year old male who presented with a painless testicular mass since 2 year. This case is reported due to its extreme rarity and highlights the need to incorporate this rare tumor as a differential diagnosis in young adults with testicular mass.

Synchronous Primary Adenocarcinoma and Gastrointestinal Stromal Tumor of Stomach: A Case Report and Review of Literature

A synchronous occurrence of epithelial and gastrointestinal stromal tumors (GISTs) in the stomach is unusual. The association has often been detected incidentally and it is not known whether such an association is a simple incidental coexistence or there is a causal relationship between the two lesions. We hereby report a 70-year-old male operated for adenocarcinoma of stomach who, besides the primary lesion in the lesser curve, had another lesion i.e., GIST on the serosal aspect of antrum picked up on gross examination of the specimen. The tumor was GIST of low risk category which was positive for tumor markers CD117 (C-kit) and CD34. The case is presented here for its rarity.

Squamous Cell Carcinoma of Lung with Osteo-Cartilaginous Metaplasia: A Case Report and Review of the Literature

Abstract Calcification and ossification are very rare in primary squamous cell carcinoma of the lung. We report a 55-year-old male with primary squamous cell carcinoma of the lung who on histopathological examination was seen to have extensive calcification and ossification. Squamous carcinoma of the lung rarely presents with osteocartilaginous metaplasia. The case is presented here for its unique presentation. ÖZ Akciğerin primer skuamöz hücreli karsinomunda kalsifikasyon ve ossifikasyon çok nadirdir. Histopatolojik incelemede yaygın kalsifikasyon ve ossifikasyon görülen primer skuamöz hücreli akciğer karsinomu bulunan 55 yaşında bir erkek hastayı sunuyoruz. Akciğerin skuamöz hücreli karsinomu nadiren osteokartilajinöz metaplazi gösterir. Vaka bu nadir özelliği nedeniyle sunulmuştur.

Primary Angiosarcoma of the Brain in a Teenager: A Rare Entity

Angiosarcoma is a rare malignant neoplasm of vascular endothelium that occurs mainly in the skin and soft tissues. Its origin from the central or peripheral nervous system has been rarely documented. These tumors may occur at any age, with age ranging from 2 weeks to 72 years. It is, however, rare in children. We report case of a 13-year-old girl, who presented with headache and vomiting. She had minimal neurodeficits. Imaging revealed a right frontoparietal peripherally enhancing mass lesion for which she underwent a surgery. Biopsy of the lesion showed angiosarcoma. She was also given an adjuvant therapy. Angiosarcoma of the brain should be considered as a possibility in enhancing mass lesions with flow voids. During surgery, blood loss and air embolism are a major concern. The prognosis is poor considering the malignant nature of the tumor.

Cyto-histopathological and clinical correlation of pilomatricomas: A 4 year study

Aim: The aim of the following study is to characterize the cytological features of pilomatricomas (PMXs) on fine-needle aspiration (FNA) and correlate with the histopathological features. Materials and Methods: FNA, histopathological and clinical diagnosis of 12 cases of PMXs were analyzed. Clinical, aspiration findings and histopathological features were correlated with histopathological diagnosis which was taken as the gold standard. A written consent was taken from patients or parents as appropriate. Morphological features of both aspiration as well as histopathological features were graded. The study was duly approved by the Hospital Scientific Review Committee. Results: Out of the 7600 cases studied retrospectively over a period of 4 years, only 12 cases were diagnosed as PMXs. These tumors were mainly located in the head and neck region and mostly affected young females (median age 9.5 years). The mean size of these lesions was 0.9 cm. Out of the 12 histopathologically proven cases of PMX, the correct clinical diagnosis was given in only one case while cytopathological diagnosis was achieved in four cases. Conclusion: PMX is a rare tumor, which is mostly found in the pediatric age group. The clinical features should be keenly observed. Keeping in mind the diagnostic pitfalls a cytopathologist may encounter, histopathology should be regarded as the gold standard for diagnosis.

Central Nervous System Tuberculosis-Clinicopathologic Characteristics

Tuberculosis is a chronic granulomatous infection occurring due to Mycobacterium tuberculosis, a slow growing, gram-positive rod, which is resistant to acid decoloration when stained with aniline dyes. Tuberculosis is endemic in developing countries, but even in the developed countries after an initial decline up to 1980s, the incidence of tuberculosis is on the rise. Central nervous system (CNS) tuberculosis is a serious, often fatal disease predominantly affecting young children. The CNS involvement comprises approximately 10% to 15% of all tuberculosis infections. Granulomatous inflammatory reaction in CNS caused by Mycobacterium tuberculosis may involve the meninges, brain, spinal cord, and the bones covering the brain and spinal cord, and may manifest clinically as tubercular meningitis, tuberculomas in brain, tubercular brain abscess, tuberculous encephalopathy, spinal tuberculosis and tuberculomas. This review focuses on the various patterns of CNS tuberculosis and various modalities used for the diagnosis.