Morton D. Bogdonoff

The Association of Nocturnal Angina Pectoris with Dreaming

Excerpt The value of a restful sleep at night has been repeatedly stressed in the care of the patient with angina pectoris. However, some individuals with the anginal syndrome are aroused at night ...

Acute effect of psychologic stimuli upon plasma non-esterified fatty acid level.

Summary 1. Serum non-esterified fatty acids (NEFA) and triglyceride (TG) levels were measured in four normal individuals during difficult levels of emotional arousal. 2. Periods of arousal in which feelings of anxiety and/or hostility were evoked were accompanied by rises in serum NEFA levels, but not of TG levels.

Fat Mobilization in Man.

Excerpt The process of fat mobilization has become accessible to study in man with the recognition that the albumin-bound nonesterified or free fatty acids are the major form of transport of lipid ...

The impact of illness upon the spouse

Abstract One hundred and twenty-one patients with chronic illness and 73 spouses of the patients were studied at the time of their application to the medical outpatient clinic of a University Medical Center. Levels of symptomatology, interpersonal tension and work activity were found to be significantly altered from pre-illness levels in both patients and spouses at the start of evaluation and treatment. There was a significant correlation between symptom levels and role tension levels in patients and spouses. The findings are interpreted in terms of the impact of illness upon intrafamily relationships.

The Physiologic Response to Conformity Pressure in Man

Excerpt Experiments conducted in our laboratory and in those of others have demonstrated that many emotional stimuli cause marked changes in the body. These changes are most likely to result in sym...

Effect of Phentolamine (Regitine®) on Human Plasma FFA in vivo.

Summary 1) Nine human subjects were given phentolamine (Regitine®) infusions to observe the effect upon plasma FFA levels. 2) There was a consistent abrupt rise in venous FFA levels ranging from 100-500 μm/l without blood glucose changes. FFA values remained higher 1 hour after infusion. 3) The mechanism of this phentolamine effect on lipid metabolism is not known. We thank Dr. William E. Wagner, Ciba Pharmaceutical Products, Inc., for generous supply of Regitine® used.

THE EFFECT OF 2-DEOXY-D-GLUCOSE INFUSIONS ON LIPID AND CARBOHYDRATE METABOLISM IN MAN

At the present time, the direction of change of the plasma free fatty acid (FFA) level is considered to serve as an index to the pattern of fat metabolism, representing an indicator of the balance between fat storage and fat mobilization. In the fasting, nonexercising individual, a rising plasma FFA level suggests net fat mobilization and a falling FFA level suggests net fat storage. If the status of carbohydrate metabolism does relate to fat metabolism, then plasma FFA levels may be expected to change in a number of experimental situations. Dole Was the first to (lemonstrate that glucose and insulin administration decreased fasting FFA levels (1) and Bierman, Dole and Roberts that patients with diabetes niellitus have high FFA levels (2). Experimental inteference with carbohydrate metabolism might also be expected to influence plasma FFA levels. The availability of 2-deoxy-D-glucose (2-DG) has made it possible to test this hypothesis. 2-DG is phosphorylated to 2-deoxyglucose-6-phosphate (2-DG-6-P), and it has been postulated that the 2-DG-6-P may compete for transport into the cell with glucose-6-phosphate (3). The purpose of this study was to observe the effect of 2-DG administration on FFA levels in normal human subjects and to study in addition the effect of glucose, insulin, fructose and lactate upon the pattern of response to 2-DG.

Ventricular arrhythmias induced in monkeys by the inhalation of aerosol propellants

After inhaling fluoroalkane gases, which are used as aerosol propellants, some people have died suddently and unexpectedly. Seeking an explanation, we had 14 monkeys inhale these gases. All developed ventricular premature beats, bigeminy, or tachycardia, which began at an average of 39 (SE +/-4.2) sec. Fluoroalkanes were present in blood, but arterial hypoxemia or hypercapnia was absent, and arterial pressure was reduced only slightly. In contrast, without fluoroalkanes, 3 min of asphyxia or anoxia caused arrhythmias in only one monkey whose arterial oxygen tension had fallen to 16 mm Hg. The ventricular arrhythmias caused in well oxygenated monkeys by fluoroalkane gases may either be mediated through beta adrenergic receptors, since propranolol abolished these arrhythmias, or result from a nonadrenergic, direct, toxic effect of these gases on the heart. These results suggest that some deaths after propellant inhalation may be caused by ventricular tachycardia or fibrillation.

The specific structure of compounds effecting fat mobilization in man.

Both epinephrine and norepinephrine enhance the process of fat mobilization. This property of promoting lipolysis has been observed both in vitro by demonstrating the release of free fatty acids (FFA) and glycerol from adipose tissue within the medium, and in vivo by the increase in the levels of plasma FFA in the fasted, resting individual (1-3). It was the intent of this study to determine whether the property of lipolysis was a singular characteristic of epinephrine and norepinephrine or whether other catechols and other vasoactive substances also could promote fat mobilization. It is known that a certain structureactivity relationship exists for the various sympathomimetic compounds as well as for other classes of drugs. It was of interest to determine whether lipolysis was also dependent upon a specific chemical structure.

Experimental stress and fat mobilization in lean and obese subjects

Abstract Analysis of free fatty acid values derived from 2 experimental stress situations involving volunteer young adult men reveals lower initial levels and diminished variability in obese subjects. In an exercise situation variability is significantly positively correlated with the initial level of FFA. These findings are discussed in relation to the possibility that insulin activity or adrenergic nervous system activity may be altered in obesity.