Moidin Shakil

Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis

Context: Local drug delivery (LDD) systems have been proposed for the treatment of periodontitis. Curcumin could be a suitable agent as LDD for the treatment of periodontitis. Aim: To formulate, evaluate the anti-inflammatory activity and to assess the duration of the action and the efficacy of 2% curcumin gel in the treatment of experimental periodontitis in Wistar albino rat model. Settings and Design: Twenty-one Wistar albino rats were randomly assigned to three groups. Periodontitis was induced using ligature model. Group 1: Control; group 2: Plain gel, and group 3: 2% curcumin gel. Materials and Methods: About 2% curcumin gel was prepared. The anti-inflammatory activity and duration of action was assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI) and probing pocket depth (PPD) were measured. Treatment was done. The rats were sacrificed. Morphometric analysis was performed using stereomicroscope and ImageJ software. Statistical Analysis Used: Analysis of variance followed by Bonferronis test, Wilcoxons test for inter-group comparison, Mann–Whitney test for P value computation was used. The observations are mean ± standard deviation and standard error of the mean. P < 0.01 when compared to control was considered as statistically significant. Results: About 2% curcumin gel showed 42.98% inhibition of edema and peak activity was noted at 24 h. There was statistically significant change in the GI and PPD. Morphometric analysis did not show any significant difference between groups. No toxic effects were seen on oral administration of 2000 mg/kg of curcumin. Conclusions: About 2% curcumin gel was effective in the treatment of experimental periodontitis.

Quick response code in Oral and Maxillofacial Radiology

Quick response (QR) codes are two-dimensional barcodes that are used to encode and decode information. QR code is an innovative approach in which patient details and radiographic interpretation can be encoded. These QR codes can be shared efficiently worldwide with easy authentication. QR code is a boost to early diagnosis and retrospective studies. Implementing QR code in Oral and Maxillofacial Radiology will save time, eliminate paper work, and problems encountered in storage of patient details with radiographic interpretation and minimize manual efforts in retrieval of information.

Histopathological, immunohistochemical and special stain unraveling the enigmatic carcinosarcoma--A case report.

Carcinosarcoma is an extremely rare, highly malignant tumor having a characteristic of both epithelial and mesenchymal components; the epithelial component exhibiting focal squamous cell carcinoma and mesenchymal component having sarcomatoid stroma. The occurrence of carcinosarcoma in the oral cavity is very rare and only few cases have been reported in the literature, although its occurrence in other parts of the body has been widely reported.

Evaluation of the efficacy of 2% Ocimum sanctum gel in the treatment of experimental periodontitis.

Introduction: One of the options for the treatment of periodontitis is local drug delivery systems (LDD). Tulsi (Ocimum sanctum), a traditional herb, has many uses in medicine. It could be a suitable agent as LDD for the treatment of periodontitis. Aim: The aim was to formulate, evaluate the anti-inflammatory activity; assess duration of the action and the efficacy of 2% tulsi (O. sanctum) gel in the treatment of experimental periodontitis in Wistar Albino rat model. Settings and Design: Thirty six Wistar albino rats were randomly assigned to 3 groups. Periodontitis was induced using ligature model. Group 1-control; Group 2-Plain gel and Group 3-2% tulsi (O. sanctum) gel. Materials and Methods: 2% tulsi (O. sanctum) gel were prepared. The anti-inflammatory activity and duration of action were assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI) and probing pocket depth were measured. Treatment was done. The rats were sacrificed. Morphometric analysis was done using Stereomicroscope and ImageJ software. Statistical Analysis Used: ANOVA followed by Bonferronis test, Wilcoxons test for intergroup comparison, Mann-Whitney test for P value computation was used. The observations are mean ± standard deviation and standard error of the mean. P < 0.01 as compared to control was considered as statistically significant. Results: 2% tulsi (O. sanctum) gel showed 33.66% inhibition of edema and peak activity was noted at 24 h. There was statistically significant change in the GI and probing pocket depth. Morphometric analysis did not show any significant difference between groups. No toxic effects were seen on oral administration of 2000 mg/kg of Tulsi extract. Conclusions: 2% tulsi (O. sanctum) gel was effective in the treatment of experimental periodontitis.

Quick response codes in Orthodontics

Quick response (QR code) codes are two-dimensional barcodes, which encodes for a large amount of information. QR codes in Orthodontics are an innovative approach in which patient details, radiographic interpretation, and treatment plan can be encoded. Implementing QR code in Orthodontics will save time, reduces paperwork, and minimizes manual efforts in storage and retrieval of patient information during subsequent stages of treatment.

Liposarcoma of the maxillary antrum: A case report

Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma. (ALT/WDL) is a soft tissue sarcoma of intermediate malignant behavior, which most frequently affects the retroperitoneum and lower extremities. Liposarcomas of head and neck are rare, representing only 2-8% of all sarcomas in this region. The majority of liposarcomas occur in middle-aged adults; however, very uncommonly cases have been reported in infancy and early childhood. We report a case of a 14-year-old girl diagnosed as ALT/WDL of the maxillary antrum.

Pyogenic Granuloma of Oral Cavity: a Case Report

Pyogenic granuloma is a common inflammatory hyperplasia of the oral cavity, which is composed of granulation tissue and develops in response to local irritation or trauma. Females are more affected than men due to the hormonal effects on vasculature that occur during puberty, pregnancy and menopause. We report a case of large pyogenic granuloma in an adult male patient extending from maxillary anteriors upto the 2nd molar.

Fusion of deciduous central incisors

Fusion is a common dental anomaly affecting both primary as well permanent dentitions. Fusion is the union between two normally separated tooth germs. The problems associated with fused teeth are esthetics, arch symmetry, spacing, and malocclusion. These problems require cosmetic and orthodontic consideration.

Peripheral Giant Cell Granuloma from Dentist's Perspective - A Case Report & Review

Peripheral giant cell granuloma(PGCG) is considered to be a benign hyperplastic reactive lesion. Though etiology is unclear, it appears to be caused by local irritation or chronic trauma. This article presents a case of PGCG in a 68 year old female, with an emphasis on the need for awareness among general practioners regarding the role of dentists in adequate management to help in the prevention of recurrence of this lesion. Other less common features of peripheral giant cell granuloma which were present in our case, like the presence of calcification in the lesion, large size of the lesion and the possibility of a multiple peripheral giant cell granuloma without any concomitant systemic disease have been reviewed here.