Monica Sharma

Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsychotic as well as anticonvulsant activity.

Evaluation of cardioprotective effect of Aegle marmelos on doxorubicin induced cardiotoxicity: an experimental study

Cardiovascular diseases (CVD’s) have now become the leading cause of mortality in India. A quarter of all mortality is attributed to CVD. Ischemic heart diseases and stroke are the predominant causes and are responsible for >80% of CVD deaths. The most successful treatment for acute myocardial infarction is reperfusion by early thrombolytic therapy or primary percutaneous coronary intervention (PCI), although early reperfusion can also induce injury termed as reperfusion injury. The heart can be protected against ischemia-reperfusion injury with both endogenous activation and pharmacological treatment. Pharmacological protection means that one can add a compound to the body which can protect an organ directly or by the activation of endogenous protective systems/pathways. Many agents from modern therapeutic armamentarium have been investigated for their potential to afford cardiac protection. But these agents have not been able to come up with a satisfactory answer, against the menace of cardio toxicity caused by drugs which are essentially prescribed for malignancies and other ailments. Doxorubicin induced cardiotoxicity is a well-established standard model to study the beneficial effect of many drugs ABSTRACT

Cardioprotective effect of Solanum nigrum against doxorubicin induced cardiotoxicity-an experimental study

Background: Solanum nigrum (S.nigrum) a medicinal herb is widely used in the Indian system of medicine for treatment of various ailments. The methanolic extract of S.nigrum berries had shown cardio protective and antioxidant effect. However, so far aqueous extract of S.nigrum is not scientifically evaluated for its cardio protective potential. Hence the present study was designed to find out cardio protective role of S.nigrum against doxorubicin induced cardiotoxicity. Methods: Seventy two rats were randomized into four major groups (n=6). group I received 2 ml/100 g/day normal saline p.o daily, group II received 2 ml/100 g/day of normal saline p.o daily, group III received carvedilol 30 mg/kg/day p.o daily and group IV received S.nigrum 1 g/kg/day p.o daily for test durations of 20, 30 and 40 days respectively. Doxorubicin 20 mg/kg i.p single dose was given to induce cardiotoxicity in rats of group II, III and IV respectively on last day of each experiment. Animals were sacrificed 48 hours after doxorubicin administration. Cardiac serum markers creatinine phosphokinase MB, lactate dehydrogenase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase were analysed biochemically. Histopathological changes were studied under light microscope. Results: All cardiac serum marker levels were found significantly (p<0.001) increased in doxorubicin group while S.nigrum pretreated group displayed significant (p<0.001) reduction in rise of these parameters in a time dependent manner indicating cardio protection. Histological observations further correlated the cardio protective effect of S.nigrum. Conclusions: The present study concluded that aqueous extract of S.nigrum possess cardio protective potential against doxorubicin induced cardiotoxicity.

Evaluation of nephroprotective and nephrocurative activity of Solanum nigrum on gentamicin induced nephrotoxicity in experimental rats

Background: Aminoglycoside antibiotics are most commonly used drugs for the prevention and treatment of gram negative infections. Nephrotoxicity is the main side effect that restricts its long duration use. Modern medicines to treat nephrotoxicity are costly and also not vary effective. Solanum nigrum fruits, having potent antioxidant property can be used for nephroprotection as well as nephrocure. Methods: The study was carried out in two phases. Nephroprotective phase, 54 rats were randomized in 3 groups named G10, G20 & G30 according to 10, 20 & 30 days of treatment. Each group was randomized in three subgroups i.e. control C group [received normal saline (2 ml/100 gm/day) daily for test duration], GT group [received normal saline (2 ml/100 gm/day) daily for test duration & intra-peritoneal gentamicin (40mg/kg) for last five days] & SNT group [received orally S.nigrum (200 mg/kg/day) daily for the test duration and intra-peritoneal gentamicin (40 mg/kg) for last five days]. Rats were sacrificed 24 hours after the last dose of gentamicin (on 11 th , 21 st and 31 st day). In nephrocurative phase, 72 rats were randomised in two groups of 36 rats each. Group-1 received intra-peritoneal gentamicin (40 mg/dl) for five days. Group-2 received intra-peritoneal gentamicin (40 mg/dl) for five days and then S.nigrum (200 mg/kg/day) orally till the rats are sacrificed. Six rats from each group were sacrificed on 3 rd , 5 th , 7 th , 10 th , 12 th and 14 th day after administration of last dose of gentamicin. Blood sample were taken for evaluation of BUN and serum creatinine. Results: There was significant decrease in BUN and serum creatinine values as compared to GT group in all test duration in phase-1. In phase two there was no significant difference of these markers in two groups. Conclusions: S.nigrum fruits extract provide nephroprotection against gentamicin induced nephrotoxicity.