Morag A. Grassie

The Use of Stably Transfected Cell Lines in the Analysis of Functional Interactions between Goα1 & Giα2 and the α2C10 Adrenoceptor

Heterotrimeric guanine nucleotide-binding proteins (G-proteins) play a central role in the transmission of information inside the cell from extracellular signals. The signal crosses the plasma membrane via serpentine receptors resulting in the activation of heterotrimeric G-proteins which can then in turn interact with a number of effector systems. Both heterotrimeric G-proteins and G-protein-linked receptors exist as large multi-member families. Therefore the specificity of G-protein-receptor interaction is clearly very important as depending on which G-protein the receptor couples to, a different effector system can activated.