Mónica Gutiérrez López

Aging and lung antioxidant enzymes, glutathione, and the lipid peroxidation in the rat

The five major antioxidants enzymes, cytochrome oxidase (COX), GSH, and GSSG, and endogenous and in vitro stimulated lipid peroxidation (TBA-RS) were assayed in the lung of old (28 months) and young (9 months) adult rats due to the almost total absence of data of this kind in this tissue, which is normally exposed to relatively high pO2 throughout life. Catalase, selenium (Se)-dependent GSH peroxidase (GPx), GSH reductase, GSH, GSSG, GSSG/GSH, and in vivo and in vitro TBA-RS showed similar values in old and young animals. The decrease observed for non Se-dependent GPx disappeared when the values were expressed in relation to COX activity. Only superoxide dismutase showed a clear decrease when referred both to protein and COX activity. These results suggest that lung aging is not accelerated in old age due to a decrease in the antioxidant capacity of the tissue. Nevertheless, they are compatible with a continuous damage of the lung tissue by free radicals throughout the life span.

Arabia Terra, Mars: tectonic and palaeoclimatic evolution of a remarkable sector of martian lithosphere

A regional geologic study of Arabia Terra, a densely cratered area of Mars northern hemisphere, has revealed the individuality of this province. This is best expressed by an equatorial belt with a crater age distinctly younger as compared to the northern part of Arabia Terra and to Noachis Terra to the south. We interpret this as an incipient back-arc system provoked by the subduction of Mars lowlands under Arabia Terra during Noachian times. The regional fracture patterns are also best explained in this manner, making it unnecessary to appeal to a rotational instability of the planet, which is not supported by the palaeoclimatic indicators in the area. This model could be the first regional-scale confirmation of Sleeps (1994) hypothesis of a limited plate consumption as an explanation of the martian dichotomy.