Mong-Shang Lin
Medical College of Wisconsin
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Publication
Featured researches published by Mong-Shang Lin.
Journal of Translational Medicine | 2004
Alberta Lucchese; Abraham Mittelman; Mong-Shang Lin; Darja Kanduc; Animesh A. Sinha
BackgroundWalking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim, we are studying the targets of the immune response in autoimmune diseases by applying the principle of non-self-discrimination as a driving concept in the identification of the autoimmunogenic peptide sequences.MethodsComputer-assisted proteomic analysis of the autoantigen protein sequence and dot-blot/NMR immunoassays are applied to the prediction and subsequent validation of the epitopic sequences.ResultsUsing the experimental model Pemphigus vulgaris/desmoglein 3, we have identified the antigenic linear determinant recognized by MAb 5H10, a monoclonal antibody raised against the extracellular domain of human desmoglein-3. The computer-assisted search for the Dsg3 epitope was conducted by analyzing the similarity level to the mouse proteome of the human desmoglein protein sequence. Dot-blot immunoassay analyses mapped the epitope within the sequence Dsg349–60 REWVKFAKPCRE, which shows low similarity to the mouse proteome. NMR spectroscopy analyses confirmed the specificity of MAb 5H10 for the predicted epitope.ConclusionsThis report promotes the concept that low level of sequence similarity to the hosts proteome may modulate peptide epitopicity.
Journal of Investigative Dermatology | 2003
Simon Warren; Luis A. Arteaga; Luis A. Diaz; Evandro A. Rivitti; Valeria Aoki; Gunter Hans-Filho; Bahjat F. Qaqish; Mong-Shang Lin; George J. Giudice
Clinical Immunology | 2002
Mary K. Hacker; Marleen M. Janson; Janet A. Fairley; Mong-Shang Lin
Clinical Immunology | 2005
Valerie K. Salato; Mary K. Hacker-Foegen; Zelmira Lazarova; Janet A. Fairley; Mong-Shang Lin
Clinical Immunology | 2006
Shih-Wei Yeh; Lisa A. Cavacini; Kailash C. Bhol; Mong-Shang Lin; Mukesh Kumar; Mark Duval; Marshall R. Posner; A. Razzaque Ahmed
Clinical Immunology | 2002
Mong-Shang Lin; Chang-Ling Fu; Monica Olague-Marchan; Mary K. Hacker; Detlef Zillikens; George J. Giudice; Janet A. Fairley
Journal of Investigative Dermatology | 2003
Mary K. Hacker-Foegen; Janet A. Fairley; Mong-Shang Lin
Clinical Immunology | 2004
Mary K. Hacker-Foegen; Detlef Zillikens; George J. Giudice; Mong-Shang Lin
Journal of Experimental Therapeutics and Oncology | 2005
Gianni D. Angelini; Domenico Bonamonte; Mong-Shang Lin; Alberta Lucchese; Abraham Mittelman; Rosario Serpico; Simone S; Animesh A. Sinha; Darja Kanduc
Journal of Dermatological Science | 1998
Mong-Shang Lin; Susan J. Swartz; Manish Gharia; Janet A. Fairley; George J. Giudice; Luis A. Diaz