Moritoshi Funasako
Kumamoto University
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Featured researches published by Moritoshi Funasako.
Circulation | 2016
Moritoshi Funasako; Takeshi Aiba; Kohei Ishibashi; Ikutaro Nakajima; Koji Miyamoto; Yuko Inoue; Hideo Okamura; Takashi Noda; Shiro Kamakura; Toshihisa Anzai; Teruo Noguchi; Satoshi Yasuda; Yoshihiro Miyamoto; Kengo Kusano; Hisao Ogawa; Wataru Shimizu
BACKGROUND Mexiletine is often used for medical therapy in LQT3 patients, however, the usefulness of mexiletine infusion test for LQT3 patients has not been reported. The aim of this study was to evaluate the usefulness of mexiletine infusion test for detecting LQT3 patients. METHODSANDRESULTS We analyzed response in 12-lead electrocardiogram parameters measured in II or V5 to i.v. mexiletine infusion (2 mg/kg) during sinus rhythm among 31 genotype-positive LQT patients (29 ± 18 years, 12 male). Change in QTc interval after mexiletine was compared between LQT3 (n=15, 24 ± 21 years, 9 male) and other LQT patients (4 LQT1 and 12 LQT2; 34 ± 14 years, 3 male). Baseline RR, QT, and QTc interval were not different between the 2 groups (981 ± 182 vs. 1,023 ± 192 ms; 550 ± 94 vs. 524 ± 75 ms; 556 ± 66 vs. 520 ± 62 ms, respectively). While QTc interval was shortened with mexiletine in both groups (P<0.0001 vs. baseline), degree of QTc shortening (∆QTc) was significantly larger in LQT3 than in LQT1/LQT2 patients (99 ± 39 vs. 48 ± 32 ms; P=0.0004). The sensitivity, specificity and predictive accuracy of mexiletine infusion test for differentiating LQT3 from LQT1/LQT2 were 86.7%, 81.3% and 81.3%, respectively, and the optimal cut-off for ∆QTc was 69 ms on receiver operating characteristic analysis. No pro-arrhythmic event was observed. CONCLUSIONS Pronounced shortening of QT interval with mexiletine may facilitate genetic testing in patients with LQT3 syndrome.
Journal of the American College of Cardiology | 2015
Eisaku Nakane; Nozomi Tanaka; Yuki Kimura; Takayuki Sekihara; Hideyuki Hayashi; Mitsumasa Okano; Kanae Su; Masahiro Kimura; Moritoshi Funasako; Takao Kato; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Moriaki Inoko
The number of elderly patients with decompensated heart failure (HF) is increasing. We investigated the relation between hospital readmission and elderly people with HF who were living alone or living only with an elderly spouse and who were thought to have difficulty with self-care, such as fluid
Journal of Cardiology Cases | 2012
Moritoshi Funasako; Akira Funada; Hideaki Kanzaki; Hiroyuki Takahama; Makoto Amaki; Takuya Hasegawa; Yoshihiko Ikeda; Hatsue Ishibashi-Ueda; Toshihisa Anzai; Masafumi Kitakaze
We report a case of eosinophilic endomyocarditis caused by eosinophilia due to dobutamine allergy and successfully treated by a short-term and medium-dose steroid administration. Serial endomyocardial biopsies were useful for early diagnosis and evaluation of the effect of the treatment. Eosinophilic endomyocarditis due to dobutamine allergy is a rare entity; however, because of the high utilization rate of dobutamine in patients with low output heart failure, it is important to recognize that additional deterioration of cardiac function caused by eosinophilic endomyocarditis makes prognosis poor and early intervention is necessary. <Learning objective: Eosinophilic endomyocarditis due to dobutamine allergy is a rare entity; however, because of the high utilization rate of dobutamine in patients with low output heart failure, it is important to recognize that additional deterioration of cardiac function caused by eosinophilic endomyocarditis makes their prognosis poor and early intervention is necessary. Serial endomyocardial biopsies were useful for early diagnosis and evaluation of the effect of the treatment.>.
Internal Medicine | 2018
Hideyuki Hayashi; Masahiro Kimura; Takao Kato; Kazutaka Nakasone; Yuta Seko; Takayuki Sekihara; Yuki Kimura; Moritoshi Funasako; Kenichi Sasaki; Eisaku Nakane; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Moriaki Inoko
Recently, it has been reported that spontaneous left ventricular wall thickening occurs among patients with takotsubo syndrome, which affects the long-term prognosis of such patients due to cerebral and cardiac complications. We herein report two cases of transient left ventricular wall thickening with takotsubo syndrome in which sequential cardiac magnetic resonance imaging revealed the existence of edematous changes in the thickened wall. Notably, a left ventricular aneurysm was detected during the course of ventricular wall thickening and may have played a role in the development of serious complications accompanied by takotsubo syndrome. This is the first case report of left ventricular aneurysm occurring with ventricular wall thickening due to takotsubo syndrome.
Internal Medicine | 2016
Takayuki Sekihara; Masahiro Kimura; Daisuke Hazama; Yuki Kimura; Hideyuki Hayashi; Mitsumasa Okano; Moritoshi Funasako; Kenichi Sasaki; Eisaku Nakane; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Motonari Fukui; Moriaki Inoko
Platypnea-orthodeoxia syndrome (POS) is a rare condition characterized by interatrial right-to-left shunting that is exacerbated in the upright position. We herein report a 78-year-old woman with POS that remained undiagnosed for 2 years, despite repetitive transthoracic echocardiography (TTE). POS was ultimately diagnosed using contrast transesophageal echocardiography (TEE), which revealed a marked increase in right-to-left shunting in the sitting position, associated with simultaneous desaturation. Therefore, we propose that POS should be considered according to the clinical symptoms, regardless of the repetitive TTE results, and contrast TEE should be performed in both the supine and sitting positions to exclude a diagnosis of POS.
Journal of Cardiac Failure | 2016
Yuki Kimura; Chikako Aga; Hideyuki Hayashi; Moritoshi Funasako; Kenichi Sasaki; Eisaku Nakane; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Moriaki Inoko
Nihon Naika Gakkai Zasshi | 2015
Moriaki Inoko; Yuki Kimura; Moritoshi Funasako; Kentaro Tatsuno; Kenichi Komatsu; Naomi Matsuzaki; Taka-aki Matsuyama
Journal of Cardiac Failure | 2015
Takayuki Sekihara; Takao Kato; Moritoshi Funasako; Kenichi Sasaki; Eisaku Nakane; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Moriaki Inoko
Circulation | 2014
Shoichi Miyamoto; Toshiaki Izumi; Eisaku Nakane; Takao Katoh; Moritoshi Funasako; Masahiro Kimura; Kanae Su; Mitsumasa Okano; Yuki Kimura; Takayuki Sekihara; Hideyuki Hayashi; Jun Iida; Manabu Morishima; Koji Ueyama; Tetsuya Haruna; Masatoshi Fujita; Moriaki Inoko
Circulation | 2014
Yusuke Morita; Takao Kato; Moritoshi Funasako; Eisaku Nakane; Shoichi Miyamoto; Toshiaki Izumi; Tetsuya Haruna; Moriaki Inoko