Montserrat Vallverdú Ferrer

Interaction between EEG and drug concentration to predict response to noxious stimulation during sedation-analgesia: effect of the A118G genetic polymorphism.

The level of sedation in patients undergoing medical procedures is affected by the interaction between the effect of the anesthetic and analgesic agents and the pain stimuli. The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene affects the requirements of opioids for patients undergoing sedation-analgesia. The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 on EEG measures for the prediction of the response to pain stimulation during endoscopy procedure. The proposed measures were based on power spectral density and auto-mutual information function. It was found that the statistical performances of the EEG measures improved when the presence of the SNP was taken into account (prediction probability Pk>0.9).

Methods in brain connectivity. Inference through multivariate time series analysis. Koichi Sameshima, Luiz Antonio Baccalá. Frontiers in neuroengineering. Boca Raton, FL, USA: CRC Press, Taylor & Francis Group [ISBN 978-1-43984-5721].

This book makes an enjoyable reading for those that use some form of brain connectivity for their clinical or research work, but also this book may be very helpful for researchers interested in starting work in the field of brain connectivity.