Monica Haglund
Malmö University
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Publication
Featured researches published by Monica Haglund.
Acta Oncologica | 2009
Lisa Rydén; Monica Haglund; Pär-Ola Bendahl; Thomas Hatschek; Aleksandra Kolaric; Anikó Kovács; Ann Olsson; Hans Olsson; Carina Strand; Mårten Fernö
Background. HER2 is a treatment predictive factor for the effect of trastuzumab and associated with poor prognosis in breast cancer. The analysis of HER2 must be performed with good quality, with regard to both the immunohistochemical (IHC) and in situ hybridization (ISH) analysis. Material and methods. A tissue microarray (TMA) including 11 breast cancer samples was sent twice (once in 2005 and again in 2006) to 24 pathology departments in Sweden. A questionnaire was also sent to the departments in 2006. Results. With IHC, all departments reported the same results (0/1+ vs. 2+ vs. 3 + ) for three (2005) and six samples (2006). The mean kappa-value increased from 0.67 to 0.77, indicating a good reproducibility at both occasions. With fluorescence-ISH (FISH), the 11 departments using this technique reported the same results (amplified vs. normal) for nine (2005) and ten samples (2006). The mean kappa-value showed very good reproducibility both 2005 and 2006 (0.92 and 0.96, respectively). Based on the answers from the participating departments, the questionnaire revealed that 31% of primary breast cancer diagnosed in 2006 (n = 5 043) were 2 + /3+. FISH analysis of 2+ confirmed 12% of the samples to be amplified. The corresponding figure for 3 + was 90%. In total, 14.3% of the samples were HER2 positive (2+ and amplified, or 3 + ). Discussion. The results obtained in this study indicate that the reproducibility for HER2 analysis is good (IHC) and very good (FISH) between the pathology departments in Sweden using TMA-based tumor samples. In 2006, 14.3% of invasive breast cancers were HER2 positive.
International Journal of Cancer | 2008
Roy Ehrnström; Lars Magnus Bjursten; Otto Ljungberg; Béla Veress; Monica Haglund; Clas G. Lindström; Tommy Andersson
Dietary factors play essential roles in gastric carcinogenesis. We recently found that dietary supplementation with NaHCO3 significantly increased the development of gastric cancer in a rat gastric stump model. Here, we analysed nontransformed gastric mucosa for expression of the cancer‐related proteins cyclooxygenase‐2 (COX‐2) and ornithine decarboxylase (ODC), and we examined the relationship between expression levels of those proteins and mucosal proliferation. Research has shown that COX‐2 is upregulated in gastric mucosal inflammation and is strongly associated with gastrointestinal cancer. ODC is the key enzyme in polyamine synthesis and a regulator of cell proliferation. We performed gastric resections on 48 Wistar rats to induce spontaneous gastric cancer; half of these animals were given a normal diet, and the other half received a diet supplemented with NaHCO3. Twenty‐four unoperated rats served as a control group. The surgical procedure per se led to a significant rise in mucosal expression of COX‐2 and an associated increase in cell proliferation. However, the COX‐2 level in gastric mucosa was not further affected by dietary supplementation of carbonate. Interestingly, nontransformed gastric mucosa in the operated rats receiving a carbonate‐supplemented diet showed a pronounced increase in ODC expression that was strongly correlated with a further enhanced cell proliferation. These results indicate that carbonate ions, which represent a major constituent of intestinal reflux into the stomach, increase the expression of ODC and thereby enhance cell proliferation in nontransformed mucosa, and consequently elevate the risk of gastric cancer.
Breast Cancer Research and Treatment | 2010
Lisa Rydén; Karin Jirström; Monica Haglund; Olle Stål; Mårten Fernö
Gastroenterology | 2007
Bodil Ohlsson; Béla Veress; Sabina Janciauskiene; Agneta Montgomery; Monica Haglund; Anders Wallmark
Virchows Archiv | 2013
Sofi Isaksson; Pär-Ola Bendahl; Annette Salomonsson; Mats Jönsson; Monica Haglund; Alexander Gaber; Karin Jirström; Per Jönsson; Åke Borg; Leif Johansson; Johan Staaf; Maria Planck
Läkartidningen | 2008
Mårten Fernö; Monica Haglund; Pär-Ola Bendahl; Hans Olsson; Lisa Rydén
Virchows Archiv | 2008
Jens Enoksson; Monica Haglund; Maria Planck; Per Jönsson; Karin Jirström; Leif Johansson
Journal of Thoracic Oncology | 2007
Jens Enoksson; Monica Haglund; Karin Jirström; Per Jönsson; Maria Planck; Leif Johansson
The Journal of Swedish Medical Association; 102(10), pp 740-743 (2005) | 2005
Monica Haglund; G Chebil; Leif Johansson
Läkartidningen | 2005
Monica Haglund; Chebil G; Leif Johansson